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Träfflista för sökning "L773:1476 5578 srt2:(2005-2009)"

Sökning: L773:1476 5578 > (2005-2009)

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  • Ng, M Y M, et al. (författare)
  • Meta-analysis of 32 genome-wide linkage studies of schizophrenia
  • 2009
  • Ingår i: Molecular Psychiatry. - 1359-4184 .- 1476-5578. ; 14:8, s. 774-785
  • Tidskriftsartikel (refereegranskat)abstract
    • A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for each bin across studies and determined the empirical probability of a given summed rank (P(SR)) by simulation. Suggestive evidence for linkage was observed in two single bins, on chromosomes 5q (142-168 Mb) and 2q (103-134 Mb). Genome-wide evidence for linkage was detected on chromosome 2q (119-152 Mb) when bin boundaries were shifted to the middle of the previous bins. The primary analysis met empirical criteria for 'aggregate' genome-wide significance, indicating that some or all of 10 bins are likely to contain loci linked to SCZ, including regions of chromosomes 1, 2q, 3q, 4q, 5q, 8p and 10q. In a secondary analysis of 22 studies of European-ancestry samples, suggestive evidence for linkage was observed on chromosome 8p (16-33 Mb). Although the newer genome-wide association methodology has greater power to detect weak associations to single common DNA sequence variants, linkage analysis can detect diverse genetic effects that segregate in families, including multiple rare variants within one locus or several weakly associated loci in the same region. Therefore, the regions supported by this meta-analysis deserve close attention in future studies.
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  • Reinius, Björn, et al. (författare)
  • Prenatal sex differences in the human brain
  • 2009
  • Ingår i: Molecular Psychiatry. - London, UK : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 14:11, s. 988-989
  • Tidskriftsartikel (refereegranskat)
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  • Sonestedt, Emily, et al. (författare)
  • Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort
  • 2008
  • Ingår i: European Journal of Clinical Nutrition. - : Nature Publishing Group. - 1476-5640. ; 62:8, s. 1005-1009
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods:Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results:The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 (95% CI, 0.22-0.72) for non-fasting samples.Conclusions:Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.European Journal of Clinical Nutrition advance online publication, 30 May 2007; doi:10.1038/sj.ejcn.1602811.
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