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Hypersensitivity to...
Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices
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Manousek, Jan (author)
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Andrsova, Irena (author)
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- Stejskal, Vera (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Masaryk Universit, Czech Republic
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Vlasinova, Jitka (author)
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Sepsi, Milan (author)
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Kuta, Jan (author)
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Klanova, Jana (author)
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Mazik, Michal (author)
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Jarkovsky, Jiri (author)
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Snajdrova, Lenka (author)
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Benesova, Klara (author)
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Novotny, Tomas (author)
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Zadakova, Andrea (author)
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Spinar, Jindrich (author)
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(creator_code:org_t)
- 2017-08-02
- 2018
- English.
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In: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 20:9, s. e140-e147
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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Abstract
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- AimsTo evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden.Methods and resultsThe cohort consisted of 20 men and 4 women (mean age: 62.3 +/- 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 +/- 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008).ConclusionOur findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Pacemaker
- Implantable cardioverter-defibrillator
- Late complication
- Metal pollutants
- Delayed-type hypersensitivity
- Lymphocyte transformation test
Publication and Content Type
- ref (subject category)
- art (subject category)
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Europace
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- By the author/editor
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Manousek, Jan
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Andrsova, Irena
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Stejskal, Vera
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Vlasinova, Jitka
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Sepsi, Milan
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Kuta, Jan
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show more...
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Klanova, Jana
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Mazik, Michal
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Jarkovsky, Jiri
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Snajdrova, Lenka
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Benesova, Klara
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Novotny, Tomas
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Zadakova, Andrea
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Spinar, Jindrich
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Europace
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Stockholm University