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Sökning: L773:1533 4406 > Karolinska Institutet

  • Resultat 1-10 av 323
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1.
  • Adami, HO, et al. (författare)
  • Cervical cancer and the elusive male factor
  • 2002
  • Ingår i: The New England journal of medicine. - 1533-4406. ; 346:15, s. 1160-1161
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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2.
  • Adami, HO, et al. (författare)
  • Management of early prostate cancer
  • 2014
  • Ingår i: The New England journal of medicine. - 1533-4406. ; 370:22, s. 2151-2151
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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3.
  • Adami, HO, et al. (författare)
  • Obesity and mortality from cancer
  • 2003
  • Ingår i: The New England journal of medicine. - 1533-4406. ; 348:17, s. 1623-1624
  • Tidskriftsartikel (refereegranskat)
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4.
  • Afshin, Ashkan, et al. (författare)
  • Health Effects of Overweight and Obesity in 195 Countries over 25 Years
  • 2017
  • Ingår i: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 377:1, s. 13-27
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND Although the rising pandemic of obesity has received major attention in many countries, the effects of this attention on trends and the disease burden of obesity remain uncertain. METHODS We analyzed data from 68.5 million persons to assess the trends in the prevalence of overweight and obesity among children and adults between 1980 and 2015. Using the Global Burden of Disease study data and methods, we also quantified the burden of disease related to high body-mass index (BMI), according to age, sex, cause, and BMI in 195 countries between 1990 and 2015. RESULTS In 2015, a total of 107.7 million children and 603.7 million adults were obese. Since 1980, the prevalence of obesity has doubled in more than 70 countries and has continuously increased in most other countries. Although the prevalence of obesity among children has been lower than that among adults, the rate of increase in childhood obesity in many countries has been greater than the rate of increase in adult obesity. High BMI accounted for 4.0 million deaths globally, nearly 40% of which occurred in persons who were not obese. More than two thirds of deaths related to high BMI were due to cardiovascular disease. The disease burden related to high BMI has increased since 1990; however, the rate of this increase has been attenuated owing to decreases in underlying rates of death from cardiovascular disease. CONCLUSIONS The rapid increase in the prevalence and disease burden of elevated BMI highlights the need for continued focus on surveillance of BMI and identification, implementation, and evaluation of evidence-based interventions to address this problem. 
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6.
  • Allander, T, et al. (författare)
  • A new arenavirus in transplantation
  • 2008
  • Ingår i: The New England journal of medicine. - 1533-4406. ; 358:24, s. 2638-2638
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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8.
  • Andersson, RE, et al. (författare)
  • Appendectomy and protection against ulcerative colitis
  • 2001
  • Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 344:11, s. 808-814
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: A history of appendectomy is rare in patients with ulcerative colitis. This suggests a protective effect of appendectomy or that appendicitis and ulcerative colitis are alternative inflammatory responses. We sought to characterize this inverse relation further. Methods:We studied a cohort of 212,963 patients who underwent appendectomy before the age of 50 years between 1964 and 1993 and a cohort of matched controls who were identified from the Swedish Inpatient Register and the nationwide census. The cohort was followed until 1995 for any subsequent diagnosis of ulcerative colitis. Results: Patients who underwent appendectomy for appendicitis and mesenteric lymphadenitis had a low risk of ulcerative colitis (for patients with perforated appendicitis, the adjusted hazard ratio was 0.58 [95 percent confidence interval, 0.38 to 0.87], for those with nonperforated appendicitis it was 0.76 [95 percent confidence interval, 0.65 to 0.90], and for those with mesenteric lymphadenitis it was 0.57 [95 percent confidence interval, 0.36 to 0.89]). In contrast, patients who underwent appendectomy for nonspecific abdominal pain had the same risk of ulcerative colitis as the controls (adjusted hazard ratio, 1.06, 95 percent confidence interval, 0.74 to 1.52). For the patients who had appendicitis, an inverse relation with the risk of ulcerative colitis was found only for those who underwent surgery before the age of 20 years (P<0.001). Conclusions: Appendectomy for an inflammatory condition (appendicitis or lymphadenitis) but not for nonspecific abdominal pain is associated with a low risk of subsequent ulcerative colitis. This inverse relation is limited to patients who undergo surgery before the age of 20 years.
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9.
  • Andriole, Gerald L, et al. (författare)
  • Effect of dutasteride on the risk of prostate cancer.
  • 2010
  • Ingår i: The New England journal of medicine. - 1533-4406. ; 362:13, s. 1192-202
  • Tidskriftsartikel (refereegranskat)abstract
    • We conducted a study to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on biopsy, among men who are at increased risk for the disease.
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