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A single dose of ve...
A single dose of vero cell-derived Japanese encephalitis (JE) vaccine (Ixiaro) effectively boosts immunity in travelers primed with mouse brain-derived JE vaccines
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Erra, Elina O (author)
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- Askling, Helena Hervius (author)
- Karolinska Institutet
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- Rombo, Lars (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
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Riutta, Jukka (author)
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Vene, Sirkka (author)
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Yoksan, Sutee (author)
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- Lindquist, Lars (author)
- Karolinska Institutet
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Pakkanen, Sari H (author)
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Huhtamo, Eili (author)
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Vapalahti, Olli (author)
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- Kantele, Anu (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2012-06-13
- 2012
- English.
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In: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1058-4838 .- 1537-6591. ; 55:6, s. 825-834
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND:A significant part of the world population lives in areas with endemic Japanese encephalitis (JE). For travelers from nonendemic countries, Vero cell-derived vaccine (JE-VC; Ixiaro) has replaced traditional mouse brain-derived vaccines (JE-MB) associated with safety concerns. The 2 vaccines are derived from different viral strains: JE-VC from the SA14-14-2 strain and JE-MB from the Nakayama strain. No data exist regarding whether JE-VC can be used to boost immunity after a primary series of JE-MB; therefore, a primary series of JE-VC has been recommended to all travelers regardless of previous vaccination history.METHODS:One hundred twenty travelers were divided into 4 groups: Volunteers with no prior JE vaccination received primary immunization with (group 1) JE-MB or (group 2) JE-VC, and those primed with JE-MB received a single booster dose of (group 3) JE-MB or (group 4) JE-VC. Immune responses were tested before and 4-8 weeks after vaccination using plaque reduction neutralization test (PRNT) against both vaccine strains.RESULTS:In vaccine-naive travelers, the vaccination response rate for test strains Nakayama and SA14-14-2 was 100% and 87% after primary vaccination with JE-MB and 87% and 94% after JE-VC, respectively. Antibody levels depended on the target virus, with higher titers against homologous than heterologous PRNT(50) target strain (P < .001). In travelers primed with JE-MB, vaccination response rates were 91% and 91%, and 98% and 95% after a booster dose of JE-MB or JE-VC, respectively. Subgroup analysis revealed that a higher proportion of primed (98%/95%) than nonprimed (39%/42%) volunteers responded to a single dose of JE-VC (P < .001).CONCLUSIONS:A single dose of JE-VC effectively boosted immunity in JE-MB-primed travelers. Current recommendations should be reevaluated.CLINICAL TRIALS REGISTRATION:NCT01386827.
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- By the author/editor
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Erra, Elina O
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Askling, Helena ...
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Rombo, Lars
-
Riutta, Jukka
-
Vene, Sirkka
-
Yoksan, Sutee
-
show more...
-
Lindquist, Lars
-
Pakkanen, Sari H
-
Huhtamo, Eili
-
Vapalahti, Olli
-
Kantele, Anu
-
show less...
- Articles in the publication
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Clinical Infecti ...
- By the university
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Uppsala University
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Karolinska Institutet