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Cerebrospinal Fluid...
Cerebrospinal Fluid Viral Load Across the Spectrum of Untreated Human Immunodeficiency Virus Type 1 (HIV-1) Infection: A Cross-Sectional Multicenter Study
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- Ulfhammer, Gustaf (författare)
- Göteborgs universitet,University of Gothenburg
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- Eden, Arvid (författare)
- Göteborgs universitet,University of Gothenburg
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- Antinori, Andrea (författare)
- National Institute of Infectious Diseases Lazzaro Spallanzani
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- Brew, Bruce J. (författare)
- University of Notre Dame,University of New South Wales (UNSW)
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- Calcagno, Andrea (författare)
- Universita degli Studi di Torino,University of Turin
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- Cinque, Paola (författare)
- IRCCS San Raffaele Scientific Institute
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- De Zan, Valentina (författare)
- IRCCS San Raffaele Scientific Institute
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- Hagberg, Lars (författare)
- Göteborgs universitet,University of Gothenburg
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- Lin, Amy (författare)
- Stanford University
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- Nilsson, Staffan, 1956 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Oprea, Cristiana (författare)
- Carol Davila University of Medicine and Pharmacy
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- Pinnetti, Carmela (författare)
- National Institute of Infectious Diseases Lazzaro Spallanzani
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- Spudich, Serena (författare)
- Yale University
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- Winston, Alan (författare)
- Imperial College of Science, Technology and Medicine
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Price, Richard W. (författare)
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- Gisslen, Magnus (författare)
- Göteborgs universitet,University of Gothenburg
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(creator_code:org_t)
- 2021-11-08
- 2022
- Engelska.
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Ingår i: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1058-4838 .- 1537-6591. ; 75:3, s. 493-502
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https://academic.oup...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background The aim of this large multicenter study was to determine variations in cerebrospinal fluid (CSF) HIV-RNA in different phases of untreated human immunodeficiency virus type 1 (HIV-1) infection and its associations with plasma HIV-RNA and other biomarkers. Methods Treatment naive adults with available CSF HIV-RNA quantification were included and divided into groups representing significant disease phases. Plasma HIV-RNA, CSF white blood cell count (WBC), neopterin, and albumin ratio were included when available. Results In total, 1018 patients were included. CSF HIV-RNA was in median (interquartile range [IQR]) 1.03 log(10) (0.37-1.86) copies/mL lower than in plasma, and correlated with plasma HIV-RNA (r = 0.44, P < .01), neopterin concentration in CSF (r = 0.49, P < .01) and in serum (r = 0.29, P < .01), CSF WBC (r = 0.34, P < .01) and albumin ratio (r = 0.25, P < .01). CSF HIV-RNA paralleled plasma HIV-RNA in all groups except neuroasymptomatic patients with advanced immunodeficiency (CD4 < 200) and patients with HIV-associated dementia (HAD) or opportunistic central nervous system (CNS) infections. Patients with HAD had the highest CSF HIV-RNA (in median [IQR] 4.73 (3.84-5.35) log(10) copies/mL). CSF > plasma discordance was found in 126 of 972 individuals (13%) and varied between groups, from 1% in primary HIV, 11% in neuroasymptomatic groups, up to 30% of patients with HAD. Conclusions Our study confirms previous smaller observations of variations in CSF HIV-RNA in different stages of HIV disease. Overall, CSF HIV-RNA was approximately 1 log(10) copies/mL lower in CSF than in plasma, but CSF discordance was found in a substantial minority of subjects, most commonly in patients with HAD, indicating increasing CNS compartmentalization paralleling disease progression. HIV-RNA is detectable in cerebrospinal fluid (CSF) across all stages of untreated HIV and usually parallel plasma HIV-RNA at a lower level. A substantial proportion (13%) of patients have CSF>plasma HIV-RNA, most commonly in patients with HIV-associated dementia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- HIV-RNA
- cerebrospinal fluid
- HIV-1
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Ulfhammer, Gusta ...
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Eden, Arvid
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Antinori, Andrea
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Brew, Bruce J.
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Calcagno, Andrea
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Cinque, Paola
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visa fler...
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De Zan, Valentin ...
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Hagberg, Lars
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Lin, Amy
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Nilsson, Staffan ...
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Oprea, Cristiana
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Pinnetti, Carmel ...
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Spudich, Serena
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Winston, Alan
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Price, Richard W ...
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Gisslen, Magnus
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