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Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents

Pierotti, Felipe Faria (author)
Univ Fed Sao Paulo, Sao Paulo, SP, Brazil.
Aranda, Carolina Sanchez (author)
Univ Fed Sao Paulo, Sao Paulo, SP, Brazil.
Cocco, Renata Rodrigues (author)
Univ Fed Sao Paulo, Sao Paulo, SP, Brazil.
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Sarinho, Emanuel (author)
Univ Fed Pernambuco, Recife, PE, Brazil.
Sano, Flavio (author)
Nipo Brasileiro Hosp, Sao Paulo, SP, Brazil.
Porto, Arnaldo (author)
Univ Passo Fundo, Passo Fundo, RS, Brazil.
Rosario, Nelson (author)
Univ Fed Parana, Curitiba, Parana, Brazil.
Chong Neto, Herberto Jose (author)
Univ Fed Parana, Curitiba, Parana, Brazil.
Goudouris, Ekaterini (author)
Univ Fed Rio de Janeiro, Rio De Janeiro, RJ, Brazil.
Moraes, Lilian Sanches (author)
Univ Fed Mato Grosso, Cuiaba, Mato Grosso, Brazil.
Wandalsen, Neusa Falbo (author)
Med Univ Santo Andre, Sao Paulo, SP, Brazil.
Mallozi, Marcia Carvalho (author)
Med Univ Santo Andre, Sao Paulo, SP, Brazil.
Pastorino, Antonio Carlos (author)
Univ Sao Paulo, Sao Paulo, SP, Brazil.
Franco, Jackeline Motta (author)
Univ Fed Sergipe, Sao Cristovao, Sergipe, Brazil.
Chavarria, Maria Leticia (author)
Univ Fed Goias, Goiania, Go, Brazil.
Borres, Magnus P, 1956- (author)
Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fisher Sci, Uppsala, Sweden
Sole, Dirceu (author)
Univ Fed Sao Paulo, Sao Paulo, SP, Brazil.
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Univ Fed Sao Paulo, Sao Paulo, SP, Brazil Univ Fed Pernambuco, Recife, PE, Brazil. (creator_code:org_t)
ELSEVIER ESPANA SLU, 2020
2020
English.
In: Allergologia et Immunopathologia. - : ELSEVIER ESPANA SLU. - 0301-0546 .- 1578-1267. ; 48:3, s. 259-264
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The clinical history is of importance in the investigation of allergic diseases but does have limitations. Many allergic conditions will be over-diagnosed if anamnesis alone is used for diagnostic criteria. Serum total immunoglobulin E (TIgE) quantification, as well as panels containing allergens prevalent in the studied population, may serve as screening tests and facilitate the diagnosis of allergic disease or its exclusion. We assessed the positivity of two versions of these tests, Phadiatop Europe (R) (PhEU) and Phadiatop Infant (R) (PhInf), as well as total IgE (TigE) values in patients with a medical diagnosis of allergic disease and non-allergic individuals. Methods: A cross-sectional study performed in eleven Brazilian pediatric allergy centers with patients divided into groups according to the primary condition and a group of assessed control subjects. They were submitted to TIgE measurement and screening tests (PhEu and PhInf). Results: TIgE mean serum levels were significantly higher among allergic patients, especially those with asthma/rhinitis or atopic dermatitis. The positivity of the screening tests, considering the total population, was 63.8% for PhEU and 72.6% for PhInf. These increased when we evaluated only the allergic subjects. The concordance index of the two tests was Kappa=0.7 and higher among those of greater age. Conclusions: In the assessed population, there were significantly higher levels among those with positive screening tests and PhInf showed better performance in the identification of sensitized individuals, regardless of age. This is the first study to evaluate Phadiatop and Phadiatop Infant in the same population. (C) 2019 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

Child
Hypersensitivity
Immunoglobulin E
Allergens
Screening tests

Publication and Content Type

ref (subject category)
art (subject category)

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