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> Grip Lars 1952 >
Risk prediction in ...
Risk prediction in acute coronary syndrome from serial in-hospital measurements of N-terminal pro-B-type natriuretic peptide.
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Nørgaard, Bjarne L (författare)
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Terkelsen, Christian J (författare)
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Riiskjaer, Mads (författare)
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Holmvang, Lene (författare)
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- Grip, Lars, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Heickendorff, Lene (författare)
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Thygesen, Kristian (författare)
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(creator_code:org_t)
- 2009-07-10
- 2008
- Engelska.
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Ingår i: Acute cardiac care. - : Informa UK Limited. - 1748-2941 .- 1748-295X. ; 10:3, s. 159-66
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- There is limited information about the in-hospital plasma profile of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with non-ST-elevation acute coronary syndrome (NSTACS) and furthermore, the prognostic influence of the timing of NT-proBNP measurements in NSTACS is unsettled. These subject matters are elucidated in this study composed of 455 patients with NSTACS (symptoms <24 h). NT-proBNP was measured at 0, 6, 12, 24, 36, 48, 72 and 96 h following admission. Any death was registered at follow-up (median: 2.3 years). The study demonstrated a monophasic profile of the plasma NT-proBNP values, reaching a maximum at 6 hours, and it showed an independent prognostic significance of NT-proBNP irrespective of the sampling time. Risk prediction by NT-proBNP was improved by combining the baseline measurement and one value taken between 24 and 96 h (at 48 h, P<0.001). No additional prognostic information was provided by including more than one late in-hospital NT-proBNP value. Conclusions: The in-hospital NT-proBNP measurements exhibit a monophasic profile in patients with NSTACS and these values provide independent prognostic information as regards mortality irrespective of the sampling time. Moreover, risk prediction of NT-proBNP is strengthened by combining the admission measurement with an additional value during the hospitalization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Acute Coronary Syndrome
- blood
- epidemiology
- Aged
- Electrocardiography
- Female
- Hospitalization
- Humans
- Male
- Middle Aged
- Natriuretic Peptide
- Brain
- blood
- Peptide Fragments
- blood
- Risk Assessment
- Troponin T
- blood
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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