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MTHFR polymorphisms...
MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males
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- Nilsson, Torbjörn K. (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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- Böttiger, Anna K., 1977- (författare)
- Region Örebro län,Department of Laboratory Medicine, Clinical Chemistry, Örebro University Hospital, Örebro, Sweden
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- Henriquez, Patricia (författare)
- Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas, Las Palmas de Gran Canaria, Spain
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- Serra Majem, Lluis (författare)
- Nutrition Research Group, Research Institute of Biomedical and Health Sciences, University of Las Palmas, Las Palmas de Gran Canaria, Spain
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(creator_code:org_t)
- 2014-08-28
- 2014
- Engelska.
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Ingår i: Molecular Medicine Reports. - : Spandidos Publications. - 1791-2997 .- 1791-3004. ; 10:5, s. 2706-2712
- Relaterad länk:
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- A total of 523 subjects (297 females and 226 males) from the Canary Islands Nutrition Study (ENCA) were studied in order to examine the effect of the MTHFR 677C>T, 1298A>C and 1793G>A polymorphisms, adjusted for age, serum (5)-folate and S-cobalamin levels, on total plasma homocysteine concentrations (tHcy). Genotyping was performed with Pyrosequencing(R) technology. The MTHFR 677T-allele was associated with increased tHcy concentrations only in males (P=0.005). The MTHFR 1298C-allele was found to be associated with higher tHcy levels but similarly, only in males (P=0.025). The MTHFR 1793A-allele was associated with decreased tHcy concentrations in the younger males (P=0.042). A haplotype-based approach was marginally superior in explaining the genetic interaction of the MTHFR polymorphisms on tHcy plasma levels (R-2 0.352 vs. 0.342 for a simple genotype-based approach). A nutrigenetic interaction between the MTHFR 677C>T genotype and S-cobalamin on tHcy levels was demonstrated in both genders. The increase in tHcy was more pronounced with decreasing S-cobalamin quintiles in 677TT homozygotes (P=0.005 for males and P=0.015 for females) than with decreasing S-folate quintiles (P for trend not significant). It was concluded that gene-nutrient interactions may differ depending on the sex and age of the subjects. The transferability of gene-nutrient interactions from one community to others may therefore be limited not only by different food patterns but also by different ages, genders and genotype distributions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
Nyckelord
- MTHFR genotypes
- haplotypes
- total homocysteine
- folate
- cobalamin
- nutrigenetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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