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Molecular inhibitio...
Molecular inhibition mechanisms of cell migration and invasion by coix polysaccharides in A549 NSCLC cells via targeting S100A4
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- Luo, Cheng (författare)
- Zhejiang Ocean Univ, Sch Food & Pharm, 1 Ocean Univ S Rd, Zhoushan 316022, Zhejiang, Peoples R China.
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- Wang, Xin (författare)
- Zhejiang Ocean Univ, Sch Food & Pharm, 1 Ocean Univ S Rd, Zhoushan 316022, Zhejiang, Peoples R China.
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- An, Can (författare)
- Zhejiang Ocean Univ, Sch Food & Pharm, 1 Ocean Univ S Rd, Zhoushan 316022, Zhejiang, Peoples R China.
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- Hwang, Chin-Fa (författare)
- Hung Kuang Univ, Dept Food Sci & Technol, Taichung 43302, Taiwan.
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- Miao, Wenhua (författare)
- Zhejiang Ocean Univ, Sch Food & Pharm, 1 Ocean Univ S Rd, Zhoushan 316022, Zhejiang, Peoples R China.
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- Yang, Lu (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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- Xu, Maonian (författare)
- Univ Helsinki, Div Food Chem, Dept Food & Environm Sci, F-00014 Helsinki, Finland.
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- Bai, Aiping (författare)
- Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.
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- Deng, Shanggui (författare)
- Zhejiang Ocean Univ, Sch Food & Pharm, 1 Ocean Univ S Rd, Zhoushan 316022, Zhejiang, Peoples R China.
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Zhejiang Ocean Univ, Sch Food & Pharm, 1 Ocean Univ S Rd, Zhoushan 316022, Zhejiang, Peoples R China Hung Kuang Univ, Dept Food Sci & Technol, Taichung 43302, Taiwan. (creator_code:org_t)
- 2016-12-05
- 2017
- Engelska.
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Ingår i: Molecular Medicine Reports. - : Spandidos Publications. - 1791-2997 .- 1791-3004. ; 15:1, s. 309-316
- Relaterad länk:
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- S100 calcium binding protein A4 (S100A4) promotes extracellular signal transduction, intercellular adhesion, motility and mobility. Different extracts from Coix lachryma-jobi have been used for the treatment of various types of cancer in Asia. In our previous study, the polysaccharide fraction extact, CP1, induced cell apoptosis of non-small cell lung cancer cells. In the current study, CP1 inhibited migration and invasion of A549 cells in a scratch wound healing assay and matrigel invasion assay, respectively. Furthermore, reverse transcription-polymerase chain reaction and western blotting demonstrated that CP1 downregulated the gene and protein expression levels of SI00A4. In silico docking analysis demonstrated that polysaccharides may not interfere with dimerization, whereas, the affinity of polysaccharides for an S100A4-NMIIA pocket was margnially greater than at the dimerization sites. Thus, CP1 inhibited A549 cell migration and invasion potentially via downregulation of S100A4, and may also interact with the binding site of S100A4-NMIIA, which indicated that CP1 has potential as an alternative cancer chemotherapeutic by targeting S100A4.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- S100A4 dimerization/S100A4-NMIIA complex
- A549 NSCLC cells
- polysaccharide CP1
- migration/invasion
- scratch wound healing assay
- Matrigel assay
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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