| 1. |
- Aune, Emma, 1991, et al.
(författare)
-
Clinical characteristics and survival in patients with heart failure experiencing in hospital cardiac arrest
- 2022
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- In patients with heart failure (HF) who suffered in-hospital cardiac arrest (IHCA), little is known about the characteristics, survival and neurological outcome. We used the Swedish Registry of Cardiopulmonary Resuscitation to study this, including patients aged >= 18 years suffering IHCA (2008-2019), categorised as HF alone, HF with acute myocardial infarction (AMI), AMI alone, or other. Odds ratios (OR) for 30-day survival, trends in 30-day survival, and the implication of HF phenotype was studied. 6378 patients had HF alone, 2111 had HF with AMI, 4210 had AMI alone. Crude 5-year survival was 9.6% for HF alone, 12.9% for HF with AMI and 34.6% for AMI alone. The 5-year survival was 7.9% for patients with HF and left ventricular ejection fraction (LVEF) >= 50%, 15.4% for LVEF < 40% and 12.3% for LVEF 40-49%. Compared with AMI alone, adjusted OR (95% CI) for 30-day survival was 0.66 (0.60-0.74) for HF alone, and 0.49 (0.43-0.57) for HF with AMI. OR for 30-day survival in 2017-2019 compared with 2008-2010 were 1.55 (1.24-1.93) for AMI alone, 1.37 (1.00-1.87) for HF with AMI and 1.30 (1.07-1.58) for HF alone. Survivors with HF had good neurological outcome in 92% of cases.
|
|
| 2. |
|
|
| 3. |
- Biswas, Tuser, 1988-, et al.
(författare)
-
Effects of ink characteristics and piezo-electric inkjetting parameters on lysozyme activity
- 2019
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:18252
-
Tidskriftsartikel (refereegranskat)abstract
- Inkjet printing of enzymes can facilitate many novel applications where a small amount of materials need to be deposited in a precise and flexible manner. However, maintaining the satisfactory activity of inkjet printed enzyme is a challenging task due to the requirements of ink rheology and printhead parameters. Thus to find optimum inkjetting conditions we studied the effects of several ink formulation and jetting parameters on lysozyme activity using a piezoelectric printhead. Within linear activity range of protein concentrations ink containing 50 µg/mL lysozyme showed a satisfactory activity retention of 85%. An acceptable activity of jetted ink was found at pH 6.2 and ionic strength of 0.06 molar. Glycerol was found to be an effective viscosity modifier (10–15 mPa.s), humectant and protein structure stabilizer for the prepared ink. A non-ionic surfactant when used just below critical micelle concentration was found to be favourable for the jetted inks. An increase in activity retention was observed for inks jetted after 24 hours of room temperature incubation. However, no additional activity was seen for inkjetting above the room temperature. Findings of this study would be useful for formulating other protein-based inks and setting their inkjet printing parameters without highly compromising the functionality.
|
|
| 4. |
- Biswas, Tuser, 1988-, et al.
(författare)
-
Piezoelectric inkjet printing of tyrosinase (polyphenol oxidase) enzyme on atmospheric plasma treated polyamide fabric
- 2022
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Tyrosinase enzyme was digitally printed on plasma pretreated polyamide-6,6 fabric using several sustainable technologies. Ink containing carboxymethyl cellulose was found to be the most suitable viscosity modifier for this enzyme. Before and after being deposited on the fabric surface, the printed inks retained enzyme activity of 69% and 60%, respectively, compared to activity prior printing process. A good number of the printed enzyme was found to be strongly adsorbed on the fabric surface even after several rinsing cycles due to surface activation by plasma treatment. Rinsed out fabrics retained a maximum activity of 34% resulting from the well-adsorbed enzymes. The activity of tyrosinase on printed fabrics was more stable than ink solution for at least 60 days. Effects of pH, temperature and enzyme kinetics on ink solution and printed fabrics were assessed. Tyrosinase printed synthetic fabrics can be utilized for a range of applications from biosensing and wastewater treatment to cultural heritage works.
|
|
| 5. |
- Blom, Eva-Lotta, 1973, et al.
(författare)
-
Continuous but not intermittent noise has a negative impact on mating success in a marine fish with paternal care
- 2019
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Anthropogenic underwater noise is a global pollutant of increasing concern but its impact on reproduction in fish is largely unknown. Hence, a better understanding of its consequences for this important link to fitness is crucial. Working in aquaria, we experimentally tested the impact of broadband noise exposure (added either continuously or intermittently), compared to a control, on the behaviour and reproductive success of the common goby (Pomatoschistus microps), a vocal fish with exclusive paternal care. Compared to the intermittent noise and control treatments, the continuous noise treatment increased latency to female nest inspection and spawning and decreased spawning probability. In contrast, many other female and male pre-spawning behaviours, and female ventilation rate (proxies for stress levels) did not differ among treatments. Therefore, it is likely that female spawning decisions were delayed by a reduced ability to assess male acoustic signals, rather than due to stress per se and that the silent periods in the intermittent noise treatment provided a respite where the females could assess the males. Taken together, we show that noise (of similar frequency range as anthropogenic boat noise) negatively affects reproductive success, particularly under a continuous noise exposure.
|
|
| 6. |
- Dejby, Ellen, et al.
(författare)
-
Left-sided valvular heart disease and survival in out-of-hospital cardiac arrest: a nationwide registry-based study.
- 2023
-
Ingår i: Scientific reports. - 2045-2322. ; 13:1
-
Tidskriftsartikel (refereegranskat)abstract
- Survival in left-sided valvular heart disease (VHD; aortic stenosis [AS], aortic regurgitation [AR], mitral stenosis [MS], mitral regurgitation [MR]) in out-of-hospital cardiac arrest (OHCA) is unknown. We studied all cases of OHCA in the Swedish Registry for Cardiopulmonary Resuscitation. All degrees of VHD, diagnosed prior to OHCA, were included. Association between VHD and survival was studied using logistic regression, gradient boosting and Cox regression. We studied time to cardiac arrest, comorbidities, survival, and cerebral performance category (CPC) score. We included 55,615 patients; 1948 with AS (3,5%), 384 AR (0,7%), 17 MS (0,03%), and 704 with MR (1,3%). Patients with MS were not described due to low case number. Time from VHD diagnosis to cardiac arrest was 3.7 years in AS, 4.5 years in AR and 4.1 years in MR. ROSC occurred in 28% with AS, 33% with AR, 36% with MR and 35% without VHD. Survival at 30 days was 5.2%, 10.4%, 9.2%, 11.4% in AS, AR, MR and without VHD, respectively. There were no survivors in people with AS presenting with asystole or PEA. CPC scores did not differ in those with VHD compared with no VHD. Odds ratio (OR) for MR and AR showed no difference in survival, while AS displayed OR 0.58 (95% CI 0.46-0.72), vs no VHD. AS is associated with halved survival in OHCA, while AR and MR do not affect survival. Survivors with AS have neurological outcomes comparable to patients without VHD.
|
|
| 7. |
- Diaz Cruz, Maria Araceli, et al.
(författare)
-
Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden
- 2022
-
Ingår i: Scientific Reports. - : Nature Portfolio. - 2045-2322. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Numerous studies have shown that lifestyle factors, such as regular physical activity and vitamin D intake, may remarkably improve overall health and mental wellbeing. This is especially important in older adults whose vitamin D deficiency occurs with a high prevalence. This study aimed to examine the influence of lifestyle and vitamin D on global DNA methylation patterns in an elderly cohort in Southwest of Sweden. We also sought to examine the methylation levels of specific genes involved in vitamin D's molecular and metabolic activated pathways. We performed a genome wide methylation analysis, using Illumina Infinium DNA Methylation EPIC 850kBeadChip array, on 277 healthy individuals from Southwest Sweden at the age of 70-95. The study participants also answered queries on lifestyle, vitamin intake, heart medication, and estimated health. Vitamin D intake did not in general affect methylation patterns, which is in concert with other studies. However, when comparing the group of individuals taking vitamin supplements, including vitamin D, with those not taking supplements, a difference in methylation in the solute carrier family 25 (SCL25A24) gene was found. This confirms a previous finding, where changes in expression of SLC25A24 were associated with vitamin D treatment in human monocytes. The combination of vitamin D intake and high physical activity increased methylation of genes linked to regulation of vitamin D receptor pathway, the Wnt pathway and general cancer processes. To our knowledge, this is the first study detecting epigenetic markers associated with the combined effects of vitamin D supplementation and high physical activity. These results deserve to be further investigated in an extended, interventional study cohort, where also the levels of 25(OH)D3 can be monitored.
|
|
| 8. |
- Eutionnat-Diffo, Prisca, 1992-, et al.
(författare)
-
Stress, strain and deformation of poly-lactic acid filament deposited onto polyethylene terephthalate woven fabric through 3D printing process
- 2019
-
Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
-
Tidskriftsartikel (refereegranskat)abstract
- Although direct deposition of polymeric materials onto textiles through 3D printing is a great technique used more and more to develop smart textiles, one of the main challenges is to demonstrate equal or better mechanical resistance, durability and comfort than those of the textile substrates before deposition process. This article focuses on studying the impact of the textile properties and printing platform temperature on the tensile and deformations of non-conductive and conductive poly lactic acid (PLA) filaments deposited onto polyethylene terephthalate (PET) textiles through 3D printing process and optimizing them using theoretical and statistical models. The results demonstrate that the deposition process affects the tensile properties of the printed textile in comparison with the ones of the textiles. The stress and strain at rupture of the first 3D printed PLA layer deposited onto PET textile material reveal to be a combination of those of the printed layer and the PET fabric due to the lower flexibility and diffusion of the polymeric printed track through the textile fabric leading to a weak adhesion at the polymer/textile interface. Besides, printing platform temperature and textile properties influence the tensile and deformation properties of the 3D printed PLA on PET textile significantly. Both, the washing process and the incorporation of conductive fillers into the PLA do not affect the tensile properties of the extruded polymeric materials. The elastic, total and permanent deformations of the 3D-printed PLA on PET fabrics are lower than the ones of the fabric before polymer deposition which demonstrates a better dimensional stability, higher stiffness and lower flexibility of these materials.
|
|
| 9. |
- Gunnarsson, Emanuel, et al.
(författare)
-
Seamlessly integrated textile electrodes and conductive routing in a garment for electrostimulation: design, manufacturing and evaluation
- 2023
-
Ingår i: Scientific Reports. - 2045-2322. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- Electro-stimulation to alleviate spasticity, pain and to increase mobility has been used successfully for years. Usually, gelled electrodes are used for this. In a garment intended for repeated use such electrodes must be replaced. The Mollii-suit by the company Inerventions utilises dry conductive rubber electrodes. The electrodes work satisfactory, but the garment is cumbersome to fit on the body. In this paper we show that knitted dry electrodes can be used instead. The knitted electrodes present a lower friction against the skin and a garment is easily fitted to the body. The fabric is stretchable and provides a tight fit to the body ensuring electrical contact. We present three candidate textrodes and show how we choose the one with most favourable features for producing the garment. We validate the performance of the garment by measuring three electrical parameters: rise time (10–90%) of the applied voltage, net injected charge and the low frequency value of the skin–electrode impedance. It is concluded that the use of flat knitting intarsia technique can produce a garment with seamlessly integrated conductive leads and electrodes and that this garment delivers energy to the body as targeted and is beneficial from manufacturing and comfort perspectives.
|
|
| 10. |
- Iyer, Sweta, 1987-, et al.
(författare)
-
Study of photoluminescence property on cellulosic fabric using multifunctional biomaterials riboflavin and its derivative Flavin mononucleotide
- 2019
-
Ingår i: Scientific Reports. - London : Nature Publishing Group. - 2045-2322. ; :9
-
Tidskriftsartikel (refereegranskat)abstract
- Flavins are ubiquitous in nature and participate in various biochemical reactions mainly in the form of coenzyme Flavin mononucleotide (FMN) or as precursor such as Riboflavin (RF). Both flavins, RF and FMN are multifunctional bio-based molecules yielding yellow coloration and exhibit photoluminescence, UV protection, and redox properties. The aim of the present research study was to investigate the diffusion method as a technique to obtain photoluminescent cellulosic fabric using multifunctional RF and FMN. The photoluminescent moiety RF and FMN exhibited three maximum absorbance peaks at about 270 nm, 370 nm and 446 nm in aqueous solution at pH 7. The solutions of RF and FMN with concentration 4% and 20% (owf) at pH 7 were prepared and used in diffusion method for cellulosic fabric dyeing. The study involved the determination of color performance and evaluation of luminescence property of the dyed fabric using UV-visible spectrophotometer and photoluminescence spectroscopy, respectively. Under monochromatic UV lamp exposure emitting at 370 nm, the dyed fabric showed an intense emission of greenish yellow color, which was later confirmed by the intense photoluminescence observed at a wavelength of about 570 nm. The study demonstrates the theoretical evaluation of quantum efficiency (φ) obtaining maximum φ value of 0.28. Higher color strength value and improved wash fastness were obtained by treatment with different biobased mordants such as tannic acid and citric acid as well as calcium chloride for both RF and FMN. Additionally, ultraviolet (UV) protection ability for both RF and FMN dyed fabric were determined and showed UPF factor of 50+ and 35 respectively. The work allowed us to explore the photoluminescence property of riboflavin and Flavin mononucleotide for its application in the field of textiles as a new scope of producing photoluminescent textile along with multifunctional properties such as coloration and UV protection.
|
|
