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Träfflista för sökning "L773:0012 186X ;srt2:(2005-2009)"

Sökning: L773:0012 186X > (2005-2009)

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Numrering	Referens	Omslagsbild	Hitta
61.	Bryzgalova, G, et al. (författare) Estradiol treatment decreases body weight and improves insulin sensitivity in aged female mice fed on a high fat diet 2007 Ingår i: DIABETOLOGIA. - 0012-186X. ; 50, s. S280-S281 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
62.	Bryzgalova, G, et al. (författare) Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver 2006 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 49:3, s. 588-597 Tidskriftsartikel (refereegranskat)abstract Aims/hypothesis: We used oestrogen receptor-alpha (ER alpha) knockout (ERKO) and receptor-beta (ER beta) knockout (BERKO) mice to investigate the mechanism(s) behind the effects of oestrogens on glucose homeostasis. Methods: Endogenous glucose production (EGP) was measured in ERKO mice using a euglycaemic-hyperinsulinaemic clamp. Insulin secretion was determined from isolated islets. In isolated muscles, glucose uptake was assayed by using radiolabelled isotopes. Genome-wide expression profiles were analysed by high-density oligonucleotide microarray assay, and the expression of the genes encoding steroyl-CoA desaturase and the Leptin receptor (Scd1 and Lepr, respectively) was confirmed by RT-PCR. Results: ERKO mice had higher fasting blood glucose, plasma insulin levels and IGT. The plasma leptin level was increased, while the adiponectin concentration was decreased in ERKO mice. Levels of both glucose- and arginine-induced insulin secretion from isolated islets were similar in ERKO and wild-type mice. The euglycaemic-hyperinsulinaemic clamp revealed that suppression of EGP by increased insulin levels was blunted in ERKO mice, which suggests a pronounced hepatic insulin resistance. Microarray analysis revealed that in ERKO mice, the genes involved in hepatic lipid biosynthesis were upregulated, while genes involved in lipid transport were downregulated. Notably, hepatic Lepr expression was decreased in ERKO mice. In vitro studies showed a modest decrease in insulin-mediated glucose uptake in soleus and extensor digitorum longus (EDL) muscles of ERKO mice. BERKO mice demonstrated normal glucose tolerance and insulin release. Conclusions/interpretation: We conclude that oestrogens, acting via ER alpha, regulate glucose homeostasis mainly by modulating hepatic insulin sensitivity, which can be due to the upregulation of lipogenic genes via the suppression of Lepr expression.
63.	Buschard, K., et al. (författare) Involvement of sulfatide in beta cells and type 1 and type 2 diabetes 2005 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 48:10, s. 1957-62 Tidskriftsartikel (refereegranskat)abstract Mammalian tissues express beta-isoforms of glycosphingolipids and, among these, sulfatide (sulphated galactosylceramide) is present in the beta cells, and it is here that the short fatty acid chain (C16) isoform is predominately found. In vitro studies have shown that sulfatide preserves insulin crystals and facilitates insulin monomerisation under certain biochemical conditions. It also activates beta cell potassium channels and moderates insulin secretion. Anti-sulfatide antibodies are seen in type 1 diabetes, and immunological presentation of glycosphingolipids by the non-classical CD1 molecules has recently been reported. It is via this mechanism that alpha-galactosylceramide and sulfatide are able to influence the innate immune system and inhibit autoimmunity, possibly through regulatory natural killer T cells. Administration of sulfatide substantially reduces the incidence of diabetes in non-obese diabetic mice and prevents antigen-induced experimental autoimmune encephalomyelitis in wild-type mice. Sulfatide has specific anti-inflammatory properties, increasing the number of CD3+CD25+ regulatory T cells and reducing production of several cytokines, including TNF-alpha. Patients with type 2 diabetes have low serum concentrations of sulfatide, and some animal models of type 2 diabetes have low pancreatic expression of C16:0 sulfatide; administration of this increases insulin secretion and improves first-phase insulin response in Zucker fatty rats. Glycosphingolipids in general, and sulfatide in particular, appear relevant to both type 1 and type 2 diabetes.
64.	Carlsson, A, et al. (författare) Better Diabetes Diagnostic (BDD): A country-wide registry of incident patients suggests an altered HLA genotype distribution from 1986-87 2006 Ingår i: DIABETOLOGIA. - 0012-186X. ; 49, s. 175-175 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
65.	Carlsson, S, et al. (författare) Age, overweight and physical inactivity increase the risk of latent autoimmune diabetes in adults: results from the Nord-Trøndelag health study 2007 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 50:1, s. 55-58 Tidskriftsartikel (refereegranskat)
66.	Carlsson, S, et al. (författare) Alcohol consumption and type 2 diabetes Meta-analysis of epidemiological studies indicates a U-shaped relationship 2005 Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 48:6, s. 1051-1054 Tidskriftsartikel (refereegranskat)
67.	Carlsson, S, et al. (författare) Body mass index, physical inactivity and type 2 diabetes - are these associations explained by genetic selection? Results from the Swedish twin register 2009 Ingår i: DIABETOLOGIA. - 0012-186X. ; 52, s. S327-S327 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
68.	Carlsson, S, et al. (författare) Insulin resistance precipitates autoimmune diabetes in the adult (LADA) without affecting parameters of the immune process. Results from the Nord-Trondelag Study 2006 Ingår i: DIABETOLOGIA. - 0012-186X. ; 49, s. 181-182 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
69.	Catrina, SB, et al. (författare) Impaired reaction to hypoxia as a mechanism for development of diabetic foot ulcers 2007 Ingår i: DIABETOLOGIA. - 0012-186X. ; 50, s. S463-S463 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
70.	Catrina, SB, et al. (författare) Stabilisation of HIF-1 alpha is sufficient to reverse the negative effect of hyperglycaemia on HIF function and to markedly improve wound healing in diabetic mice 2008 Ingår i: DIABETOLOGIA. - 0012-186X. ; 51, s. S510-S510 Konferensbidrag (övrigt vetenskapligt/konstnärligt)

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