| 1. |
- Ankerst, Jaro, et al.
(författare)
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Effect of selenium on the induction of breast fibroadenomas by adenovirus type 9 and 1,2‐dimethylhydrazine‐induced bowel carcinogenesis in rats
- 1982
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 29:6, s. 707-710
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Tidskriftsartikel (refereegranskat)abstract
- Selenium in its organic and inorganic forms has been shown to inhibit the development of chemically induced, spontaneous and transplanted tumors. The present investigation was performed to study the effect of selenium (4 μg per ml of drinking water) on tumorigenesis of adenovirus‐type‐9‐induced breast fibroadenomas and on 1,2‐dimethylhydrazine‐induced bowel carcinogenesis in WF rats. It was found that identical treatment with Se under identical conditions and with no obvious toxic effects on the rats (I) resulted in inhibition of DMH‐induced large‐bowel carcinogenesis; (2) facilitated induction of small‐bowel cancer by the same carcinogen in the same animals, and (3) greatly facilitated induction of breast fibroadenoma by adenovirus type 9 in the same strain of rats. The effect of Se treatment on DMH‐induced largebowel carcinogenesis confirms previous findings and proves that the opposite effect on fibroadenoma development is not due to differences in e.g. effective dose, animal strains or condition of the animals. It is not yet clear through which mechanisms Se exerts these effects.
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| 2. |
- Fäldt, R., et al.
(författare)
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Possibly specific immune complexes in sera of patients with untreated acute myelogenous leukemia
- 1980
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 26:3, s. 309-314
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Tidskriftsartikel (refereegranskat)abstract
- Eleven patients with acute myelogenous leukemia (AML) in the acute stage of the disease were studied. Sera of seven patients were assayed for complement‐dependent cytotoxicity to autochthonous AML cells and sera of four patients were tested with allogeneic target cells before and after ultrafiltration at low pH. No specific cytotoxic activity could be detected in any untreated sera. Ultrafiltration at low pH led, however, to the appearance of a significant cytotoxic activity in all of seven autochthonous and in three of four allogeneic combinations. Identical treatment of control AB sera did not result in any similar activity. The results show that potentially cytotoxic antibodies to leukemia‐associated antigens are present in the acute stage of acute myelogenous leukemia. However, they do not express complement‐dependent cytotoxicity in untreated sera. After ultrafiltration at low pH significant complement‐dependent cytotoxicity was detectable in most of the sera. One possible explanation is that cytotoxic antibodies to leukemia‐associated antigens are present in the form of circulating immune complexes. Splitting of them at low pH and elimination of the antigen component might result in an increased amount of free cytotoxic antibodies.
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| 4. |
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| 5. |
- Ljungberg, Michael, et al.
(författare)
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Dose planning with SPECT
- 1988
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 41:S2, s. 67-70
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Tidskriftsartikel (refereegranskat)abstract
- In nuclear medicine imaging, single photon emission computed tomography (SPECT) is used with increasing frequency for studies of different organs. A new approach is to use quantitative SPECT for dose planning in radionuclide therapy. Important parameters to estimate dose planning are described here.
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