| 31. |
- Antonelli, Alexandre, 1978, et al.
(författare)
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The pitfalls of taking science to the public
- 2018
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 359
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 32. |
- Arner, E, et al.
(författare)
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Health and obesity: not just skin deep
- 2013
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 342:6158, s. 558-559
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 33. |
- Arner, P
(författare)
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Medicine. Lipases in cachexia
- 2011
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 333:6039, s. 163-164
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Tidskriftsartikel (refereegranskat)abstract
- Enzymes expressed in adipose tissue are involved in the loss of fat mass that occurs in a cancer-associated wasting disorder.
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| 34. |
- Arnqvist, Göran
(författare)
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Comment on "Bateman in Nature: Predation on Offspring Reduces the Potential for Sexual Selection"
- 2013
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 340:6132, s. 549-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Byers and Dunn (Reports, 9 November 2012, p. 802) reported that sexual selection and natural selection are closely related in a wild population of pronghorns. Here, I argue that this conclusion is incorrect. Their main finding is due to the fact that, unsurprisingly, juvenile mortality and juvenile survival are negatively related across years.
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| 35. |
- Arpaia, Riccardo, 1985, et al.
(författare)
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Dynamical charge density fluctuations pervading the phase diagram of a Cu-based high-Tc superconductor
- 2019
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 365:6456, s. 906-910
-
Tidskriftsartikel (refereegranskat)abstract
- Charge density modulations have been observed in all families of high–critical temperature (Tc) superconducting cuprates. Although they are consistently found in the underdoped region of the phase diagram and at relatively low temperatures, it is still unclear to what extent they influence the unusual properties of these systems. Using resonant x-ray scattering, we carefully determined the temperature dependence of charge density modulations in YBa2Cu3O7–d and Nd1+xBa2–xCu3O7–d for several doping levels. We isolated short-range dynamical charge density fluctuations in addition to the previously known quasi-critical charge density waves. They persist up to well above the pseudogap temperature T*, are characterized by energies of a few milli–electron volts, and pervade a large area of the phase diagram.
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| 36. |
- Asai, Masato, et al.
(författare)
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Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity
- 2013
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 341:6143, s. 275-278
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Tidskriftsartikel (refereegranskat)abstract
- Melanocortin receptor accessory proteins (MRAPs) modulate signaling of melanocortin receptors in vitro. To investigate the physiological role of brain-expressed melanocortin 2 receptor accessory protein 2 (MRAP2), we characterized mice with whole-body and brain-specific targeted deletion of Mrap2, both of which develop severe obesity at a young age. Mrap2 interacts directly with melanocortin 4 receptor (Mc4r), a protein previously implicated in mammalian obesity, and it enhances Mc4r-mediated generation of the second messenger cyclic adenosine monophosphate, suggesting that alterations in Mc4r signaling may be one mechanism underlying the association between Mrap2 disruption and obesity. In a study of humans with severe, early-onset obesity, we found four rare, potentially pathogenic genetic variants in MRAP2, suggesting that the gene may also contribute to body weight regulation in humans.
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| 37. |
- Balafoutas, L., et al.
(författare)
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Affirmative action policies promote women and do not harm efficiency in the lab
- 2012
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 335:6068, s. 579-582
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Tidskriftsartikel (refereegranskat)abstract
- Gender differences in choosing to enter competitions are one source of unequal labor market outcomes concerning wages and promotions. Given that studying the effects of policy interventions to support women is difficult with field data because of measurement problems and potential lack of control, we evaluated, in a set of controlled laboratory experiments, four interventions: quotas, where one of two winners of a competition must be female; two variants of preferential treatment, where a fixed increment is added to women’s performance; and repetition of the competition, where a second competition takes place if no woman is among the winners. Compared with no intervention, all interventions encourage women to enter competitions more often, and performance is at least equally good, both during and after the competition.
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| 38. |
- Balzarotti, Francisco, et al.
(författare)
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Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes
- 2017
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 355:6325, s. 606-612
-
Tidskriftsartikel (refereegranskat)abstract
- We introduce MINFLUX, a concept for localizing photon emitters in space. By probing the emitter with a local intensity minimum of excitation light, MINFLUX minimizes the fluorescence photons needed for high localization precision. In our experiments, 22 times fewer fluorescence photons are required as compared to popular centroid localization. In superresolutionmicroscopy, MINFLUXattained similar to 1-nanometer precision, resolving molecules only 6 nanometers apart. MINFLUX tracking of single fluorescent proteins increased the temporal resolution and the number of localizations per trace by a factor of 100, as demonstrated with diffusing 30S ribosomal subunits in living Escherichia coli. As conceptual limits have not been reached, we expect this localization modality to break new ground for observing the dynamics, distribution, and structure of macromolecules in living cells and beyond.
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| 39. |
- Barbier, Estelle, et al.
(författare)
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A molecular mechanism for choosing alcohol over an alternative reward
- 2018
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 360:6395
-
Tidskriftsartikel (refereegranskat)abstract
- Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which similar to 15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the g-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder.
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| 40. |
- Bargues Tobella, Aida, et al.
(författare)
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Forest restoration: Transformative trees
- 2019
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 366, s. 316-317
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Tidskriftsartikel (refereegranskat)
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