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Träfflista för sökning "L773:1013 7424 srt2:(1994)"

Sökning: L773:1013 7424 > (1994)

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1.
  • Elmstahl, S., et al. (författare)
  • Quantitative EEG in elderly patients with Alzheimer's disease and healthy controls
  • 1994
  • Ingår i: Dementia (Switzerland). - : S. Karger AG. - 1013-7424. ; 5:2, s. 119-124
  • Tidskriftsartikel (refereegranskat)abstract
    • Multichannel (19) EEG were analyzed in 23 female patients with rather advanced late-onset Alzheimer's disease (AD) and compared with 56 age- and sex-matched healthy control subjects. The quantified EEG was correlated with psychometric and clinical variables. The control subjects showed increasing theta activity with age but the EEG changes did not correlate significantly with psychometric features. The AD patients showed highly significant increases in delta and theta activity and decreases in beta activity compared with controls. The EEG changes were most marked over posterior regions of the brain. The individual EEG variables showed a high degree of intercorrelation and an almost complete discrimination between patients and controls was accomplished by taking only the posterior delta activity into account. In a subgroup of 10 patients, in which a Mini Mental test score could be obtained, the score correlated with the relative theta power.
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2.
  • Johansson, Barbro (författare)
  • Pathogenesis of vascular dementia: the possible role of hypertension
  • 1994
  • Ingår i: Dementia (Switzerland). - : S. Karger AG. - 1013-7424. ; 5:3-4, s. 174-176
  • Tidskriftsartikel (refereegranskat)abstract
    • In spite of the fact that hypertension is the main risk factor for cerebrovascular disease, retrospective studies have not given a clear answer concerning the role of hypertension in vascular dementia. Hypertension predisposes to intracerebral and extracerebral arterial alterations which may cause cerebrovascular events by a number of mechanisms. In addition to the established association between hypertension and stroke, the role of hypertension for silent white matter hyperintensities (WMHIs) observed on magnetic resonance imaging is debated. Data are presented indicating that WMHIs are rare below the age of 55 in normotensive individuals but are not infrequent when the blood pressure is moderately or markedly increased. It is proposed that the possible role of hypertension in vascular dementia should be evaluated in prospective studies of hypertensive populations.
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3.
  • Minthon, Lennart, et al. (författare)
  • Tacrine treatment modifies cerebrospinal fluid neuropeptide levels in Alzheimer's disease
  • 1994
  • Ingår i: Dementia (Switzerland). - : S. Karger AG. - 1013-7424. ; 5:6, s. 295-301
  • Tidskriftsartikel (refereegranskat)abstract
    • Biochemical and histochemical studies have demonstrated a widespread deficit in the activity of acetylcholinesterase (AChE) in the brains of patients with Alzheimer's disease (DAT). Multiple disturbances in several transmitter systems have been found. The most consistent neurochemical changes in DAT are reductions in the cholinergic system. The major pharmacological approach today in DAT is based on the cholinergic theory assuming that acetylcholine has a major cortical impact on cognitive processes. Tetrahydroaminoacridine (THA, tacrine) is a centrally active reversible acetylcholinesterase inhibitor. A large number of trials have been performed in patients with DAT. This article was to evaluate whether THA treatment induced neuropeptide alteration in DAT before and after 1 year on oral THA treatment.
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  • Resultat 1-3 av 3
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tidskriftsartikel (3)
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refereegranskat (3)
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Minthon, Lennart (1)
Edvinsson, Lars (1)
Gullberg, B (1)
Gustafson, Lars (1)
Johansson, Barbro (1)
Rosen, I. (1)
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Elmstahl, S. (1)
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Lunds universitet (3)
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Engelska (3)
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Medicin och hälsovetenskap (3)
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