SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1097 6825 srt2:(2005-2009)"

Sökning: L773:1097 6825 > (2005-2009)

  • Resultat 1-10 av 55
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Abrahamsson, Thomas R, 1968-, et al. (författare)
  • Probiotics in prevention of IgE-associated eczema : a double-blind, randomized, placebo-controlled trial
  • 2007
  • Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 119:5, s. 1174-1180
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: An altered microbial exposure may underlie the increase of allergic diseases in affluent societies. Probiotics may alleviate and even prevent eczema in infants. OBJECTIVE: To prevent eczema and sensitization in infants with a family history of allergic disease by oral supplementation with the probiotic Lactobacillus reuteri. METHODS: Double-blind, randomized, placebo-controlled trial, which comprised 232 families with allergic disease, of whom 188 completed the study. The mothers received L reuteri ATCC 55730 (1 x 10(8) colony forming units) daily from gestational week 36 until delivery. Their babies then continued with the same product from birth until 12 months of age and were followed up for another year. Primary outcome was allergic disease, with or without positive skin prick test or circulating IgE to food allergens. RESULTS: The cumulative incidence of eczema was similar, 36% in the treated versus 34% in the placebo group. The L reuteri group had less IgE-associated eczema during the second year, 8% versus 20% (P = .02), however. Skin prick test reactivity was also less common in the treated than in the placebo group, significantly so for infants with mothers with allergies, 14% versus 31% (P = .02). Wheeze and other potentially allergic diseases were not affected. CONCLUSION: Although a preventive effect of probiotics on infant eczema was not confirmed, the treated infants had less IgE-associated eczema at 2 years of age and therefore possibly run a reduced risk to develop later respiratory allergic disease. CLINICAL IMPLICATION: Probiotics may reduce the incidence of IgE-associated eczema in infancy.
  •  
2.
  • Adlerberth, Ingegerd, 1959, et al. (författare)
  • Gut microbiota and development of atopic eczema in 3 European birth cohorts.
  • 2007
  • Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 120:2, s. 343-50
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Stimulation of the immune system by gut microbes might prevent allergy development. OBJECTIVE: The present study examined the hypothesis that sensitization to food allergens and atopic eczema are influenced by the infantile intestinal colonization pattern. METHODS: Infants were recruited perinatally in Göteborg (n = 116), London (n = 108), and Rome (n = 100). Commensal bacteria were identified to the genus or species level in rectal (3 days) and quantitative stool cultures (7, 14, and 28 days and 2, 6, and 12 months of age). At 18 months of age, atopic eczema and total and food-specific IgE levels were assessed. These outcomes were modeled in relation to time to colonization with 11 bacterial groups and to ratios of strict anaerobic to facultative anaerobic bacteria and gram-positive to gram-negative bacteria at certain time points. Study center, mode of delivery, parity, and infant diet were included as covariates. RESULTS: Neither atopic eczema nor food-specific IgE by 18 months of age were associated with time of acquisition of any particular bacterial group. Cesarean section delayed colonization by Escherichia coli and Bacteroides and Bifidobacterium species, giving way to, for example, Clostridium species. Lack of older siblings was associated with earlier colonization by Clostridium species and lower strict anaerobic/facultative anaerobic ratio at 12 months. CONCLUSIONS: This study does not support the hypothesis that sensitization to foods or atopic eczema in European infants in early life is associated with lack of any particular culturable intestinal commensal bacteria. CLINICAL IMPLICATIONS: The nature of the microbial stimulus required for protection from allergy remains to be identified.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  • Behre, Carl Johan, 1968 (författare)
  • Adiponectin: a defense protein in catabolism.
  • 2008
  • Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 122:6
  • Tidskriftsartikel (refereegranskat)
  •  
7.
  • Benson, Mikael, 1954, et al. (författare)
  • A network-based analysis of the late-phase reaction of the skin.
  • 2006
  • Ingår i: The Journal of allergy and clinical immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 118:1, s. 220-5
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The late-phase reaction (LPR) of the skin is an in vivo model of allergic inflammation. OBJECTIVE: We sought to identify disease-associated pathways in the LPR using a network-based analysis. METHODS: The LPR was examined by means of DNA microarray analysis of skin biopsy specimens from 10 patients with allergic rhinitis and 10 healthy control subjects. The results were further analyzed in 2 different materials consisting of nasal fluids and allergen-challenged CD4(+) T cells from patients with allergic rhinitis. RESULTS: The DNA microarray analysis revealed several genes of known relevance to allergy. The eosinophil marker Charcot-Leyden crystal protein (CLC) that encodes Charcot-Leyden crystal protein differed most in expression. A network-based analysis showed upregulation of IL-4- and CCL4-dependent pathways and downregulation of a TGF-beta-induced pathway. CCL4 is expressed by CD4(+) T cells and chemotactic for eosinophils. We hypothesized that allergen induces release of CCL4 from T(H)2 cells and that this contributes to influx of eosinophils. Further analysis showed increase of CCL4 protein in nasal fluids from allergic patients during the season. Allergen challenge of PBMCs resulted in proliferation of T(H)2 cells and increased production of CCL4 in CD4(+) T cells from allergic patients. An analysis of the DNA microarray data revealed a significant correlation between CCL4 and the eosinophil marker CLC. CONCLUSION: A network-based analysis of the LPR showed increased activity of IL-4- and CCL4- dependent pathways and downregulation of the TGF-beta-induced pathway. Allergen-induced release of CCL4 from T(H)2 cells might contribute to influx of eosinophils during the LPR. CLINICAL IMPLICATIONS: Involvement of multiple interacting pathways indicates that it might be difficult to identify one single mediator as a biomarker or drug target in allergic inflammation.
  •  
8.
  •  
9.
  •  
10.
  • Bjermer, Leif (författare)
  • Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation
  • 2007
  • Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 120:6, s. 1269-1275
  • Forskningsöversikt (refereegranskat)abstract
    • Inflammation is a key pathology in asthma. In the central airways local inflammation leads to irreversible remodeling and airway dysfunction. Complex inflammatory changes also occur in the nose, sinuses, and small airways. In particular, rhinitis and asthma are linked by a common pathogenic process with common inflammatory cells, mediators, and cytokines. Cross-communication between the airways and bone marrow through inflammatory mediators in the circulation leads to systemic propagation of airway inflammation. Treatment of asthma has traditionally focused on relieving bronchospasm with beta(2)-agonists, which do not affect inflammation. Treatment of eosinophilic inflammation in the central airways with inhaled corticosteroids reduces local inflammation and improves pulmonary function but does not improve the systemic manifestations of asthma. If asthma is a systemic disease, the underlying systemic pathology should be targeted by identifying common disease mediators, mechanisms, or both that are triggered only during active disease. Of currently available therapies, leukotriene receptor antagonists block the action of cysteinyl leukotrienes and thus improve both asthma and rhinitis and other conditions systemically linked with asthma. Other potential treatments include receptor-blocking molecules and synthesis inhibitors related to eicosanoid inflammation. Treatment of asthma as a systemic disease requires clinical trials that evaluate the effects of new treatments on both lung function and the wider systemic pathology.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 55
Typ av publikation
tidskriftsartikel (50)
konferensbidrag (3)
annan publikation (1)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (46)
övrigt vetenskapligt/konstnärligt (9)
Författare/redaktör
Jarvis, Deborah (10)
Janson, Christer (8)
Svanes, Cecilie (8)
Sunyer, Jordi (6)
Heinrich, Joachim (5)
Norbäck, Dan (5)
visa fler...
Zock, Jan-Paul (5)
de Marco, Roberto (4)
Villani, Simona (4)
Verlato, Giuseppe (4)
Olivieri, Mario (4)
Accordini, Simone (3)
Cazzoletti, Lucia (3)
Cerveri, Isa (3)
Corsico, Angelo (3)
Gislason, David (3)
Pin, Isabelle (3)
Marcon, Alessandro (3)
Gulsvik, Amund (3)
Bugiani, Massimilian ... (3)
von Mutius, E (3)
Wjst, Matthias (3)
Bjermer, Leif (2)
Hesselmar, Bill, 195 ... (2)
Notarangelo, LD (2)
Bjorksten, B (2)
Leynaert, Benedicte (2)
Scheynius, A (2)
Pejler, Gunnar (2)
Ahrné, Siv (2)
Adlerberth, Ingegerd ... (2)
Wold, Agnes E, 1955 (2)
Strachan, David P (2)
Åberg, Nils, 1943 (2)
Perkin, Michael R (2)
Tripodi, Salvatore (2)
Saalman, Robert, 195 ... (2)
Coates, Anthony R (2)
Åbrink, Magnus (2)
Dahlen, Sven-Erik (2)
Dahlman-Höglund, Ann ... (2)
Matheu, Victor (2)
Jögi, Rain (2)
Rak, Sabina, 1945 (2)
Benson, Mikael, 1954 (2)
Durham, Stephen R. (2)
Kumlin, Maria (2)
Dahlén, Barbro (2)
Martinez-Moratalla, ... (2)
Anto, Josep Maria (2)
visa färre...
Lärosäte
Karolinska Institutet (19)
Uppsala universitet (17)
Lunds universitet (13)
Göteborgs universitet (12)
Linköpings universitet (5)
Umeå universitet (2)
visa fler...
Sophiahemmet Högskola (2)
Kungliga Tekniska Högskolan (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (55)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (23)
Naturvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy