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- Ainamo, Antti, 1963-, et al.
(författare)
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Progress in the treatment and outcome of pediatric inflammatory bowel disease patients
- 2016
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Ingår i: Expert Review of Clinical Immunology. - Borås / Helsinki : Taylor & Francis. - 1744-666X .- 1744-8409. ; , s. 1-33
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Forskningsöversikt (refereegranskat)abstract
- This review discusses how treatment of pediatric inflammatory bowel disease (IBD) patients has improved with attention to therapeutic quality and cost. The number of such patients in Western countries has increased rapidly. Similarly to what has been the trend in the management of adult IBD, the pediatric IBD therapy has become more active than earlier. High use of immunosuppressants has helped to control the extensive and aggressive course of pediatric IBD. Full disease control already at an early phase has advantages such as to preserve normal child growth and development, to maintain overall good health and quality of life, as well as to decrease the psychosocial burden of the disease. A key research direction is to develop the more active approach into a way to reduce healthcare costs by decreasing the so-far high rate of surgery of pediatric IBD patients.
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| 2. |
- West, Christina E., et al.
(författare)
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Probiotics for treatment and primary prevention of allergic diseases and asthma : looking back and moving forward
- 2016
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Ingår i: Expert Review of Clinical Immunology. - : Taylor & Francis. - 1744-666X .- 1744-8409. ; 12:6, s. 625-639
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Forskningsöversikt (refereegranskat)abstract
- Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Here, we review treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context. Many meta-analyses have shown a moderate benefit of probiotics for eczema prevention, whereas there is less evidence of a benefit for other allergic manifestations. Because of very low quality evidence and heterogeneity between studies, specific advice on the most effective regimens cannot yet be given -not even for eczema prevention. To be able to adopt results into specific recommendations, international expert organizations stress the need for well-designed studies.
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| 7. |
- Brito-Zerón, Pilar, et al.
(författare)
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Early diagnosis of primary Sjögren's syndrome: EULAR-SS task force clinical recommendations.
- 2016
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Ingår i: Expert Review of Clinical Immunology. - 1744-8409. ; 12:2, s. 137-156
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Forskningsöversikt (refereegranskat)abstract
- Sjögren's syndrome (SjS) is a systemic autoimmune disease that mainly affects the exocrine glands, leading to generalized mucosal dryness. However, primary SjS may initially present with non-sicca (systemic) manifestations. When these features appear before the onset of an overt sicca syndrome, we may talk of an underlying 'occult' SjS. The European League Against Rheumatism (EULAR) has promoted and supported an international collaborative study group (EULAR-SS Task Force) aimed at developing consensual recommendations to provide a homogeneous approach to the patient with primary SjS presenting with systemic involvement. This review summarizes the key factors that should be taken into account in the diagnostic approach in a patient with suspected SjS according to the main clinical patterns of presentation, and is especially focused on organ-specific systemic disease presentations, including a consensus set of recommendations in order to reach an early diagnosis. Close collaboration with the different specialties involved through a comprehensive multidisciplinary approach is essential in SjS patients presenting with systemic involvements.
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