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Träfflista för sökning "LAR1:gu ;pers:(Thomsen Peter 1953)"

Sökning: LAR1:gu > Thomsen Peter 1953

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  • Adolfsson, E., et al. (författare)
  • Evaluation of bone ingrowth in Free Form Fabricated scaffolds
  • 2008
  • Ingår i: Key Engineering Materials. - 1662-9795.
  • Tidskriftsartikel (refereegranskat)abstract
    • Colloidal processing was used to cast zirconia and hydroxyapatite materials. The cast materials reached densities around 99% when sintered at 1500°C and 1200°C respectively. By controlling the colloidal process the sintered density of hydroxyapatite was also reduced to around 80% when the same sintering condition was used. The casting process was combined with free form fabrication to prepare designed scaffolds with identical macroporosity. These scaffolds were used to evaluate the early bone tissue response in rabbit femur. After six weeks of implantation the bone area in scaffolds of zirconia and hydroxyapatite were compared. In scaffolds of hydroxyapatite the bone area was roughly three times larger compared to corresponding scaffolds of zirconia. When the scaffolds of hydroxyapatite also contained an open microporosity of around 20% the amount of bone was even more pronounced. The results showed the importance of the material composition and the microstructure on the bone regenerating performance of scaffolds.
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  • Almqvist, Sofia, 1980, et al. (författare)
  • Amelogenin is phagocytized and induces changes in integrin configuration, gene expression and proliferation of cultured human dermal fibroblasts
  • 2010
  • Ingår i: Journal of Materials Science. Materials in Medicine. - : Springer Science and Business Media LLC. - 1573-4838 .- 0957-4530. ; 21:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Fibroblasts are central in wound healing by expressing important mediators and producing and remodelling extracellular matrix (ECM) components. This study aimed at elucidating possible mechanisms of action of the ECM protein amelogenin on normal human dermal fibroblasts (NHDF). Amelogenin at 100 and 1000 μg/ml increased binding of NHDF via several integrins, including αvβ3, αvβ5 and α5β1. Further, both surface interaction and cellular uptake of amelogenin by NHDF was observed using scanning and transmission electron microscopy. Gene microarray studies showed >8-fold up or down-regulation of genes, of which most are involved in cellular growth, migration and differentiation. The effect of amelogenin was exemplified by increased proliferation over 7 days. In conclusion, the beneficial effects of amelogenin on wound healing are possibly conducted by stimulating fibroblast signalling, proliferation and migration via integrin interactions. It is hypothesized that amelogenin stimulates wound healing by providing connective tissue cells with a temporary extracellular matrix.
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5.
  • Almqvist, Sofia, 1980, et al. (författare)
  • Amelogenins modulate cytokine expression in LPS-challenged cultured human macrophages.
  • 2012
  • Ingår i: Cytokine. - : Elsevier BV. - 1096-0023 .- 1043-4666. ; 58:2, s. 274-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Amelogenins are enamel matrix proteins with a proven ability to restore tissues in patients with advanced periodontitis and chronic skin wounds. To explore the mechanisms of action of amelogenins in wound inflammation, the in vitro effect on the expression of selected cell mediators involved in inflammation and tissue repair from human monocyte-derived macrophages was studied. Macrophages were treated with amelogenins in serum-enriched medium with simultaneous lipopolysaccharide (LPS) stimulation, for 6, 24 and 72 h, and the conditioned culture medium was analysed for 28 different cytokines. Amelogenin treatment directed the LPS-induced release of both pro- and anti-inflammatory cytokines towards an alternatively activated macrophage phenotype. This change in activation was also demonstrated by the amelogenin-induced secretion of alternative macrophage activation-associated CC chemokine-1 (AMAC-1, also known as CCL18; p<0.001), a well-documented marker of alternative activation. Amelogenins were also shown significantly to increase the macrophage expression of vascular endothelial growth factor and, to a lesser but significant extent, insulin-like growth factor-1 after 24h of culture. The results of the present in vitro study show that monocyte-derived macrophages stimulated by inflammatory agonist LPS respond to the treatment with amelogenins by reducing the pro-inflammatory activity and increasing the expression of tissue repair mediators.
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6.
  • Almqvist, Sofia, 1980, et al. (författare)
  • Amelogenins promote an alternatively activated macrophage phenotype in vitro.
  • 2011
  • Ingår i: International Journal of Nano and Biomaterials (IJNBM). - 1752-8933. ; 3:3, s. 282-298
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract: Amelogenins are extracellular matrix proteins used for the topical treatment of chronically inflamed tissues. The influence of amelogenins on human monocyte-derived macrophages was studied by measuring the concentrations of cytokines in culture supernatants. The interactions of cells and protein aggregates were visualised by transmission electron microscopy. The amelogenin treatment of macrophages increased several pro- and anti-inflammatory cytokines, including alternative macrophage activation marker AMAC-1 (p < 0.001) and vascular endothelial growth factor (VEGF; p < 0.001). The levels were independent of cytochalasin B, although amelogenin aggregates were ingested by macrophages. Amelogenin effect was compared with that of tyrosine-rich amelogenin peptide, which apart from augmented VEGF levels (p < 0.05), had no significant influence on the other cytokines analysed. In conclusion, amelogenins increased the macrophage release of key cell mediators involved in tissue repair. The effect was independent of phagocytosis, implying a receptor-mediated signal. The markedly increased levels of AMAC-1 suggest that amelogenins promote a reparative macrophage phenotype.
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  • Almqvist, Sofia, 1980, et al. (författare)
  • Effects of amelogenins on angiogenesis-associated processes of endothelial cells.
  • 2011
  • Ingår i: Journal of wound care. - 0969-0700. ; 20:2, s. 68, 70-5
  • Tidskriftsartikel (refereegranskat)abstract
    • To study the effects of an amelogenin mixture on integrin-dependent adhesion, DNA synthesis and apoptosis of cultured human dermal microvascular endothelial cells and angiogenesis in an organotypic assay.
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