| 1. |
- Abdel Ghani, Rania Mahmoud, et al.
(författare)
-
A structured evidence-based approach to decrease cardiovascular complications among pregnant women with reumatic disease : a pilot randomized controlled trial
- 2010
-
Ingår i: Journal of Medicine and Biomedical Science. - 2078-0273. ; :1, s. 8-15
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Recent reports from the developing world have documented rheumatic fever (RE) incidence rates as high as 206/100 000 and Rheumatic Heart Disease (RHD) prevalence rates as high as 18.6/1000. The high frequency of RHD in the developing world necessitates aggressive prevention and control measures. Aim: The aim of the study was to examine the effect of intensive antenatal follow up program on decreasing cardiovascular complications among rheumatic pregnant woman. Design: Randomized controlled trial. Setting: This study was conducted at El Kasr-EL Aini, maternity hospital- Cairo- University Hospitals. Sample: A total of 100 rheumatic pregnant women that attended the antenatal clinic at El Kasr-EL Aini, maternity hospital who could read and write, had functional class I and II cardiac disease, primigravida, nullipara with single fetus were recruited to this study and assigned randomly into two groups. Procedure: Women who met the inclusion criteria were interviewed and baseline assessment was done. Theintervention was an intensive antenatal follow up program for decreasing cardiovascular complications among rheumatic pregnant woman. Patients in the study group (SG) were offered an intervention at three levels, basic, intermediate and comprehensive. Evaluation of the program was carried out in term of assessment of maternal and neonatal outcome. Results: There were several significant differences between the study group (SG) and control group (CG). In the SG, antepartum complications was less common, gestational age at birth was higher, postnatal hospital stay shorter, birth weight higher, more had vaginal deliveries with episiotomy, fewer had caesarean section, forceps deliveries and termination of pregnancy, and cardiac class was better at follow up as compared to the CG. Conclusion: The difficult issues in pregnancy complications by cardiac disease are best managed through a team approach. Establishing a pre-pregnancy plan will foster a better therapeutic relationship between all parties and allow for better understanding of the patient’s beliefs regarding pregnancy, her disease and attitude towards medications.
|
|
| 2. |
- Abdel Ghani, Rania Mahmoud, et al.
(författare)
-
Parturient needs during labor : Egyptian women’s perspective toward childbirth experience, a step toward an excellence in clinical practice
- 2011
-
Ingår i: Journal of Basic and Applied Scientific Research. - 2090-4304. ; 1:12, s. 2935-2943
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Every woman giving birth has expectations. Identifying women’s expectations, wishes, needs and fears enable the health care provider(s) to work toward a common goal of safe and positive childbirth experience. Aim: The aim was to determine women’s preferences and needs during labor. Design: Analytic- cross sectional study. Setting: El Kasr- Aini, - Cairo- University Maternity Hospitals. Sample: A random sample of 400 women were recruited in the present study with the following criteria; age ranged between 20-30 years old, can read and write, primigravida, nulliparous woman with singleton low risk pregnancies, in the third trimester, up to 37 weeks of gestational age, no previous abortion and free from any medical complains. Procedure: Data collection took place in the antenatal clinic, each interview administrated questionnaire took a time between 10-15 minutes. Mothers completed the questionnaire in the antenatal clinics during their waiting for medical examination. Results: Twenty two need requirements emerged from the women's perspective. The highest ranked needs for parturient women during labor are; maintaining privacy through all procedures of 86.5%, accessibility of nurses demonstrate empathy of 67.5%, availability to ventilate and expressing fear and anxiety of 57.5%, quick response to request of 67.5%, frequent monitoring of 52.8%, accessibility of caring medical staff of 47.2% and short delivery of 52.8%. Conclusion: Despite good general coverage of labor care among women, there were clear variations in the type of management given to them or needed by them. This study confirms that different factors predict the multidimensionality of childbirth satisfaction.
|
|
| 3. |
- Abdel-Khalik, Jonas, et al.
(författare)
-
Incorporation of (14)C-cholesterol in human adrenal corticocarcinoma H295R cell line and online-radiodetection of produced (14)C-steroid hormone metabolites
- 2017
-
Ingår i: Journal of Pharmaceutical and Biomedical Analysis. - : Elsevier. - 0731-7085 .- 1873-264X. ; 145, s. 569-575
-
Tidskriftsartikel (refereegranskat)abstract
- This study demonstrates the addition of (14)C-cholesterol to the human cell line H295R will in-situ form radiolabeled steroid hormones allowing for new mechanistic and metabolic insights. The aim of the present study was to in-situ radiolabel steroid hormones from cell line-incorporated (14)C-cholesterol using the OECD guideline 456, H295R steroidogenesis in-vitro assay. Radiodetection of the steroid metabolites of the steroidogenic pathway allows for an improved understanding of the various enzymatic mechanisms involved without necessarily being dependent on quantification. Generated radiolabeled steroids were analyzed using HPLC hyphenated with a Flow Scintillation Analyzer (FSA). H295R cells were incubated with radiolabeled cholesterol and cell media were collected and prepared by solid phase extraction and analyzed with HPLC-FSA. For successful radiolabeling of the steroids in the steroidogenesis of H295R cells, radioactive cholesterol may potentially only need to be added just before the cells are incubated for 72h in well plates. Based on the obtained HPLC-FSA chromatograms, and confirmation of the observations by studies in the literature, a qualitative time profile for the production of steroid hormones was estimated. Multiple radiolabeled steroid hormones were identified by means of analytical standards and UV (ultraviolet) co-chromatography, though the elucidation of multiple metabolites remains unresolved. Although online radiodetection proved to suffer from suboptimal sensitivity, the concept of radiolabeling the steroidogenesis in H295R cells with (14)C-cholesterol and detecting the radiolabeled steroid hormones online was proved and may assist in further toxicological studies.
|
|
| 4. |
- Abdel–Khalik, Jonas, et al.
(författare)
-
Development of a solid phase extraction method for the simultaneous determination of steroid hormones in H295R cell line using liquid chromatography–tandem mass spectrometry
- 2013
-
Ingår i: Journal of chromatography. B. - : Elsevier BV. - 1570-0232. ; 935:September, s. 61-69
-
Tidskriftsartikel (refereegranskat)abstract
- The H295R in vitro cell line produces the majority of the steroidogenesis, for which reason it is commonly used as a screening tool for endocrine disrupting chemicals. Simultaneous determination of the precursor cholesterol and key steroid hormones could give a broad insight into the mechanistic disruption of the steroidogenesis. Steroid hormones have primarily been extracted from H295R incubation medium by means of liquid-liquid extraction (LLE) and the obtained recoveries and matrix effects have typically not been stated or assessed. In the present study a solid-phase extraction (SPE) method was developed and validated for the simultaneous extraction of cholesterol and five key steroid hormones pregnenolone, 17-hydroxyprogesterone, testosterone, cortisol and aldosterone from H295R incubation medium, and finally detected by LC-MS/MS. Cholesterol was recovered at a level of 55.7%, while steroid hormone recoveries ranged from 98.2 to 109.4%. Matrix effects varied between -0.6% and 62.8%. Intra-day precision was deemed acceptable, but the inter-day precision for pregnenolone and aldosterone exceeded the precision limit of 15% RSD. Although LLE has been the most frequently used extraction method in H295R studies, however, our investigation has shown that SPE may relatively easily extract and recover steroid hormones, potentially replacing LLE.
|
|
| 5. |
- Abdel–Khalik, Jonas, et al.
(författare)
-
Simultaneous determination of endogenous steroid hormones in human and animal plasma and serum by liquid or gas chromatography coupled to tandem mass spectrometry
- 2013
-
Ingår i: Journal of chromatography. B. - : Elsevier BV. - 1570-0232. ; 928:June, s. 59-77
-
Tidskriftsartikel (refereegranskat)abstract
- Analytical methodologies based on liquid or gas chromatography coupled to tandem mass spectrometry for the simultaneous determination of two or more endogenous steroid hormones in human and animal plasma and serum has received increased attention the last few years. Especially in the clinical setting steroid profiling is of major importance in disease diagnostics. This paper discusses recent findings in such multi-steroid hormone procedures published from 2001 to 2012. The aim was to elucidate possible relationships between chosen analytical technique and the obtained analyte sensitivity for endogenous steroid hormones. By evaluating the success, at which the currently applied techniques have been utilized, more general knowledge on the field is provided. Furthermore the evaluation provides directions in which future studies may be interesting to conduct.
|
|
| 6. |
- Abrahamson, Martin, 1977-
(författare)
-
Offer Price and Post-IPO Ownership Structure
- 2024
-
Ingår i: Journal of Risk and Financial Management. - : MDPI. - 1911-8074 .- 1911-8066. ; 17:2, s. 61-61
-
Tidskriftsartikel (refereegranskat)abstract
- In an initial public offering (IPO) the firm can set the offer price of its shares, based on the valuation of the firm, by changing the number of shares. This study uses stock ownership records and hand-collected IPO data to analyze the offer prices, the underpricing of IPO shares (measured as the initial return, IR) and the relationship with the post-IPO ownership structure. Specifically, the paper focuses on individual IPO investors. The results show that for the lowest priced IPOs the IR is significantly higher priced IPOs. Furthermore, for the low-priced IPOs, there is a negative relationship between offer price and breadth of ownership. This implies that stocks with a low price can attract more investors than stocks with higher offer prices. However, for high-priced IPOs the relationship is positive, suggesting that also the IPOs with highest price attract more investors. Overall, this study shows that the offer price of an IPO firm may have a moderate effect on its post-IPO ownership structure.
|
|
| 7. |
- Abrahamsson, Agneta, et al.
(författare)
-
A salutogenic perspective could be of practical relevance for the prevention of smoking amongst pregnant women
- 2002
-
Ingår i: Midwifery. - : Churchill Livingstone. - 0266-6138 .- 1532-3099. ; 18:4, s. 323-331
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: to use empirical data to assess the theoretical relevance of using a salutogenic, instead of a pathogenic, perspective to prevent smoking during pregnancy. DESIGN: quantitative study, a questionnaire was completed during the first trimester of pregnancy and an interview was conducted after the baby was born. SETTING: a geographically defined area in the south-east of Sweden. PARTICIPANTS: all 395 women in the study area who were pregnant during the study period 1994-1995. FINDINGS: the women were categorised according to their smoking habits. A significant difference in the sense of coherence (SOC) score was shown between smoking and non-smoking women in indicators of bad health. Women who relapsed to smoking showed a lower level of SOC, particularly in the manageability component, than others. The SOC score was higher in the whole study group than in other comparable, non-pregnant populations. KEY CONCLUSIONS AND IMPLICATIONS FOR PRACTICE: a salutogenic perspective could be used in antenatal care as a basis for encouraging pregnant women to stop smoking. This could enhance the SOC by making smoking more understandable for the woman, by discussing smoking as a way of coping, and by encouraging the woman's own capacity and motivation to stop smoking. Starting a dialogue about smoking from the woman's point of view could do this, with the midwife and the woman exploring together the woman's thoughts about the smoking problem.
|
|
| 8. |
- Abrahamsson, Agneta, et al.
(författare)
-
Building bridges or negotiating tensions? : experiences from a project aimed at enabling migrant access to health and social care in Sweden
- 2009
-
Ingår i: Diversity in Health and Care. - 1759-1422. ; 6:2, s. 85-95
-
Tidskriftsartikel (refereegranskat)abstract
- A current challenge for many European countries is to enable forced migrants to access health and social care that meets their needs. One solution is to use paraprofessionals - that is, trained individuals who are not professionals - to act as bridge-builders between minority communities and the health and social care sectors. This paper explores the development of a quality improvement project in Sweden. The project aimed to recruit and train forced migrants who had lived in Sweden for more than five years to act as bridge-builders. The aim was to use their unique experiences and knowledge in two ways - to work with service staff in developing new ways of working, and to become culturally competent paraprofessionals working with their own communities. This paper focuses on how an understanding of the role evolved as the participants reflected on their experiences and undertook an inquiry process culminating in the development of three possible models of what the task of a bridge-builder should be in developing culturally appropriate health and social services that are responsive to the needs of forced migrants. The conclusion reflects on what was learned and how the experiences from this project may be useful for others who are struggling with the same kind of problem in Sweden and in other countries.
|
|
| 9. |
- Abrahamsson, Agneta
(författare)
-
"Det var inte så lätt som vi trodde" : tvärsektoriell samverkan på en familjecentral
- 2007
-
Ingår i: Socialmedicinsk Tidskrift. - 0037-833X. ; 84:6, s. 529-540
-
Tidskriftsartikel (refereegranskat)abstract
- Samarbete och samverkan tas ofta för givet som något gott. Men trots höga förväntningar på positiva effekter är det svårare än vad många förväntar sig. Familjecentralen som den här artikeln handlar om är ett exempel på hur tvärsektoriell samverkan kan se ut i praktiken. Personalen har tillsammans med en forskare studerat samarbetets grundvalar och i artikeln diskuteras det spänningsfält som personalen på grund av samlokalisering befinner sig i och som innebär såväl hinder som möjligheter för samarbete. För att skapa gynnsamma förutsättningar för tvärsektoriellt samarbete i en samlokaliserad verksamhet behöver följande aspekter diskuteras och övervägas. - Moderorganisationernas ledning behöver se över ekonomiska och administrativa rutiner för familjecentralen och skapa yttre förutsättningar i form av handledning och tid för lärande och utveckling inom gruppen. - Personalen behöver tänka över betydelsen av sin egen och professionens utveckling samt aspekter av den organisationskultur som de representerar och bär upp. Olikheter kan bli bränsle för lärande och utveckling i gruppen, som i sin tur kan leda till en utveckling och nytänkande i verksamheten och man kan undvika att olikheter blir grogrund för samarbetsproblem.
|
|
| 10. |
- Abrahamsson, Agneta, et al.
(författare)
-
Familjecentralen : mervärde för alla föräldrar genom samlokalisering?
- 2011
-
Ingår i: Socialmedicinsk Tidskrift. - 0037-833X. ; 88:2, s. 100-109
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Barnens hälsa påverkas redan tidigt i livet av föräldrarnas livsvillkor. Låg social status, brist på vänner och stress tidigt i livet leder till hälsoskillnader. Familjecentraler med en öppen förskola och förebyggande socialt arbete är en tidig insats och en lågriskstrategi som riktar sig till alla. Den har goda förutsättningar för att stärka föräldrarnas tillit och gemenskap med andra och kan bidra till att minska hälsoskillnader genom att främja barnens hälsoutveckling. Syftena med utvärderingen av de 16 familjecentralerna var att undersöka i vilken mån besökarna är representativa för befolkningen i upptagningsområdet och av vilka anledningar föräldrarna besöker öppna förskolan på familjecentralen. Jämförelse mellan befintlig befolkningsdata i upptagningsområdena och föräldrabesökares bakgrundsdata visar att familjecentralen i huvudsak når en representativ del av befolkningen. Föräldrar använder sig av familjecentralen för att få råd, utbyte av erfarenheter, barnens skull och att umgås med andra. I synnerhet för invandrare har familjecentralen stor betydelse för att komma in i det svenska samhället.
|
|
