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Träfflista för sökning "LAR1:ki ;pers:(Olsson T)"

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Numrering	Referens	Omslagsbild	Hitta
1.	Abdelmagid, N, et al. (författare) Neuinflam9/Toxo1 regulates the innate immune response after nerve injury and susceptibility to autoimmune neuroinflammation in rat 2012 Ingår i: JOURNAL OF NEUROIMMUNOLOGY. - 0165-5728. ; 253:1-2, s. 79-79 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
2.	Abdelmagid, N., et al. (författare) The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat 2012 Ingår i: Plos Pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 8:6 Tidskriftsartikel (refereegranskat)abstract Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development.
3.	Abdelmagid, N., et al. (författare) Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis 2016 Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 11:5 Tidskriftsartikel (refereegranskat)abstract Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain. Although viral latency in neurons is very common in the population, it remains unclear why certain individuals develop HSE. Here we explore potential host genetic variants predisposing to HSE. In order to investigate this we used a rat HSE model comparing the HSE susceptible SHR (Spontaneously Hypertensive Rats) with the asymptomatic infection of BN (Brown Norway). Notably, both strains have HSV-1 spread to the CNS at four days after infection. A genome wide linkage analysis of 29 infected HXB/BXH RILs (recombinant inbred lines-generated from the prior two strains), displayed variable susceptibility to HSE enabling the definition of a significant QTL (quantitative trait locus) named Hse6 towards the end of chromosome 4 (160.89-174Mb) containing the Vwf (von Willebrand factor) gene. This was the only gene in the QTL with both cis-regulation in the brain and included several non-synonymous SNPs (single nucleotide polymorphism). Intriguingly, in human chromosome 12 several SNPs within the intronic region between exon 43 and 44 of the VWF gene were associated with human HSE pathogenesis. In particular, rs917859 is nominally associated with an odds ratio of 1.5 (95% CI 1.11-2.02; p-value = 0.008) after genotyping in 115 HSE cases and 428 controls. Although there are possibly several genetic and environmental factors involved in development of HSE, our study identifies variants of the VWF gene as candidates for susceptibility in experimental and human HSE.
4.	Abdul-Majid, KB, et al. (författare) Comparing the pathogenesis of experimental autoimmune encephalomyelitis in CD4-/- and CD8-/- DBA/1 mice defines qualitative roles of different T cell subsets 2003 Ingår i: Journal of neuroimmunology. - : Elsevier BV. - 0165-5728. ; 141:1-2, s. 10-19 Tidskriftsartikel (refereegranskat)
5.	Abdul-Majid, KB, et al. (författare) Fc receptors are critical for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis 2002 Ingår i: Scandinavian journal of immunology. - : Wiley. - 0300-9475. ; 55, s. 70- Tidskriftsartikel (refereegranskat)
6.	Abdul-Majid, KB, et al. (författare) Screening of several H-2 congenic mouse strains identified H-2(q) mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement 2000 Ingår i: Journal of neuroimmunology. - 0165-5728. ; 111:1-2, s. 23-33 Tidskriftsartikel (refereegranskat)
7.	Adams, C, et al. (författare) Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans 2024 Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - 1091-6490. ; 121:8, s. e2302259121- Tidskriftsartikel (refereegranskat)
8.	Adams, CJ, et al. (författare) Pregnancy does not modify the risk of MS in genetically susceptible women 2020 Ingår i: Neurology(R) neuroimmunology & neuroinflammation. - 2332-7812. ; 7:6 Tidskriftsartikel (refereegranskat)
9.	Adzemovic, MZ, et al. (författare) Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats 2012 Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7, s. e39794- Tidskriftsartikel (refereegranskat)
10.	Adzemovic, MZ, et al. (författare) Imatinib ameliorates neuroinflammation in a rat model of multiple sclerosis by enhancing blood-brain barrier integrity and by modulating the peripheral immune response 2014 Ingår i: JOURNAL OF NEUROIMMUNOLOGY. - : Elsevier BV. - 0165-5728. ; 275:1-2, s. 32-32 Konferensbidrag (övrigt vetenskapligt/konstnärligt)

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Typ av publikation: tidskriftsartikel (451); konferensbidrag (303)

Typ av innehåll: refereegranskat (402); övrigt vetenskapligt/konstnärligt (352)

Författare/redaktör: Olsson, T (753)Ta bort avgränsningen; Hillert, J (235); Kockum, I. (200); Piehl, F (193); Alfredsson, L (166); Khademi, M. (133); visa fler...; Jagodic, M (93); Lycke, J (68); Hedstrom, AK (57); Manouchehrinia, A (54); Nilsson, P. (50); Martin, C (48); Svenningsson, A (48); Stridh, P (46); Dahle, C. (46); Wallstrom, E (41); Forsberg, L. (40); Gunnarsson, M (34); Comi, G (32); Harbo, HF (29); Sellebjerg, F (29); Brundin, L (28); Celius, EG (28); Kagstrom, S (28); Burman, J. (27); Kappos, L (26); Lassmann, H (25); Linington, C (25); Andersson, M (25); Barcellos, LF (25); Huang, J. (24); Fogdell-Hahn, A (22); Lidman, O (21); Berglund, A. (21); Sorensen, PS (20); Waterboer, T (20); Holmdahl, R (19); Schaefer, C (19); Kuhle, J. (19); Sondergaard, HB (19); Landtblom, AM (19); KLARESKOG, L (18); Hemmer, B (18); Guerreiro-Cacais, AO (18); Bomfim, IL (18); Fink, K (18); Link, J (18); Diez, M (17); Martin, R (17); D'alfonso, S (17); visa färre...

Lärosäte: Karolinska Institutet (754); Uppsala universitet (28); Umeå universitet (24); Göteborgs universitet (21); Kungliga Tekniska Högskolan (19); Örebro universitet (11); visa fler...; Lunds universitet (7); Linköpings universitet (4); Stockholms universitet (1); Södertörns högskola (1); visa färre...

Språk: Engelska (754)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (90); Naturvetenskap (7)

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