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Magnus Linnarsson
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Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo.
- Woll, Petter S (author)
-
- Kjällquist, Una (author)
- Karolinska Institutet
- Chowdhury, Onima (author)
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- Doolittle, Helen (author)
- Wedge, David C (author)
- Thongjuea, Supat (author)
- Erlandsson, Rikard (author)
- Mead, Adam J (author)
- Stenson, Laura (author)
- Giustacchini, Alice (author)
- Duarte, Sara (author)
- Giannoulatou, Eleni (author)
- Taylor, Stephen (author)
- Scharenberg, Christian (author)
- Macaulay, Iain C (author)
- Clark, Sally-Ann (author)
- Dybedal, Ingunn (author)
- Josefsen, Dag (author)
- Fenaux, Pierre (author)
- Hokland, Peter (author)
- Holm, Mette S (author)
- Cazzola, Mario (author)
- Malcovati, Luca (author)
- Tauro, Sudhir (author)
- Bowen, David (author)
- Boultwood, Jacqueline (author)
- Pellagatti, Andrea (author)
- Pimanda, John E (author)
- Unnikrishnan, Ashwin (author)
- Vyas, Paresh (author)
- Göhring, Gudrun (author)
- Schlegelberger, Brigitte (author)
- Kvalheim, Gunnar (author)
- Constantinescu, Stefan N (author)
- Campbell, Peter J (author)
- Papaemmanuil, Elli (author)
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- (creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
- In: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 25:6, s. 794-808
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
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- By the author/editor
- Woll, Petter S
- Kjällquist, Una
- Chowdhury, Onima
- Doolittle, Helen
- Wedge, David C
- Thongjuea, Supat
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- Ngara, Mtakai
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- Macaulay, Iain C
- Clark, Sally-Ann
- Dybedal, Ingunn
- Josefsen, Dag
- Fenaux, Pierre
- Hokland, Peter
- Holm, Mette S
- Cazzola, Mario
- Malcovati, Luca
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- Pellagatti, Andr ...
- Pimanda, John E
- Unnikrishnan, As ...
- Vyas, Paresh
- Göhring, Gudrun
- Schlegelberger, ...
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- Hellström-Lindbe ...
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- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Cancer Cell
- By the university
- Lund University
- Karolinska Institutet
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