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Sökning: WFRF:(Örndahl Eva)

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  • Gustafsson, Agnetha, et al. (författare)
  • A multicentre simulation study of planar whole-body bone scintigraphy in Sweden
  • 2022
  • Ingår i: EJNMMI Physics. - : Springer. - 2197-7364 .- 2191-219X. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Whole-body bone scintigraphy is a clinically useful non-invasive and highly sensitive imaging method enabling detection of metabolic changes at an early stage of disease, often earlier than with conventional radiologic procedures. Bone scintigraphy is one of the most common nuclear medicine methods used worldwide. Therefore, it is important that the examination is implemented and performed in an optimal manner giving the patient added value in the subsequent care process. The aim of this national multicentre survey was to investigate Swedish nuclear medicine departments compliance with European practice guidelines for bone scintigraphy. In addition, the effect of image acquisition parameters on the ability to detect metabolic lesions was investigated. Methods: Twenty-five hospital sites participated in the study. The SIMIND Monte Carlo (MC) simulation and the XCAT phantom were used to simulate ten fictive patient cases with increased metabolic activity distributed at ten different locations in the skeleton. The intensity of the metabolic activity was set into six different levels. Individual simulations were performed for each site, corresponding to their specific camera system and acquisition parameters. Simulated image data sets were then sent to each site and were visually evaluated in terms of if there was one or several locations with increased metabolic activity relative to normal activity. Result: There is a high compliance in Sweden with the EANM guidelines regarding image acquisition parameters for whole-body bone scintigraphy. However, up to 40% of the participating sites acquire lower count density in the images than recommended. Despite this, the image quality was adequate to maintain a stable detection level. None of the hospital sites or individual responders deviated according to the statistical analysis. There is a need for at least 2.5 times metabolic activity compared to normal for a lesion to be detected. Conclusion: The imaging process is well harmonized throughout the country and there is a high compliance with the EANM guidelines. There is a need for at least 2.5 times the normal metabolic activity for a lesion to be detected as abnormal.
  • Bergvall, Nils, et al. (författare)
  • Emission line flux limits in four QSO metal line absorbers
  • 1997
  • Ingår i: ASTRONOMY AND ASTROPHYSICS. - : SPRINGER VERLAG. - 0004-6361. ; 321:3, s. 771-775
  • Tidskriftsartikel (refereegranskat)abstract
    • In an effort to detect the early phases of star formation in massive galaxies, we have searched for Ly alpha and [O II]lambda 3727 emission from four QSO metal absorption line systems and possible associated galaxies, using narrow-band filters. None of th
  • Looi, Jeffrey Chee Leong, et al. (författare)
  • Shape analysis of the neostriatum in subtypes of frontotemporal lobar degeneration : neuroanatomically significant regional morphologic change
  • 2011
  • Ingår i: Psychiatry Research. - 0925-4927 .- 1872-7506. ; 191:2, s. 98-111
  • Tidskriftsartikel (refereegranskat)abstract
    • Frontostriatal circuit mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD) and may differ across subtypes of FTLD. We manually segmented the neostriatum (caudate nucleus and putamen) in FTLD subtypes: behavioral variant frontotemporal dementia, FTD, n=12; semantic dementia, SD, n=13; and progressive non-fluent aphasia, PNFA, n=9); in comparison with controls (n=27). Diagnoses were based on international consensus criteria. Manual bilateral segmentation of the caudate nucleus and putamen was conducted blind to diagnosis by a single analyst, on MRI scans using a standardized protocol. Intracranial volume was calculated via a stereological point counting technique and was used for normalizing the shape analysis. Segmented binaries were analyzed using the Spherical Harmonic (SPHARM) Shape Analysis tools (University of North Carolina) to perform comparisons between FTLD subtypes and controls for global shape difference, local significance maps and mean magnitude maps of shape displacement. Shape analysis revealed that there was significant shape difference between FTLD subtypes and controls, consistent with the predicted frontostriatal dysfunction and of significant magnitude, as measured by displacement maps. These differences were not significant for SD compared to controls; lesser for PNFA compared to controls; whilst FTD showed a more specific pattern in regions relaying fronto- and corticostriatal circuits. Shape analysis shows regional specificity of atrophy, manifest as shape deflation, with a differential between FTLD subtypes, compared to controls.
  • Ronnback, Jari, et al. (författare)
  • Host galaxies of intermediate redshift radio-loud and radio-quiet quasars
  • 1996
  • Tidskriftsartikel (refereegranskat)abstract
    • In a search for host galaxies associated with quasars, we present results from deep CCD imaging using the European Southern Observatory (ESO) 3.5-m New Technology Telescope (NTT). 21 targets, 12 radio-loud and nine radio-quiet quasars, were observed in R,
  • Trägårdh, Elin, et al. (författare)
  • Evaluation of inter-departmental variability of ejection fraction and cardiac volumes in myocardial perfusion scintigraphy using simulated data.
  • 2015
  • Ingår i: EJNMMI Physics. - : Springer. - 2197-7364. ; 2:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Myocardial perfusion scintigraphy (MPS) is a clinically useful noninvasive imaging modality for diagnosing patients with suspected coronary artery disease. By utilizing gated MPS, the end diastolic volume (EDV) and end systolic volume (ESV) can be measured and the ejection fraction (EF) calculated, which gives incremental prognostic value compared with assessment of perfusion only. The aim of this study was to evaluate the inter-departmental variability of EF, ESV, and EDV during gated MPS in Sweden.
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