| 1. |
|
|
| 2. |
|
|
| 3. |
- Andersson, Rebecka, 1988, et al.
(author)
-
Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature.
- 2017
-
In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
-
Journal article (peer-reviewed)abstract
- Cytochrome c oxidase catalyses the reduction of molecular oxygen to water while the energy released in this process is used to pump protons across a biological membrane. Although an extremely well-studied biological system, the molecular mechanism of proton pumping by cytochrome c oxidase is still not understood. Here we report a method to produce large quantities of highly diffracting microcrystals of ba 3-type cytochrome c oxidase from Thermus thermophilus suitable for serial femtosecond crystallography. The room-temperature structure of cytochrome c oxidase is solved to 2.3 Å resolution from data collected at an X-ray Free Electron Laser. We find overall agreement with earlier X-ray structures solved from diffraction data collected at cryogenic temperature. Previous structures solved from synchrotron radiation data, however, have shown conflicting results regarding the identity of the active-site ligand. Our room-temperature structure, which is free from the effects of radiation damage, reveals that a single-oxygen species in the form of a water molecule or hydroxide ion is bound in the active site. Structural differences between the ba 3-type and aa 3-type cytochrome c oxidases around the proton-loading site are also described.
|
|
| 4. |
|
|
| 5. |
- Andersson, SO, et al.
(author)
-
Body size and prostate cancer: A 20-year follow-up study among 135006 Swedish construction workers
- 1997
-
In: JOURNAL OF THE NATIONAL CANCER INSTITUTE. - : NATL CANCER INSTITUTE. - 0027-8874. ; 89:5, s. 385-389
-
Journal article (peer-reviewed)abstract
- Background: Obesity is associated with endocrine changes (e.g., increased estrogen and decreased testosterone in the blood) that have been implicated in the cause of prostate cancer and, therefore, an association between body weight and the risk of develo
|
|
| 6. |
- ANDERSSON, SO, et al.
(author)
-
EARLY-LIFE RISK-FACTORS FOR PROSTATE-CANCER - A POPULATION-BASED CASE-CONTROL STUDY IN SWEDEN
- 1995
-
In: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. - : AMER ASSOC CANCER RESEARCH. - 1055-9965. ; 4:3, s. 187-192
-
Journal article (other academic/artistic)abstract
- We undertook a population-based case-control study to investigate early life risk factors for prostate cancer. Information on dietary habits during childhood and adolescence, childhood environment, pubertal development, and physical activity was collected
|
|
| 7. |
- Andersson, SO, et al.
(author)
-
Lifestyle factors and prostate cancer risk: A case-control study in Sweden
- 1996
-
In: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. - : AMER ASSOC CANCER RESEARCH. - 1055-9965. ; 5:7, s. 509-513
-
Journal article (peer-reviewed)abstract
- We examined associations between lifestyle factors and subsequent risk of prostate cancer in a population-based case-control study, Information on smoking and alcohol habits, socioeconomic factors, marital status, family history, and sexual habits were ob
|
|
| 8. |
- Andersson, SO, et al.
(author)
-
Patients frequently consulting general practitioners at a primary health care centre in Sweden--a comparative study
- 1995
-
In: Scandinavian journal of social medicine. - : SAGE Publications. - 0300-8037. ; 23:4, s. 251-257
-
Journal article (peer-reviewed)abstract
- The purpose of this study was to describe the sociodemographic patterns, consultations and the nature of problems of frequent attenders (FAs) at general practitioners at a primary health care centre. The design was a comparative study of FAs (≥5 consultations during 1991) ( n = 179) and a contrast group of patients (CPs) matched by age and sex (1-4 consultations during 1991, n = 179). Data from medical records, appointment system, mortality and marital status were recorded. FAs comprised 1.7% of the inhabitants. Boys, middle-aged females, retired males and females and especially very old females were more frequent among FAs than their sections of the population would imply. FAs accounted for 15% and CPs for 4% of the consultations, 6.3 and 1.7 consultations on average, respectively. The average booked time for consultations during 1991 was 140 minutes for FAs and 35 minutes for CPs. Continuity was higher among older than younger FAs. Contacts other than medical consultations comprised a substantial part of the work with FAs, especially among middle-aged and elderly FAs. Problems arising from the musculoskeletal system, psychological and social problems were most common among FAs, often in combination, while chronic diseases such as cardiovascular diseases and diabetes were not crucial for frequent attending. Few FAs consulted as frequently in the preceding years and the following year, as in 1991, but still they accounted for more consultations than CPs during these years. More female FAs than males and CPs were divorced. The study indicates that FAs require a long-term strategy where continuity and accessibility are often important. They might also have profited by more time. However, FAs were a heterogeneous group of patients and follow-up studies and individual studies of FAs would be of interest.
|
|
| 9. |
|
|
| 10. |
|
|
