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Sökning: WFRF:(Abrahamsson Niclas)

  • Resultat 1-10 av 83
  • [1]234567...9Nästa
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  • Abrahamsson, Niclas, 1976-, et al. (författare)
  • Video-based CBT-E improves eating patterns in obese patients with eating disorder : A single case multiple baseline study
  • 2018
  • Ingår i: Journal of Behavior Therapy and Experimental Psychiatry. - 0005-7916 .- 1873-7943. ; 61, s. 104-112
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND OBJECTIVES:Cognitive Behavioral Therapy (CBT) is effective for treating eating disorders but it may be difficult to reach patients living far from urban centers. Mobile video-based psychotherapy may potentially improve service reach but has not yet been evaluated. The purpose of this study was to investigate the effects of mobile video-based CBT for eating disorder and to explore the feasibility to use this technology in clinical care.METHODS:A controlled single case multiple baseline design was used which allowed for statistical analyses with randomization tests and non-overlap of all pairs (NAP). Five patients in the first stage of eating disorder treatment were included and the main outcome variable was daily meal frequency. Secondary outcome variables included eating disorder symptoms, psychological distress and treatment satisfaction.RESULTS:The treatment resulted in a significant (p < .01) increase in daily meal frequency with medium to large effect sizes (combined NAP = .89). Four participants reported reliable improvements in eating disorder symptoms and three reported improvements in mood. The participants reported high satisfaction with the treatment and with the mobile video-application despite some technical problems.LIMITATIONS:Self-reported data on eating behavior is prone to be biased and the results of single case studies may have limited generalizability.CONCLUSION:CBT can be delivered effectively via a mobile video application and, despite some technological issues, can be well received by patients. All participants in this study had previous low access to mental health services and reported high satisfaction with the treatment format.
  • Garcia-Bennett, Alfonso E., et al. (författare)
  • In vitro generation of motor neuron precursors from mouse embryonic stem cells using mesoporous nanoparticles
  • 2014
  • Ingår i: Nanomedicine. - 1743-5889 .- 1748-6963. ; 9:16, s. 2457-2466
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: Stem cell-derived motor neurons (MNs) are utilized to develop replacement strategies for spinal cord disorders. Differentiation of embryonic stem cells into MN precursors involves factors and their repeated administration. We investigated if delivery of factors loaded into mesoporous nanoparticles could be effective for stem cell differentiation in vitro. Materials & methods: We used a mouse embryonic stem cell line expressing green fluorescent protein under the promoter for the MN-specific gene Hb9 to visualize the level of MN differentiation. The differentiation of stem cells was evaluated by expression of MN-specific transcription factors monitored by quantitative real-time PCR reactions and immunocytochemistry. Results: Mesoporous nanoparticles have strong affiliation to the embryoid bodies, penetrate inside the embryoid bodies and come in contact with differentiating cells. Conclusion: Repeated administration of soluble factors into a culture medium can be avoided due to a sustained release effect using mesoporous silica.
  • Pereira, M. J., et al. (författare)
  • Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes. Degree of hyperglycemia and adiposity are important factors
  • 2016
  • Ingår i: Metabolism: Clinical and Experimental. - 0026-0495 .- 1532-8600. ; 65:12, s. 1768-1780
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Elevated levels of circulating non-esterified fatty acids (NEFA) mediate many adverse metabolic effects. In this work we aim to determine the impact of type 2 diabetes (T2D), glycemic control and obesity on lipolysis regulation. Design and Participants 20 control and 20 metformin-treated T2D subjects were matched for sex (10 M/10 F), age (58 ± 11 vs 58 ± 9 y) and BMI (30.8 ± 4.6 vs 30.7 ± 4.9 kg/m2). In vivo lipolysis was assessed during a 3 h-OGTT with plasma glycerol and NEFA levels. Subcutaneous adipose tissue (SAT) biopsies were obtained to measure mRNA and metabolite levels of factors related to lipolysis and lipid storage and to assess in vitro lipolysis in isolated subcutaneous adipocytes. Results Plasma NEFA AUC during the OGTT where higher 30% (P = 0.005) in T2D than in control subjects, but plasma glycerol AUC and subcutaneous adipocyte lipolysis in vitro were similar, suggesting that adipose tissue lipolysis is not altered. Expression in SAT of genes involved in lipid storage (FABP4, DGAT1, FASN) were reduced in T2D subjects compared with controls, but no differences were seen for genes involved in lipolysis. T2D subjects had elevated markers of beta-oxidation, α-hydroxybutyrate (1.4-fold, P < 0.01) and β-hydroxybutyrate (1.7-fold, P < 0.05) in plasma. In multivariate analysis, HbA1c, visceral adipose tissue volume and sex (male) were significantly associated with NEFA AUC in T2D subjects. Conclusions In T2D subjects, NEFA turnover is impaired, but not due to defects in lipolysis or lipid beta-oxidation. Impaired adipose NEFA re-esterification or de novo lipogenesis is likely to contribute to higher NEFA plasma levels in T2D. The data suggest that hyperglycemia and adiposity are important contributing factors for the regulation of plasma NEFA concentrations. © 2016 Elsevier Inc.
  • Abrahamsson, Niclas, 1968- (författare)
  • Acquiring L2 Syllable Margins : Studies on the simplification of onsets and codas in interlanguage phonology
  • 2001
  • Doktorsavhandling (övrigt vetenskapligt)abstract
    • This thesis deals with developmental, universal, grammatical, and functional factors involved in the acquisition of L2 syllable structure. More specifically, using speech data from Spanish and Chinese learners of Swedish, the thesis examines the production and development of syllable onsets and codas—that is, syllable margins. In doing so, the present work draws on various theoretical considerations and empirical findings from research on L1 and L2 acquisition, phonology and phonetics, language variation and language typology. The thesis includes three empirical studies, all of which are based on longitudinal conver­sational data. Study I deals with the acquisition of word-initial /sC(C)/ onsets by one native Spanish speaker, whereas Study II and Study III focus on the acquisi­tion of word-final codas by three native Chinese speakers. Study I and Study II both showed that onset and coda length and phonetic environment are influen­tial factors in the production of syllable structure, while sonority may not be as reliable a predictor of production difficulty. Next, both Study I and Study III provide evidence of a U-shaped rather than linear development of pronunciation accuracy. This pattern is interpreted as an effect of initial increase in fluency, with more focus on content and less on form. In addition, Study III showed that L2 proficiency is related to the epenthesis-deletion differential. An increasing ratio of epenthesis-to-deletion is the first-order indicator of increasing L2 profi­ciency during early stages of acquisition, but increased target-like production becomes the first-order indicator of development at later stages. Finally, Study III showed that learners are aware of potential ambiguity resulting from simpli­fication in different grammatical/functional categories. Codas that are essential for the retention of semantic information are preserved through higher accuracy rates and higher relative levels of epenthesis errors.
  • Abrahamsson, Niclas (författare)
  • Age of onset and nativelike L2 ultimate attainment of morphosyntactic and phonetic intuition
  • 2012
  • Ingår i: Studies in Second Language Acquisition. - 0272-2631 .- 1470-1545. ; 34:2, s. 187-214
  • Tidskriftsartikel (refereegranskat)abstract
    • Research has consistently shown there is a negative correlation between age of onset (AO) of acquisition and ultimate attainment (UA) of either pronunciation or grammar in a second language (L2). A few studies have indeed reported nativelike behavior in some postpuberty learners with respect to either phonetics/phonology or morphosyntax, a result that has sometimes been taken as evidence against the critical period hypothesis (CPH). However, in the few studies that have employed a wide range of linguistic tests and tasks, adult learners have not exhibited nativelike L2 proficiency across the board of measures, which, according to some, suggests that the hypothesis still holds. The present study investigated the relationship between AO and UA and the incidence of nativelikeness when measures of phonetic and grammatical intuition are combined. An additional aim was to investigate whether children and adults develop the L2 through fundamentally different brain mechanisms-namely, whether children acquire the language (more) implicitly as an interdependent whole, whereas adults learn it (more) explicitly as independent parts of a whole.
  • Abrahamsson, Niclas (författare)
  • Andraspråksinlärning
  • 2009
  • Bok (övrigt vetenskapligt)abstract
    • Denna grundbok belyser fenomenet, ämnet och forskningsfältet andraspråksinlärning. Med utgångspunkt i 1960-talets brytning med behavioristisk inlärningspsykologi och kontrastiv språkanalys diskuteras de mest centrala frågeställningarna inom den därefter följande moderna, mentalistiskt orienterade andraspråksforskningen. I bokens tio kapitel presenteras de huvudsakliga empiriska upptäckterna och teorierna om andraspråkets utveckling och variation, dess kognition, processning och universella egenskaper, liksom inflödets, interaktionens och undervisningens roll, effekter av sociala och individuella skillnader samt modersmålets inverkan. Många exempel ges från studier av svenska som andraspråk. Boken avslutas med en termordlista med förklaringar till centrala begrepp inom fältet. Boken vänder sig främst till universitetsstuderande på grundnivå i ämnen som tvåspråkighet, svenska och nordiska språk samt till blivande och verksamma lärare i svenska som andraspråk och modersmålssvenska.
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