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Träfflista för sökning "WFRF:(Adamovic S) ;pers:(Adamovic Svetlana 1965)"

Search: WFRF:(Adamovic S) > Adamovic Svetlana 1965

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1.
  • Sarwar, Nadeem, et al. (author)
  • Interleukin-6 receptor pathways in coronary heart disease : a collaborative meta-analysis of 82 studies
  • 2012
  • In: The Lancet. - New York, NY, USA : Elsevier. - 0140-6736 .- 1474-547X. ; 379:9822, s. 1205-1213
  • Journal article (peer-reviewed)abstract
    • Background: Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. Methods: In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125 222 participants. We also compared the frequency of Asp358Ala in 51 441 patients with coronary heart disease and in 136 226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. Findings: The minor allele frequency of Asp358Ala was 39%. Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele >= 0.04 for each). By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34.3% (95% CI 30.4-38.2) and of interleukin 6 by 14.6% (10.7-18.4), and mean concentration of C-reactive protein was reduced by 7.5% (5.9-9.1) and of fibrinogen by 1.0% (0.7-1.3). For every copy of 358Ala inherited, risk of coronary heart disease was reduced by 3.4% (1.8-5.0). Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes. Interpretation: Large-scale human genetic and biomarker data are consistent with a causal association between IL6R-related pathways and coronary heart disease.
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2.
  • Adamovic, Svetlana, 1965, et al. (author)
  • Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32.
  • 2008
  • In: Tissue Antigens. - : Wiley. - 1399-0039 .- 0001-2815. ; 71:1, s. 27-34
  • Journal article (peer-reviewed)abstract
    • The previous genome-wide scan in Scandinavian families supported earlier evidence for linkage of a region on chromosome 5 (5q31–33) to coeliac disease. This study deals with further genetic mapping of an 18 cM region, spanning from marker GAh18A (131.87 Mb) to D5S640 (149.96 Mb). Linkage and association analyses were performed in a two-step approach. First, seven microsatellites were added. Strong evidence for linkage was obtained with a Zlr score of 3.96, Pnc = 4 × 10−5 at marker D5S436. The strongest association was with a haplotype consisting of the markers D5S2033 and D5S2490 (Pnc < 0.001). In the second step, we added 17 microsatellites and 69 single nucleotide polymorphisms (SNPs) to the analysis. These markers were located close to or within candidate genes across the region of approximately 7 Mb beneath the linkage peak marked by D5S2017 and D5S812. A substantial increase of the linkage signal with a maximum Zlr score of 4.6 at marker rs1972644 (Pnc = 2 × 10−6) was obtained and several SNPs showed association. Seven SNPs that individually showed the strongest association were genotyped in a second independent family sample set (225 trios). In the trio family sample as well as in the multiplex family sample, the strongest association was found with SNPs within the region flanked by the associated microsatellites D5S2033 and D5S2490 at 5q32.
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journal article (2)
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peer-reviewed (2)
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Adamovic, Svetla... (2)Undo refine
Karlsson, Magnus (1)
Nilsson, Staffan, 19 ... (1)
Salomaa, Veikko (1)
Gudjonsdottir, Audur ... (1)
Ascher, Henry, 1953 (1)
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Ek, Johan (1)
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Torinsson Naluai, Ås ... (1)
Amundsen, S. S. (1)
Lie, Benedicte Alexa ... (1)
Hellqvist, Åsa (1)
Wahlström, Jan, 1939 (1)
Davey Smith, George (1)
Nordestgaard, Borge ... (1)
Ouwehand, Willem H. (1)
Ohlsson, Claes, 1965 (1)
Goodall, Alison H (1)
Cambien, Francois (1)
Gillum, Richard F. (1)
Franks, Paul W. (1)
Clarke, Robert (1)
Ridker, Paul M. (1)
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Allin, Kristine H (1)
Boehnke, Michael (1)
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Qi, Lu (1)
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Saleheen, Danish (1)
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Rader, Daniel J. (1)
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Mellström, Dan, 1945 (1)
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Samani, Nilesh J. (1)
Wennberg, Patrik (1)
de Faire, Ulf (1)
Wilson, James F. (1)
Tivesten, Åsa, 1969 (1)
Ljunggren, Östen (1)
Jansson, John-Olov, ... (1)
Thomas, G. Neil (1)
Koenig, Wolfgang (1)
Harris, Tamara B (1)
Hofman, Albert (1)
Psaty, Bruce M (1)
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Medical and Health Sciences (2)

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