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Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study

Saevik, Ase Bjorvatn (author)
Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway,Univ Bergen, Norway; Univ Bergen, Norway
Ueland, Grethe (author)
Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway
Akerman, Anna-Karin (author)
Karolinska Institutet,Karolinska Inst, Sweden; Orebro Univ Hosp, Sweden
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Methlie, Paal (author)
Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway
Quinkler, Marcus (author)
Practice for Endocrinology and Nephrology, Endocrinology in Charlottenburg, Berlin, Germany,Endocrinol Charlottenburg, Germany
Jorgensen, Anders Palmstrom (author)
Department of Endocrinology, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway
Hoybye, Charlotte (author)
Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
Wahlberg, Jeanette (author)
Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
Nedrebo, Bjorn Gunnar (author)
Department of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway
Dahle, Anne Lise (author)
Department of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway
Carlsen, Siri (author)
Department of Endocrinology, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Norway
Tomkowicz, Aneta (author)
Department of Medicine, Sørlandet Hospital, Kristiansand, Norway,Sorlandet Hosp, Norway
Sollid, Stina Therese (author)
Department of Medicine, Drammen Hospital, Vestre Viken Health Trust, Drammen, Norway,Drammen Hosp, Norway
Nermoen, Ingrid (author)
Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
Gronning, Kaja (author)
Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway
Dahlqvist, Per (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden
Grimnes, Guri (author)
Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway; Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway,Univ Hosp North Norway, Norway; UiT Arctic Univ Norway, Norway
Skov, Jakob (author)
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden
Finnes, Trine (author)
Section of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway
Valland, Susanna F. (author)
Section of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway
Wahlberg, Jeanette, 1969- (author)
Linköping University, Linköping, Sweden
Holte, Synnove Emblem (author)
Department of Medicine, Sørlandet Hospital, Arendal, Norway,Sorlandet Hosp, Norway
Kampe, Olle (author)
Karolinska Institutet,Univ Bergen, Norway; Karolinska Inst, Sweden
Bensing, Sophie (author)
Karolinska Institutet,Karolinska Inst, Sweden
Husebye, Eystein Sverre (author)
Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden
Oksnes, Marianne (author)
Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden
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Department of Clinical Science, University of Bergen, Bergen, Norway; KG. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway Univ Bergen, Norway; Univ Bergen, Norway (creator_code:org_t)
Bioscientifica, 2023
2023
English.
In: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 189:4, s. 438-447
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addisons disease (AAD), but pathomechanisms are poorly understood.Design: Cross-sectional study.Methods: We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at >18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified for sex. Biomarker levels were correlated with the frequency of adrenal crises and quality of life (QoL) by AddiQoL-30. Finally, we investigated changes in biomarker levels following 250 mu g tetracosactide injection in patients without residual adrenocortical function (RAF) to explore glucocorticoid-independent effects of high ACTH.Results: Nineteen biomarkers significantly differed between patients with AAD and controls; all but 1 (ST1A1) were higher in AAD. Eight biomarkers were significantly higher in female patients compared with controls (IL6, MCP1, GAL9, SPON2, DR4, RAGE, TNFRSF9, and PGF), but none differed between male patients and controls. Levels of RAGE correlated with the frequency of adrenal crises (r = 0.415, P = .006) and AddiQoL-30 scores (r = -0.347, P = .028) but not after correction for multiple testing. PDL2 and leptin significantly declined 60 min after injection of ACTH in AAD without RAF (-0.15 normalized protein expression [NPX], P = .0001, and -0.25 NPX, P = .0003, respectively).Conclusions: We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Keyword

Autoimmunity
primary adrenal insufficiency
cardiovascular disease
proteomics
biomarkers

Publication and Content Type

ref (subject category)
art (subject category)

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