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- Sieberts, SK, et al.
(författare)
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Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
- 2016
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 12460-
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Tidskriftsartikel (refereegranskat)abstract
- Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the comparative evaluation of predictions developed by 73 research groups using the most comprehensive available data and covering a wide range of state-of-the-art modelling methodologies. Despite a significant genetic heritability estimate of treatment non-response trait (h2=0.18, P value=0.02), no significant genetic contribution to prediction accuracy is observed. Results formally confirm the expectations of the rheumatology community that SNP information does not significantly improve predictive performance relative to standard clinical traits, thereby justifying a refocusing of future efforts on collection of other data.
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| 5. |
- Farnsworth, Wesley R., et al.
(författare)
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Dynamic Holocene glacial history of St. Jonsfjorden, Svalbard
- 2017
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Ingår i: Boreas. - : Wiley. - 0300-9483. ; 46:3, s. 585-603
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Tidskriftsartikel (refereegranskat)abstract
- Evidence of a dynamic Holocene glacial history is preserved in the terrestrial and marine archives of St. Jonsfjorden, a small fjord-system on the west coast of Spitsbergen, Svalbard. High-resolution, remotely sensed imagery from marine and terrestrial environments was used to construct geomorphological maps that highlight an intricate glacial history of the entire fjord-system. The geomorphology and stratigraphy indicate an early Holocene local glacier advance constrained to the Lateglacial–early Holocene transition. Identification and 14C dating of the thermophilous bivalve mollusc Modiolus modiolus to 10.0±0.12 cal. ka BP suggest a rapid northward migration of the species shortly after deglaciation. Further evidence enhances the understanding of the onset and subsequent climax of the Neoglacial-Little Ice Age in inner St. Jonsfjorden. The present-day terminus of Osbornebreen, the dominating glacier system in St. Jonsfjorden, is located over 8.5 km up-fjord from its Neoglacial maximum extent. Cross-cutting relationships suggest subsequent advances of all the smaller glaciers in the area following the break-up of Osbornebreen. Glacial deposits, landforms and their cross-cutting relationships observed in both terrestrial and marine settings imply a complex and highly dynamic environment through the later part of the Holocene.
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| 6. |
- Farnsworth, Wesley R., et al.
(författare)
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Holocene glacial history of Svalbard : Status, perspectives and challenges
- 2020
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Ingår i: Earth-Science Reviews. - : Elsevier BV. - 0012-8252. ; 208
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Tidskriftsartikel (refereegranskat)abstract
- We synthesize the current understanding of glacier activity on Svalbard from the end of the Late Pleistocene (12,000 yrs. before present) to the end of the Little Ice Age (c. 1920 AD). Our glacier history is derived from the SVALHOLA database, the first compilation of Holocene geochronology for Svalbard and the surrounding waters, including over 1,800 radiocarbon, terrestrial cosmogenic nuclide and optically stimulated luminescence ages. Data have been categorized by geological setting, uniformly (re-)calibrated, quality assessed and ultimately used to constrain glacier fluctuations (deglaciation, ice free conditions, glacier re-advances and ice marginal positions). We advance existing knowledge by mapping the extent and distribution of ice-cover during the Holocene glacial maximum and the glacial minimum, as well as present retreat rates (and percentages) within Early Holocene fjord-systems. Throughout the Holocene, Svalbard glaciers have responded to a varying combination of climatic, environmental and dynamic driving factors which influence both the extent and behavior of ice margins. We discuss the complexities of glacier systems and their dynamics in response to changes in climate. This review provides a holistic state of the art of Holocene glaciers on Svalbard, suitable for orienting future works which address gaps in our current knowledge.
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| 8. |
- Schulz, A, et al.
(författare)
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Arctic ozone loss in threshold conditions: Match observations in 1997/1998 and 1998/1999
- 2001
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Ingår i: JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES. - : AMER GEOPHYSICAL UNION. - 0747-7309. ; 106:D7, s. 7495-7503
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Tidskriftsartikel (refereegranskat)abstract
- Chemical ozone loss rates inside the Arctic polar vortex were determined in early 1998 and early 1999 by using the Match technique based on coordinated ozonesonde measurements. These two winters provide the only opportunities in recent years to investigat
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