| 1. |
- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
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| 5. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Centeno, D, et al.
(författare)
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The nutritional supplement taurine activates p53-dependent and independent tumor suppressor mechanisms in various cellular models of ovarian cancer
- 2023
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Ingår i: bioRxiv : the preprint server for biology. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Loss of treatment-induced ovarian carcinoma (OC) growth suppression poses a major clinical challenge because it leads to disease recurrence. Therefore, new and well-tolerated approaches to maintain OC suppression after standard-of-care treatment are needed. We have profiled ascites as OC tumor microenvironments (TMs) to search for potential components that would exert growth suppression on OC cell cultures. Our investigations revealed that low levels of taurine, a non-proteogenic sulfonic amino acid, were present within OC ascites. Taurine supplementation, beyond levels found in ascites, induced growth suppression without causing cytotoxicity in multiple OC cell cultures, including patient-derived chemotherapy-resistant spheroid and organoid cultures. Suppression of proliferation by taurine was associated with the inhibition of glycolysis, mitochondrial function, and the activation of p21 and TIGAR, theTP53-dependent and independent tumor suppression regulatory pathways. Expression of p21 or TIGAR in various OC cells, in part, mimicked taurine-induced inhibition of OC cell proliferation. Our data support the potential therapeutic value of taurine supplementation in OC after chemotherapy.
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| 7. |
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| 8. |
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| 9. |
- Al-Rabiah, Abdulrahman A., et al.
(författare)
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Comparative Kinetic Analysis and Process Optimization for the Production of Dimethyl Ether via Methanol Dehydration over a γ-Alumina Catalyst
- 2022
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Ingår i: Chemical Engineering & Technology. - : Wiley. - 1521-4125 .- 0930-7516. ; 45:2, s. 319-328
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Tidskriftsartikel (refereegranskat)abstract
- Various kinetic models of methanol dehydration to dimethyl ether over a commercial γ-alumina catalyst were compared with a view to selecting the most appropriate model as a basis for process optimization. To achieve significant improvements in the conventional design, the Berčič-and-Levec kinetic model was employed and process intensification was applied to develop a more energy-efficient process, by enhancing the adiabatic reactor performance and maximizing the heat recovery from the highly exothermic reactor. The single-pass conversion of methanol was increased to 83 %, with an inlet temperature of 217 °C to the adiabatic reactor. Application of process intensification resulted in an improved flowsheet, which reduced the total energy requirements by 59.3 % and cut the CO2 emissions by 60.8 %.
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| 10. |
- Kebande, Victor R., 1985-, et al.
(författare)
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A blockchain-based multi-factor authentication model for a cloud-enabled internet of vehicles
- 2021
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Ingår i: Sensors. - : MDPI. - 1424-8220. ; 21:18
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Tidskriftsartikel (refereegranskat)abstract
- Continuous and emerging advances in Information and Communication Technology (ICT) have enabled Internet-of-Things (IoT)-to-Cloud applications to be induced by data pipelines and Edge Intelligence-based architectures. Advanced vehicular networks greatly benefit from these architectures due to the implicit functionalities that are focused on realizing the Internet of Vehicle (IoV) vision. However, IoV is susceptible to attacks, where adversaries can easily exploit existing vulnerabilities. Several attacks may succeed due to inadequate or ineffective authentication techniques. Hence, there is a timely need for hardening the authentication process through cutting-edge access control mechanisms. This paper proposes a Blockchain-based Multi-Factor authentication model that uses an embedded Digital Signature (MFBC_eDS) for vehicular clouds and Cloud-enabled IoV. Our proposed MFBC_eDS model consists of a scheme that integrates the Security Assertion Mark-up Language (SAML) to the Single Sign-On (SSO) capabilities for a connected edge to cloud ecosystem. MFBC_eDS draws an essential comparison with the baseline authentication scheme suggested by Karla and Sood. Based on the foundations of Karla and Sood’s scheme, an embedded Probabilistic Polynomial-Time Algorithm (ePPTA) and an additional Hash function for the Pi generated during Karla and Sood’s authentication were proposed and discussed. The preliminary analysis of the proposition shows that the approach is more suitable to counter major adversarial attacks in an IoV-centered environment based on the Dolev–Yao adversarial model while satisfying aspects of the Confidentiality, Integrity, and Availability (CIA) triad. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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