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Multiple Measures o...
Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966
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- Buxton, Jessica L. (author)
- Univ London Imperial Coll Sci Technol & Med, Dept Med, Sect Investigat Med, London, England
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- Das, Shikta (author)
- Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Ctr Environm & Hlth, MRC,Publ Hlth England,Dept Epidemiol & Biostat, London, England
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- Rodriguez, Alina (author)
- Mittuniversitetet,Avdelningen för psykologi,Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Ctr Environm & Hlth, MRC,Publ Hlth England,Dept Epidemiol & Biostat, London, England
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- Kaakinen, Marika (author)
- Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Ctr Environm & Hlth, MRC,Publ Hlth England,Dept Epidemiol & Biostat, London, England
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- Alves, Alexessander Couto (author)
- Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Ctr Environm & Hlth, MRC,Publ Hlth England,Dept Epidemiol & Biostat, London, England
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- Sebert, Sylvain (author)
- Univ Oulu, Inst Hlth Sci, Oulu, Finland
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- Millwood, Iona Y. (author)
- Univ Oxford, Clin Trial Serv Unit, Oxford, England
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- Laitinen, Jaana (author)
- Finnish Inst Occupat Hlth, Helsinki, Finland
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- O'Reilly, Paul F. (author)
- Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London, England
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- Jarvelin, Marjo-Riitta (author)
- Natl Inst Hlth & Welf, Dept Children & Young People & Families, Oulu, Finland
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- Blakemore, Alexandra I. F. (author)
- Univ London Imperial Coll Sci Technol & Med, Dept Med, Sect Investigat Med, London, England
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(creator_code:org_t)
- 2014-06-11
- 2014
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:6, s. Art. no. e99133-
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Abstract
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- Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Buxton, Jessica ...
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Das, Shikta
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Rodriguez, Alina
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Kaakinen, Marika
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Alves, Alexessan ...
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Sebert, Sylvain
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Millwood, Iona Y ...
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Laitinen, Jaana
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O'Reilly, Paul F ...
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Jarvelin, Marjo- ...
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Blakemore, Alexa ...
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