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Sökning: WFRF:(Aly M) > Kungliga Tekniska Högskolan

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1.
  • Wu, Chuanyan, et al. (författare)
  • Elevated circulating follistatin associates with an increased risk of type 2 diabetes
  • 2021
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12, s. 1-10
  • Tidskriftsartikel (refereegranskat)abstract
    • The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04-1.47, p < 0.05) during 19-year follow-up (n = 4060, Sweden); and 1.31 (CI: 1.09-1.58, p < 0.01) during 4-year follow-up (n = 883, Finland). High circulating follistatin associates with adipose tissue insulin resistance and non-alcoholic fatty liver disease (n = 210, Germany). In human adipocytes, follistatin dose-dependently increases free fatty acid release. In genome-wide association study (GWAS), variation in the glucokinase regulatory protein gene (GCKR) associates with plasma follistatin levels (n = 4239, Sweden; n = 885, UK, Italy and Sweden) and GCKR regulates follistatin secretion in hepatocytes in vitro. Our findings suggest that GCKR regulates follistatin secretion and that elevated circulating follistatin associates with an increased risk of T2D by inducing adipose tissue insulin resistance.
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2.
  • El-Mekawy, Mohamed Sobaih Aly, et al. (författare)
  • Integration of Legal Aspects in 3D Cadastral Systems
  • 2015
  • Ingår i: International Journal of E-Planning Research. - 2160-9918. ; 4:3, s. 47-71
  • Tidskriftsartikel (refereegranskat)abstract
    • This article continues a research on the feasibility of BIM for 3D cadastre in unified building models, presented in . It describes problems and solutions concerning interaction between BIM and the registration and visualisation of legal 3D property information. BIM and legal 3D property are two seemingly different domains, and there is a lack of BIM-3D property research in relation to technical and registration issues. The article therefore focuses on possibilities and difficulties of addressing legal interests (i.e. rights, restrictions and responsibilities) in land. A Swedish case study is used to describe the use of 3D property formation and registration in Sweden, and how it might be possible to achieve a more integrated, standard based registration of legal boundaries and physical buildings. The results emphasize how BIM and 3D property domains can interact to serve the needs for effective information handling by e.g. importing 3D cadastral boundaries into BIM as basis for decision-making or to use BIM as input in the 3D cadastral formation process.
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