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Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material
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Andersen, Flemming (author)
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Andersen, Kirsten H. (author)
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Bernois, Armand (author)
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Brault, Christophe (author)
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- Bruze, Magnus (author)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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Eudes, Herve (author)
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Gadras, Catherine (author)
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Signoret, Anne-Cecile J. (author)
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Mose, Kristian F. (author)
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Mueller, Boris P. (author)
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Toulemonde, Bernard (author)
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Andersen, Klaus Ejner (author)
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(creator_code:org_t)
- 2014-11-13
- 2015
- English.
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In: Contact Dermatitis. - : Wiley. - 0105-1873. ; 72:2, s. 75-83
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- BackgroundOak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens. ObjectivesTo compare the elicitation properties of two preparations of oak moss absolute: classic oak moss', the historically used preparation, and new oak moss', with reduced contents of the major allergens atranol and chloroatranol. Patients/materials/methodsThe two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects. ResultsIn both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations. ConclusionsNew oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- allergic contact dermatitis
- fragrances
- patch test
- risk assessment
Publication and Content Type
- art (subject category)
- ref (subject category)
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Andersen, Flemmi ...
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Andersen, Kirste ...
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Bernois, Armand
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Brault, Christop ...
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Bruze, Magnus
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Eudes, Herve
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Gadras, Catherin ...
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Signoret, Anne-C ...
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Mose, Kristian F ...
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Mueller, Boris P ...
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Toulemonde, Bern ...
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Andersen, Klaus ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
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Contact Dermatit ...
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Lund University