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- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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- Garrido-Urbani, Sarah, et al.
(författare)
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Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin
- 2016
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Ingår i: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 590:1, s. 3-12
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Tidskriftsartikel (refereegranskat)abstract
- Syntenin has crucial roles in cell adhesion, cell migration and synaptic transmission. Its closely linked postsynaptic density-95, discs large 1, zonula occludens-1 (PDZ) domains typically interact with C-terminal ligands. We profile syntenin PDZ1-2 through proteomic peptide phage display (ProP-PD) using a library that displays C-terminal regions of the human proteome. The protein recognizes a broad range of peptides, with a preference for hydrophobic motifs and has a tendency to recognize cryptic internal ligands. We validate the interaction with nectin-1 through orthogonal assays. The study demonstrates the power of ProP-PD as a complementary approach to uncover interactions of potential biological relevance.
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