↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Ashton NJ) ;pers:(Kloszewska I)"

Sökning: WFRF:(Ashton NJ) > Kloszewska I

Resultat 1-2 av 2

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Hye, A, et al. (författare) Plasma proteins predict conversion to dementia from prodromal disease 2014 Ingår i: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 10:6, s. 799-807 Tidskriftsartikel (refereegranskat)
2.	Kiddle, SJ, et al. (författare) Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes 2015 Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 5, s. e584- Tidskriftsartikel (refereegranskat)abstract There is great interest in blood-based markers of Alzheimer’s disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of pre-symptomatic AD. We also aimed to characterise confounding by genetics and the effect of genetics on blood proteins in general. Panel-based proteomics was performed using SOMAscan on plasma samples from TwinsUK subjects who are asymptomatic for AD, measuring the level of 1129 proteins. Protein levels were compared with 10-year change in CANTAB-paired associates learning (PAL; n=195), and regional brain volumes (n=34). Replication of proteins associated with regional brain volumes was performed in 254 individuals from the AddNeuroMed cohort. Across all the proteins measured, genetic factors were found to explain ~26% of the variability in blood protein levels on average. The plasma level of the mitogen-activated protein kinase (MAPK) MAPKAPK5 protein was found to positively associate with the 10-year change in CANTAB-PAL in both the individual and twin difference context. The plasma level of protein MAP2K4 was found to suggestively associate negatively (Q<0.1) with the volume of the left entorhinal cortex. Future studies will be needed to assess the specificity of MAPKAPK5 and MAP2K4 to eventual conversion to AD.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-2 av 2

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Westman, E (2); Simmons, A. (2); Soininen, H (2); Kloszewska, I (2)Ta bort avgränsningen; Lovestone, S (2); Mecocci, P (2); visa fler...; Vellas, B (2); Tsolaki, M (2); Ashton, NJ (2); Bazenet, C (2); Sattlecker, M (2); Nelson, S. (1); Hye, A (1); Zheng, W. (1); Breen, G (1); Ward, M. (1); Curtis, C (1); Richardson, J (1); Dobson, RJB (1); Williams, SCR (1); Gauthier, S (1); Spector, TD (1); Leung, R. (1); Xu, X. (1); Dobson, R. (1); Steves, CJ (1); Mehta, M. (1); Zucht, HD (1); Newhouse, S (1); Lunnon, K (1); Keohane, A (1); Riddoch-Contreras, J (1); Baird, AL (1); Lupton, M (1); Pike, I (1); Pepin, D (1); Tunnicliffe, A (1); Kiddle, SJ (1); Killick, R (1); Adnan, J (1); visa färre...

Lärosäte: Karolinska Institutet (2)

Språk: Engelska (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy