Sökning: WFRF:(Axelsson Jan 1966 )
> (2020-2022)
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Rectal cancer :
Rectal cancer : a methodological approach to matching PET/MRI to histopathology
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- Rutegård, Miriam (författare)
- Umeå universitet,Diagnostisk radiologi
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- Båtsman, Malin (författare)
- Umeå universitet,Patologi
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- Blomqvist, Lennart (författare)
- Karolinska Institutet,Umeå universitet,Diagnostisk radiologi,Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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- Rutegård, Martin, 1982- (författare)
- Umeå universitet,Kirurgi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Axelsson, Jan, 1966- (författare)
- Umeå universitet,Radiofysik
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- Ljuslinder, Ingrid, 1968- (författare)
- Umeå universitet,Onkologi
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- Rutegård, Jörgen, 1948- (författare)
- Umeå universitet,Onkologi
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- Palmqvist, Richard (författare)
- Umeå universitet,Patologi
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- Brännström, Fredrik (författare)
- Umeå universitet,Kirurgi
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- Brynolfsson, Patrik (författare)
- Umeå universitet,Radiofysik
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- Riklund, Katrine, MD, PhD, Professor, 1963- (författare)
- Umeå universitet,Diagnostisk radiologi
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(creator_code:org_t)
- 2020-10-31
- 2020
- Engelska.
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Ingår i: Cancer Imaging. - : BioMed Central (BMC). - 1740-5025 .- 1470-7330. ; 20:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://cancerimagin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Purpose: To enable the evaluation of locoregional disease in the on-going RECTOPET (REctal Cancer Trial on PET/MRI/CT) study; a methodology to match mesorectal imaging findings to histopathology is presented, along with initial observations.Methods: FDG-PET/MRI examinations were performed in twenty-four consecutively included patients with rectal adenocarcinoma. In nine patients, of whom five received neoadjuvant treatment, a postoperative MRI of the surgical specimen was performed. The pathological cut-out was performed according to clinical routine with the addition of photo documentation of each slice of the surgical specimen, meticulously marking the location, size, and type of pathology of each mesorectal finding. This allowed matching individual nodal structures from preoperative MRI, via the specimen MRI, to histopathology.Results: Preoperative MRI identified 197 mesorectal nodal structures, of which 92 (47%) could be anatomically matched to histopathology. Of the matched nodal structures identified in both MRI and histopathology, 25% were found to be malignant. These malignant structures consisted of lymph nodes (43%), tumour deposits (48%), and extramural venous invasion (9%). One hundred eleven nodal structures (55%) could not be matched anatomically. Of these, 97 (87%) were benign lymph nodes, and 14 (13%) were malignant nodal structures. Five were malignant lymph nodes, and nine were tumour deposits, all of which had a short axis diameter < 5 mm.Conclusions: We designed a method able to anatomically match and study the characteristics of individual mesorectal nodal structures, enabling further research on the impact of each imaging modality. Initial observations suggest that small malignant nodal structures assessed as lymph nodes in MRI often comprise other forms of mesorectal tumour spread.Trial registration: Clinical Trials Identifier: NCT03846882.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Rectal neoplasms
- EMVI
- Staging
- Lymph nodes
- Tumour deposits
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Rutegård, Miriam
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Båtsman, Malin
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Blomqvist, Lenna ...
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Rutegård, Martin ...
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Axelsson, Jan, 1 ...
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Ljuslinder, Ingr ...
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Rutegård, Jörgen ...
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Palmqvist, Richa ...
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Brännström, Fred ...
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Brynolfsson, Pat ...
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Riklund, Katrine ...
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- MEDICIN OCH HÄLSOVETENSKAP
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- Artiklar i publikationen
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Cancer Imaging
- Av lärosätet
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Umeå universitet
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Karolinska Institutet