| 1. |
- Kirkeby, A., et al.
(författare)
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Strategies for bringing stem cell-derived dopamine neurons to the clinic : A European approach (STEM-PD)
- 2017
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Ingår i: Functional Neural Transplantation IV Translation to Clinical Application, Part A. - : Elsevier. - 0079-6123. - 9780128117385 ; 230, s. 165-190
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Bokkapitel (refereegranskat)abstract
- The treatment of Parkinson's disease (PD) has for over 50 years relied on dopaminergic therapies that are highly effective especially in the early years of the condition, but ultimately are limited by the development of side effects that relate to the nonphysiological stimulation of dopamine receptors including in nonstriatal areas. Targeted regenerative therapies designed to restore specifically the lost dopaminergic innervation of the striatum would therefore represent a major advance in treating PD. Transplantation of human fetal ventral midbrain tissue to the striatum of PD patients has provided proof-of-principle that such an approach can provide long-term clinical benefits with a reduced dependency on any oral dopaminergic agents. However, fetal tissue is associated with several ethical and logistical problems and therefore does not represent a realistic route to the clinical treatment of PD in the future. As a result, alternative cell sources have been explored and the methods for producing authentic midbrain dopaminergic neurons from pluripotent cells have now advanced to a stage which makes it possible to efficiently and reproducibly produce DA progenitors at a much higher purity than can be obtained from human fetal tissue. A stem cell-based therapy for PD therefore has the potential to circumvent many of the problems currently associated with fetal tissue grafting. Here, we describe the challenges faced and the strategies that have been pursued in our European effort to bring a human embryonic stem cell (hESC)-derived dopamine cell product to clinical trial for PD.
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| 2. |
- Dakers, A, et al.
(författare)
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Ecosystem Services
- 2002
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Ingår i: Understanding and Solving Environmental Problems in the 21st Century. ; , s. 127-138
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Barker, Roger A., et al.
(författare)
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Restorative cell and gene therapies for Parkinson's disease
- 2023
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Ingår i: Precision Medicine in Neurodegenerative Disorders, Part II. - 2212-4152 .- 0072-9752. - 9780323855556 ; 193, s. 211-226
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Bokkapitel (refereegranskat)abstract
- One of the core pathological features of Parkinson's disease (PD) is the loss of the dopaminergic nigrostriatal pathway which lies at the heart of many of the motor features of this condition as well as some of the cognitive problems. The importance of this pathological event is evident through the clinical benefits that are seen when patients with PD are treated with dopaminergic agents, at least in early-stage disease. However, these agents create problems of their own through stimulation of more intact dopaminergic networks within the central nervous system causing major neuropsychiatric problems including dopamine dysregulation. In addition, over time the nonphysiological stimulation of striatal dopamine receptors by L-dopa containing drugs leads to the genesis of L-dopa-induced dyskinesias that can become very disabling in many cases. As such, there has been much interest in trying to better reconstitute the dopaminergic nigrostriatal pathway using either factors to regrow it, cells to replace it, or gene therapies to restore dopamine transmission in the striatum. In this chapter, we lay out the rationale, history and current status of these different therapies as well as highlighting where the field is heading and what new interventions might come to clinic in the coming years.
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| 4. |
- Foka, Anna, 1981-, et al.
(författare)
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Heritage metadata : a digital periegesis
- 2022
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Ingår i: Information and knowledge organisation in digital humanities. - Abingdon : Routledge. - 9780367675516 - 9780367675684 - 9781003131816 ; , s. 227-242
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Bokkapitel (refereegranskat)abstract
- Over the past decades the extraordinary growth of new technologies has made it possible to extract data from literary texts and analyse them using digital tools. This chapter focuses on the process of creating an enriched digital edition of Pausanias's Periegesis Hellados or Description of Greece. The purpose of this research is twofold: to identify 'heritage data' in Pausanias and to describe the technical and epistemological parameters of their aggregation and organisation. In answering the essentially digital humanities research question "how Pausanias's literary heritage information can be best organised and connected to the archaeological record on the ground", the Digital Periegesis project is charting and analysing the relevant digital tools and methods by which extensive semantic annotation and Linked Open Data (LOD) can facilitate the organisation of heritage information in Pausanias's text and its connection to actual archaeological finds. This chapter discusses the potential application of Geographic Information Science (GISc) and Geographic Information System (GIS) for such complex pre-cartesian narrative analysis. Finally, it emphasises the importance of building geo-spatially enriched digital editions collaboratively, involving discipline specialist researchers and information organisation experts, with the aim of interpreting histories of "place".
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| 5. |
- Foka, Anna, et al.
(författare)
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Mapping Ancient Heritage Narratives with Digital Tools
- 2021
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Ingår i: Virtual Heritage: A Guide. - London : Ubiquity Press. - 9781914481000 - 9781914481024 - 9781914481031 - 9781914481017 ; , s. 55-65
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Bokkapitel (refereegranskat)abstract
- How does 'digital' apply to ancient pasts? Digital methods, especially methods relating to identifying, visualizing, and analysing spatial data, have become increasingly important within the fields of classical literature, archaeology, and heritage. On the one hand, literary narratives offer potentially different ways of representing space and place than the usual cartographic maps to which we have become accustomed. On the other hand, by virtue of being able to locate cultural artefacts in space – where they were found, through whose hands they have passed, where they reside now, where they were produced and circulated– it becomes possible to construct biographies or even itineraries of objects that offer richer ways of understanding their use and agency. Unique in all classical literature, Pausanias’s second-century CE Periegesis Hellados presents an example of both types of spatial representation – a narrative that describes places of interest in the Greek landscape as well as the notable objects found there. This chapter discusses some of the ways in which Pausanias’s narrative of Greek heritage is good to consider when attempting to use digital methods for analysing the entanglements of place, people, ando bjects in a textual geography.
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| 6. |
- Karis, Per Ola, et al.
(författare)
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Arctotideae
- 2009
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Ingår i: Systematics, Evolution and Biogeography of Compositae. - Vienna : International Association for Plant Taxonomy. - 9783950175431 ; , s. 285-310
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Saltzman, Katarina, 1966, et al.
(författare)
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Gardeners’ perspectives and practices in relation to plants in motion
- 2021
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Ingår i: Routledge Handbook of Biosecurity and Invasive Species. - Abingdon, Oxon ; New York, NY : Routledge, 2021. : Routledge. - 9780815354895 ; , s. 226-239
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Bokkapitel (refereegranskat)abstract
- The establishment of introduced species in new environments is today widely acknowledged as a potential threat to biodiversity, and many plants that are known to be invasive have obviously spread from gardens. Thus, in the context of biosecurity, we need to consider how contemporary gardeners think about which plants and animals are welcome in their gardens. In this chapter we look at vegetation in motion from a cultural and social point of view, with a particular focus on some of many different ways in which people are involved in spreading of plants, both desired and undesired ones. We do this by investigating everyday practices of gardeners in Sweden, and not least the common habit of sharing plants, in order to highlight the social and cultural aspects of the spread of species. Among the gardeners in this study it is obvious that the dynamics and vitality of plants is often regarded as an asset, but also sometimes as problem, when plants simply grow too much. Understandings of the relationship between gardens and surrounding environments, as well as between nature and culture, have changed over time, and are continuously changing. As plants have the ability to multiply and spread in various ways, both on their own and with the help of humans, there is a need to acknowledge the role of human as well as non-human agencies in order to understand the complexity of these interactions. Inspired by Tim Ingold we find it useful to think about both gardeners and plants as ‘biosocial becomings’. In order to address the threat posed by invasive species, we propose that it is important to improve our understanding of what happens in everyday biosocial encounters between people, plants and other species.
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| 8. |
- Vörösmarty, C J, et al.
(författare)
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Fresh Water
- 2005
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Ingår i: Ecosystems and human well-being: Current state and trends. - : Island Press, Washington.
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Bokkapitel (refereegranskat)
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