Sökning: WFRF:(Baron John A)
> Högskolan Dalarna >
The impact and caus...
The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
-
- Michaëlsson, Madeleine, 1968- (författare)
- Högskolan Dalarna,Pedagogiskt arbete,Dalarna Univ, Dept Educ, Falun, Sweden.
-
- Yuan, Shuai (författare)
- Karolinska Institutet
-
- Melhus, Håkan (författare)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden
-
visa fler...
-
- Baron, John A. (författare)
- Uppsala universitet,Medicinsk epidemiologi,Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27515 USA.;Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA.,Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA; Department of Surgical Sciences, Unit of Medical Epidemiology, Uppsala University, Uppsala, Sweden
-
- Byberg, Liisa (författare)
- Uppsala universitet,Medicinsk epidemiologi,Department of Surgical Sciences, Unit of Medical Epidemiology, Uppsala University, Uppsala, Sweden
-
- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.,Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Sciences, Unit of Medical Epidemiology, Uppsala University, Uppsala, Sweden
-
- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Medicinsk epidemiologi,Department of Surgical Sciences, Unit of Medical Epidemiology, Uppsala University, Uppsala, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2022-04-11
- 2022
- Engelska.
-
Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 20:1
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://du.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Previous studies have reported associations between attention-deficit/hyperactivity disorder (ADHD) and lower socioeconomic status and intelligence. We aimed to evaluate the causal directions and strengths for these associations by use of a bi-directional two-sample Mendelian randomization (MR) design. Methods We used summary-level data from the largest available genome-wide association studies (GWAS) to identify genetic instruments for ADHD, intelligence, and markers of socioeconomic status including the Townsend deprivation index, household income, and educational attainment. Effect estimates from individual genetic variants were combined using inverse-variance weighted regression. Results A genetically predicted one standard deviation (SD) increment in the Townsend deprivation index conferred an odds ratio (OR) of 5.29 (95% confidence interval (CI) 1.89-14.76) for an ADHD diagnosis (p<0.001). A genetically predicted one SD higher education level conferred an OR of 0.30 (95% CI 0.25-0.37) (p<0.001), and a genetically predicted one SD higher family income provided an OR of 0.35 (95% CI 0.25-0.49; p<0.001). The associations remained after adjustment for intelligence whereas the lower odds of an ADHD diagnosis with higher intelligence did not persist after adjustment for liability to greater educational attainment (adjusted OR 1.03, 95% CI 0.68-1.56; p=0.87). The MR analysis of the effect of ADHD on socioeconomic markers found that genetic liability to ADHD was statistically associated with each of them (p<0.001) but not intelligence. However, the average change in the socioeconomic markers per doubling of the prevalence of ADHD corresponded only to 0.05-0.06 SD changes. Conclusions Our results indicate that an ADHD diagnosis may be a direct and strong intelligence-independent consequence of socioeconomic related factors, whereas ADHD appears to lead only to modestly lowered socioeconomic status. Low intelligence seems not to be a major independent cause or consequence of ADHD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Utbildningsvetenskap -- Lärande (hsv//swe)
- SOCIAL SCIENCES -- Educational Sciences -- Learning (hsv//eng)
Nyckelord
- Attention-deficit
- hyperactivity disorder
- ADHD
- Socioeconomic status
- Education
- Intelligence
- Income
- Townsend deprivation index
- Mendelian randomization
- Gene
- GWAS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas