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Cellular receptor i...
Cellular receptor interactions of C-cluster human group A coxsackieviruses.
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- Newcombe, Nicole G (author)
- University of Newcastle
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- Andersson, Per (author)
- Högskolan i Kalmar,Naturvetenskapliga institutionen
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- Johansson, E Susanne (author)
- University of Newcastle
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- Au, Gough G (author)
- University of Newcastle
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- Lindberg, A. Michael (author)
- Högskolan i Kalmar,Naturvetenskapliga institutionen
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- Barry, Richard D (author)
- University of Newcastle
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- Shafren, Darren R (author)
- University of Newcastle
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(creator_code:org_t)
- London : Society for General Microbiology, 2003
- 2003
- English.
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In: Journal of General Virology. - London : Society for General Microbiology. - 0022-1317 .- 1465-2099. ; 84:Pt 11, s. 3041-3050
- Related links:
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http://vir.sgmjourna...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The cellular receptor complex of coxsackievirus A21 (CVA21), a C-cluster human enterovirus, is formed by the subtle interaction of individual cellular receptors, decay accelerating factor (DAF) and intercellular adhesion molecule-1 (ICAM-1). In this receptor complex, DAF functions in the membrane sequestration of the virus, while the role of ICAM-1 is as the functional cellular internalization receptor. However, despite the elucidation of the CVA21-cell receptor interactions, there have been few definite investigations into cellular receptor usage of other coxsackie A viruses (CVAs) belonging to the C-cluster. In the present study, radiolabelled virus-binding assays demonstrated that CVA13, -15, -18 and -20, a subset of the human enterovirus C-cluster, bind directly to surface-expressed ICAM-1, but not to surface-expressed DAF. Furthermore, lytic infection of ICAM-1-expressing rhabdomyosarcoma (RD) cells by this C-cluster subset of viruses was inhibited by specific ICAM-1 monoclonal antibody blockade, except for that of CVA20. Despite possessing ICAM-1-binding capabilities, CVA20 employed an as yet unidentified internalization receptor for cell entry and subsequent productive lytic infection of ICAM-1-negative RD cells. In a further example of C-cluster cellular receptor heterogeneity, CVA13 exhibited significant binding to the surface of CHO cells expressing neither DAF nor ICAM-1. Despite a common receptor usage of ICAM-1 by this subset of C-cluster CVAs, the amino acid residues postulated to represent the ICAM-1-receptor footprint were not conserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Virology
- Virologi
- Virologi
- Virology
Publication and Content Type
- ref (subject category)
- art (subject category)
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