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Cardiac MRI Endpoin...
Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials : JACC Scientific Expert Panel
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- Ibanez, Borja (author)
- Centro Nacional de Investigaciones Cardiovasculares Carlos III,Hospital Fundación Jiménez Díaz
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- Aletras, Anthony H. (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups,Aristotle University of Thessaloniki
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- Arai, Andrew E. (author)
- National Heart Lung and Blood Institute
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- Arheden, Hakan (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Cardiac MR Group,Lund University Research Groups
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- Bax, Jeroen (author)
- Leiden University Medical Centre
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- Berry, Colin (author)
- University of Glasgow
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- Bucciarelli-Ducci, Chiara (author)
- University of Bristol
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- Croisille, Pierre (author)
- University of Lyon
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- Dall'Armellina, Erica (author)
- University of Leeds
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- Dharmakumar, Rohan (author)
- University of California, Los Angeles
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- Eitel, Ingo (author)
- German Centre for Cardiovascular Research
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- Fernández-Jiménez, Rodrigo (author)
- Centro Nacional de Investigaciones Cardiovasculares Carlos III,Icahn School of Medicine at Mount Sinai
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- Friedrich, Matthias G. (author)
- Heidelberg University,McGill University
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- García-Dorado, David (author)
- Autonomous University of Barcelona
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- Hausenloy, Derek J. (author)
- University College London,National University of Singapore
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- Kim, Raymond J. (author)
- Duke University Medical Center
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- Kozerke, Sebastian (author)
- ETH Zürich
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- Kramer, Christopher M. (author)
- University of Virginia Health System
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- Salerno, Michael (author)
- University of Virginia Health System
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- Sánchez-González, Javier (author)
- Philips Healthcare Netherlands
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- Sanz, Javier (author)
- Icahn School of Medicine at Mount Sinai,Centro Nacional de Investigaciones Cardiovasculares Carlos III
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- Fuster, Valentin (author)
- Centro Nacional de Investigaciones Cardiovasculares Carlos III,Icahn School of Medicine at Mount Sinai
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English 19 s.
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In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 74:2, s. 238-256
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- area at risk
- clinical trial
- edema
- endpoint
- infarct size
- magnetic resonance imaging
- myocardial infarction
- STEMI
Publication and Content Type
- for (subject category)
- ref (subject category)
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Ibanez, Borja
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Aletras, Anthony ...
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Arai, Andrew E.
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Arheden, Hakan
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Bax, Jeroen
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Berry, Colin
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Bucciarelli-Ducc ...
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Croisille, Pierr ...
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Dall'Armellina, ...
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Dharmakumar, Roh ...
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Eitel, Ingo
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Fernández-Jiméne ...
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Friedrich, Matth ...
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García-Dorado, D ...
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Hausenloy, Derek ...
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Kim, Raymond J.
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Kozerke, Sebasti ...
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Kramer, Christop ...
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Salerno, Michael
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Sánchez-González ...
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Sanz, Javier
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Fuster, Valentin
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