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- 2019
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Tidskriftsartikel (refereegranskat)
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- Rutkowski, Michael J., et al.
(författare)
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LYMAN CONTINUUM ESCAPE FRACTION OF STAR-FORMING DWARF GALAXIES AT z similar to 1
- 2016
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 819:1
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Tidskriftsartikel (refereegranskat)abstract
- To date, no direct detection of Lyman continuum emission has been measured for intermediate-redshift (z similar to 1) star-forming galaxies. We combine Hubble Space Telescope grism spectroscopy with GALEX UV and ground-based optical imaging to extend the search for escaping Lyman continuum to a large (similar to 600) sample of z similar to 1 low-mass (log((M) over bar) similar or equal to 9.3M(circle dot)), moderately star-forming ((Psi) over bar less than or similar to 10M(circle dot) yr(-1)) galaxies selected initially on H alpha emission. The characteristic escape fraction of LyC from star-forming galaxies (SFGs) that populate this parameter space remains weakly constrained by previous surveys, but these faint (sub-L-star) SFGs are assumed to play a significant role in the reionization of neutral hydrogen in the intergalactic medium (IGM) at high redshift z > 6. We do not make an unambiguous detection of escaping LyC radiation from this z similar to 1 sample, individual non-detections to constrain the absolute Lyman continuum escape fraction, f(esc) < 2.1% (3 sigma). We measure an upper limit of f(esc) < 9.6% from a sample of SFGs selected on high H alpha equivalent width (EW > 200 angstrom), which are thought to be close analogs of high redshift sources of reionization. For reference, we also present an emissivity-weighted escape fraction that is useful for measuring the general contribution SFGs to the ionizing UV background. In the discussion, we consider the implications of these intermediate redshift constraints for the reionization of hydrogen in the IGM at high (z > 6) redshift. If we assume our z similar to 1 SFGs, for which we measure this emissivity-weighted f(esc), are analogs to the high redshift sources of reionization, we find it is difficult to reconcile reionization by faint (MUV less than or similar to -13) SFGs with a low escape fraction (f(esc) < 3%), with constraints from independent high redshift observations. If f(esc) evolves with redshift, reionization by SFGs may be consistent with observations from Planck.
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- Schuette, Moritz, et al.
(författare)
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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I-IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling 44,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.
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