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| 2. |
- Bengtsson, Felix, et al.
(författare)
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Dataset: Alkali Ion diffusion and structure of chemically strengthened TiO2 doped soda-lime silicate glass
- 2022
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Annan publikationabstract
- Diffusion kinetics and structural properties of chemically strengthened titania-doped soda-lime silicate glasses were studied by depth-resolved X-ray photoelectron spectroscopy, Raman spectroscopy and spectrophotometry.Chemical strengthening (CS) is frequently used to strengthen thin glasses. CS of glass is based on ion exchange of larger ions from a molten salt into glass. Both the ion and counter ion are conventionally monovalent alkali ions.Diffusion kinetics and structural properties of chemically strengthened titania-doped (TiO2) soda-lime silicate (SLS) glasses were studied by depth-resolved X-ray photoelectron spectroscopy, Raman spectroscopy and spectrophotometry. The glasses were ion exchanged, whereby Na+ in the glass was replaced by K+ in a molten salt bath, at four different treatment temperatures between 350 and 500 °C.The following samples were prepared and analyzed by X-ray Photoelectron Spectroscopy (XPS): (1) SLS, (2) 4.7% TiO2, and (3) 9.9% TiO2. The ion exchange procedure was performed for 5 h at four different temperatures below Tg (350, 400, 450 and 500 °C). Before XPS measurements, the samples were wet-etched using hydrofluoric (HF) acid to produce samples with six different etching depths.The Raman scattered light was detected in the backscattering configuration employing linear polarization and 2400 lines/mm grating, and a 100x objective lens. Depth profile spectra were collected at six different depths of 0, 10, 20, 30, 40, and 50 µm for each glass sample, employing 12 scans with a 10 s exposure time for each scan.Spectrophotometric measurements were conducted before and after K+/Na+ ion-exchange treatmeatment for 5 h at 500 °C, collected between 300 and 2500 nm.
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| 3. |
- Bengtsson, Lars, et al.
(författare)
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Towards a holistic user innovation policy
- 2020
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This paper aims to synthesize previous user innovation policy proposals into an adapted systems of innovation framework, on which a holistic user innovation policy for the household sector can be based. We identify and review policy proposals made by user innovation researchers and categorize them according to ten key activities in the systems of innovation framework. In the review of 22 publications with policy proposals on user innovation, we find that the publications lack an integrating innovation policy framework. Most of them limit their policy proposals to a few policy activities, i.e., the innovation policy proposals are partial and mono-causal. In contrast to the linear view of the innovation process, user innovation researchers predominantly adopt an institutional view of the innovation process. Based on a systems of innovation framework, we propose a holistic innovation policy framework adapted to user innovation in the household sector. It is centered on ten key activities and policy instruments related to them. Our proposals effectively provide policy development support to policy researchers, policymakers, and politicians stressing the multicausal and non-linear features of the user innovation process.
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| 4. |
- Bengtsson, Lars, et al.
(författare)
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Vattenomsättning i några svenska städer
- 2003
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Annan publikation (refereegranskat)abstract
- The inner and outer water balance in six Swedish cities has been studied.Direct stormwater contribution to the combined system has beendetermined, as has drainage of soil and groundwater to this system.Diffuse runoff not being in the sewerage or stormwater systems has alsobeen determined. The leakage into the sewerage system is almost thesame in all cities. The diffuse runoff depends on climatic factors.
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| 5. |
- Bolin, Karin, 1982-, et al.
(författare)
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Variants in BANK1 are associated with lupus nephritis
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Background: Lupus nephritis (LN) is a cause of significant morbidity in SLE. While the genetic background to SLE has been well characterized, less is known about genes predisposing to LN.Methods: The study consisted of 2886 SLE patients, including 947 (33%) with LN. The discovery cohort (Sweden, n=1091) and replication cohort 1 (US, n=962) were genotyped on the Immunochip and replication cohort 2 (Norway/Denmark, n=833) on a custom array chip. Allele frequencies were compared between patients with LN, proliferative nephritis, end-stage renal disease and LN negative patients. SNPs with p-value <0.001 in the discovery cohort were analyzed in replication cohort 1. Ten SNPs associated with LN in the discovery cohort (p<0.0002) were genotyped in replication cohort 2. DNA methylation data were available for 180 LN patients from the discovery cohort.Results: In the discovery cohort, six gene loci were associated with LN (p<1x10-4, NFKBIA, CACNA1S, ITGA1, BANK1, OR2Y and PHCA). SNPs in BANK1 showed the strongest association with LN in replication cohort 1 (p=9.5x10-4), with a tendency for an association in replication cohort 2 (p=0.052). In a meta-analysis of all three cohorts the association between LN and BANK1 rs4699259, was strengthened (p=1.7x10‑7). There were no associations to proliferative nephritis or ESRD in the meta-analysis. Methylation quantitative trait loci (MeQTL) effects between a CpG site and several SNPs in BANK1 were identified.Conclusion: Genetic variations in BANK1 are associated with LN. There is evidence for genetic regulation of DNA methylation within the BANK1 locus, however, the exact role of BANK1 in LN pathogenesis remains to be elucidated.
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| 6. |
- Czemiel Berndtsson, Justyna, et al.
(författare)
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Stadens inverkan på vattenmiljön i avrinningsområden
- 2006
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Annan publikation (refereegranskat)abstract
- The influence of the city on the water environment on river basin scale is discussed with mainly the Höje River as an example. The city significantly influence the phosphorous and heavy metal conditions if the city is larger than about 100 000 people in an agricultural river basin smaller than 300 km2.
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| 7. |
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| 8. |
- Reid, Sarah, et al.
(författare)
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From genetic predisposition to clinical outcome in systemic lupus erythematosus : construction and validation of sub-phenotype-specific genetic risk scores
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- ObjectiveThis study aimed to link known genetic risk factors for systemic lupus erythematosus (SLE) with specific clinical manifestations of the disease, in both a large biobank population and in a clinical cohort of patients with SLE.MethodsScandinavian patients with SLE (n=1487) who fulfilled ≥4 ACR-82/ACR-97/SLICC-2012 classification criteria, were genotyped using the Immunochip or Global Screening array (Illumina). Clinical data was collected from medical records. Summary statistics for 57 established SLE risk SNPs (p<5×10-8 in the European population) with a validated cumulative effect on disease severity in SLE, was retrieved for 30 FinnGen datasets covering manifestations relevant for SLE. Mendelian randomization (MR) analysis was performed using the inverse variance weighed method. Nine datasets were selected for construction of standardized genetic risk scores (GRSs), which were validated in the clinical cohort using gender- and disease duration-adjusted logistic regression.ResultsIn the FinnGen biobank, the cumulative effect of the 57 SLE risk SNPs was associated with an increased risk of rosacea, OR 1.09 (1.03–1.16), polyarthropathies, OR 1.10 (1.06–1.14), pleural effusions, OR 1.09 (1.04–1.14)) and hemolytic anemia, OR 1.32 (1.10–1.58). In the clinical cohort, the GRSs generated from the FinnGen datasets were associated with their corresponding manifestation for arthritis, OR 1.15 (1.02– 1.31), renal disorder, OR 1.15 (1.04–1.29), neurologic disorder, OR 1.24 (1.04–1.47), hematologic disorder, OR 1.12 (1.00–1.24), and immunologic disorder, OR 1.37 (1.22–1.56).ConclusionBy considering associations of SLE risk SNPs with SLE-like manifestations in the FinnGen biobank, construction and validation of GRSs for five of the eleven ACR-82 criteria was possible. The findings may facilitate personalized risk prediction and targeted intervention strategies for patients with SLE.
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| 9. |
- Ribeiro, Barbara, et al.
(författare)
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Considering the dilemma of societal alignment: A response
- 2020
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The publication of our article “Introducing the dilemma of societal alignment for inclusive and responsible research and innovation” (Ribeiro et al., 2018) was accompanied by three commentaries (Guston, 2018; Nordmann, 2018; and Kuzma and Roberts, 2018). In the original article, we invoked Collingridge’s dilemma of the social control of technology to introduce a complementary dilemma of “societal alignment” in the governance of science, technology and innovation. Thoughtful and challenging critiques were presented in the three commentaries. In this paper, as completed in June 2019, we respond to those critiques and, in so doing, seek to further clarify and extend our arguments.
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| 10. |
- Rodling Wahlström, Marie, 1960-, et al.
(författare)
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Prostacyclin modulates the systemic inflammatory response in traumatic brain injury : a randomised clinical study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Purpose: Systemic inflammatory response is common in patients with severe traumatic brain injury (TBI), and may contribute to a less favourable outcome. The aim was to evaluate the effect of prostacyclin on systemic inflammation.Methods: This study is part of a prospective, randomised, clinical trial on the effect of prostacyclin (epoprostenol, Flolan®) in patients with severe TBI. Epoprostenol/placebo was given during 72 hours and then de-escalated. Interleukin-6, interleukin-8, soluble intracellular adhesion molecules-1 (sICAM-1) and C-reactive protein (CRP) were sampled daily.Results: 46 patients were included and randomised to 23 of each group (epoprostenol/placebo). Interleukin-6 was statistically lower within 96 hours (p = 0.04), and CRP within 96 and 120 hours (p = 0.04 and p = 0.008 respectively) after trauma in the epoprostenol group compared to the placebo group. No significant differences were detected between the groups in the levels of interleukin-8 and sICAM-1 or in outcome.Conclusions: Administration of the prostacyclin analogue epoprostenol, compared to placebo significantly decreased interleukin-6 and CRP levels in patients with severe TBI. The beneficial effect of this decrease is further to investigate.
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