| 1. |
- He, L., et al.
(author)
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Biomass valorization toward sustainable asphalt pavements : Progress and prospects
- 2023
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In: Waste Management. - : Elsevier. - 0956-053X .- 1879-2456. ; 165, s. 159-178
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Journal article (peer-reviewed)abstract
- To cope with the global climate crisis and assist in achieving the carbon neutrality, the use of biomass materials to fully or partially replace petroleum-based products and unrenewable resources is expected to become a widespread solution. Based on the analysis of the existing literature, this paper firstly classified biomass materials with potential application prospects in pavement engineering according to their application and summarized their respective preparation methods and characteristics. The pavement performance of asphalt mixtures with biomass materials was analyzed and summarized, and the economic and environmental benefits of bio-asphalt binder were evaluated. The analysis shows that pavement biomass materials with potential for practical application can be divided into three categories: bio-oil, bio-fiber, and bio-filler. Adding bio-oil to modify or extend the virgin asphalt binder can mostly improve the low temperature performance of asphalt binder. Adding styrene-butadienestyrene (SBS) or other preferable bio-components for composite modification will have a further improved effect. Most of the asphalt mixtures prepared by using bio-oil modified asphalt binders have improved the low temperature crack resistance and fatigue resistance of asphalt mixtures, but the high temperature stability and moisture resistance may decrease. As a rejuvenator, most bio-oils can restore the high and low temperature performance of aged asphalt and recycled asphalt mixture, and improve fatigue resistance. Adding bio-fiber could significantly improve the high temperature stability, low temperature crack resistance and moisture resistance of asphalt mixtures. Biochar as a bio-filler can slow down the asphalt aging process and some other bio-fillers can improve the high temperature stability and fatigue resistance of asphalt binders. Through calculation, it is found that the cost performance of bio-asphalt has the ability to surpass conventional asphalt and has economic benefits. The use of biomass materials for pavements not only reduces pollutants, but also reduces the dependence on petroleum-based products. It has significant environmental benefits and development potential.
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| 2. |
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| 3. |
- Ullah, I., et al.
(author)
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Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes
- 2018
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In: Journal of Clinical Investigation. - : American Society for Clinical Investigation. - 0021-9738 .- 1558-8238. ; 128:4, s. 1355-1370
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Journal article (peer-reviewed)abstract
- Metastatic breast cancers are still incurable. Characterizing the evolutionary landscape of these cancers, including the role of metastatic axillary lymph nodes (ALNs) in seeding distant organ metastasis, can provide a rational basis for effective treatments. Here, we have described the genomic analyses of the primary tumors and metastatic lesions from 99 samples obtained from 20 patients with breast cancer. Our evolutionary analyses revealed diverse spreading and seeding patterns that govern tumor progression. Although linear evolution to successive metastatic sites was common, parallel evolution from the primary tumor to multiple distant sites was also evident. Metastatic spreading was frequently coupled with polyclonal seeding, in which multiple metastatic subclones originated from the primary tumor and/or other distant metastases. Synchronous ALN metastasis, a well-established prognosticator of breast cancer, was not involved in seeding the distant metastasis, suggesting a hematogenous route for cancer dissemination. Clonal evolution coincided frequently with emerging driver alterations and evolving mutational processes, notably an increase in apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like-associated (APOBEC-associated) mutagenesis. Our data provide genomic evidence for a role of ALN metastasis in seeding distant organ metastasis and elucidate the evolving mutational landscape during cancer progression.
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| 4. |
- Pauwels, D., et al.
(author)
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Gamow-Teller decay population of Ni-64 levels in the decay of 1(+) Co-64
- 2012
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 86:6, s. 064318-
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Journal article (peer-reviewed)abstract
- The Co-64 beta-decay feeding levels in the well-studied Ni-64 nucleus were investigated. Whereas the previously known Co-64 decay scheme merely contained 2 gamma rays, the decay scheme established in this work contains 18, of which 5 are observed in this work and 6 were previously observed in an (n, gamma) study but not placed in the Ni-64 level scheme. Surprisingly, one additional level-placed at an excitation energy of 3578.7 keV-could be determined. The observed beta-decay paths involve allowed nu f(5/2) -> pi f(7/2) and nu p(1/2) -> pi p(3/2) transitions. Three strongly fed levels around 4 MeV are interpreted to possess possible proton-intruder character.
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| 5. |
- Radulov, D., et al.
(author)
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beta decay of Mn-61 to levels in Fe-61
- 2013
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In: Physical Review C. Nuclear Physics. - : American Physical Society. - 0556-2813 .- 1089-490X. ; 88:1, s. 014307-
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Journal article (peer-reviewed)abstract
- A detailed beta-decay study of Mn-61 is presented, yielding extended information on the level structure of Fe-61. Pure beams were obtained at ISOLDE, CERN, after selective laser ionization and mass separation of fission products from the bombardment of a UCx target by 1.4-GeV protons. The beta and gamma information was detected by two MiniBall clusters and three Delta E plastic scintillators. The new Mn-61 decay scheme reveals 48 gamma transitions, distributed over 20 excited states. A comparison to the decay scheme of Mn-59 and excited states in Fe-59 is made. Shell-model calculations with two different interactions are performed in order to compare the nuclear structure of the two neighboring odd-A iron isotopes. Tentative spin and parities of several excited states in Fe-61 are assigned on the basis of beta-decay feeding patterns in both Fe-59,Fe-61 and of results from the theoretical shell-model calculations.
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| 6. |
- Williams, Cecilia, 1969-, et al.
(author)
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Assessment of sequence-based p53 gene analysis in human breast cancer : messenger RNA in comparison with genomic DNA targets.
- 1998
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In: Clinical Chemistry. - : Oxford University Press (OUP). - 0009-9147 .- 1530-8561. ; 44:3
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Journal article (peer-reviewed)abstract
- The high prevalence of p53 mutations in human cancers and the suggestion from several groups that the presence or absence of p53 mutations might have both prognostic and therapeutic consequences point to the importance of optimal methods for p53 determination. Several strategies exploring this have been described, based either on mRNA or genomic DNA as a template. However, no comparative study on the reliability of the two templates has been performed. The principal aim of this study was to study the concordance of RNA- and DNA-based direct sequencing methods in detecting p53 mutations in breast tumors. In 100 tumors, 22 mutations were detected by both methods. Furthermore, one stop mutation, two splice-site mutations, and one intron alteration were found only by genomic sequencing. In addition, the comparative study suggests that cells with missense mutations have increased steady-state concentrations of p53-specific mRNA, in contrast to cells with a gene encoding a truncated protein.
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| 7. |
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| 8. |
- Bergh, Cathrine, et al.
(author)
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Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
- 2024
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In: eLife. - : eLife Sciences Publications, Ltd. - 2050-084X. ; 12, s. 2023-01
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Journal article (peer-reviewed)abstract
- Ligand-gated ion channels transduce electrochemical signals in neurons and other excitable cells. Aside fromcanonical ligands, phospholipids are thought to bind specifically to the transmembrane domain of several ionchannels. However, structural details of such lipid contacts remain elusive, partly due to limited resolution ofthese regions in experimental structures. Here, we discovered multiple lipid interactions in the channel GLICby integrating cryo-electron microscopy and large-scale molecular simulations. We identified 25 bound lipidsin the GLIC closed state, a conformation where none, to our knowledge, were previously known. Three lipidswere associated with each subunit in the inner leaflet, including a buried interaction disrupted in mutantsimulations. In the outer leaflet, two intrasubunit sites were evident in both closed and open states, whilea putative intersubunit site was preferred in open-state simulations. This work offers molecular details ofGLIC-lipid contacts particularly in the ill-characterized closed state, testable hypotheses for state-dependentbinding, and a multidisciplinary strategy for modeling protein-lipid interactions.
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