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- Larsson, Susanna C., et al.
(författare)
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Coffee and black tea consumption and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort
- 2009
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Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 20:10, s. 2039-2044
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Tidskriftsartikel (refereegranskat)abstract
- Coffee and tea consumption has been inconsistently associated with the risk of breast cancer. We examined the associations of caffeinated coffee and black tea consumption with the incidence of breast cancer, overall and by estrogen receptor (ER) and progesterone receptor (PR) status of the tumor, in the Swedish Mammography Cohort. We prospectively followed up 61,433 women who were cancer free at baseline in 1987-1990. Coffee and tea consumption was assessed with a food-frequency questionnaire administered at baseline and in 1997. Incident invasive breast cancer cases were ascertained by linkage with Swedish Cancer registers. Over a mean follow-up of 17.4 years, through December 2007, there were 2,952 incident cases of invasive breast cancer identified. Coffee consumption was not associated with risk of overall breast cancer (multivariate relative risk (RR) for a parts per thousand yen4 cups/day versus < 1 cup/day = 1.02; 95% CI, 0.87-1.20) or with any subtype defined by ER and PR status. Black tea consumption was significantly positively associated with risk of overall breast cancer and ER+/PR+ tumors. The multivariate RRs comparing a parts per thousand yen2 cups/day of tea with no consumption were 1.22 (95% CI, 1.05-1.42) for overall breast cancer and 1.36 (95% CI, 1.09-1.69) for ER+/PR+ tumors. Findings from this prospective study do not support a role of coffee consumption in the development of breast cancer but suggest that black tea consumption may be positively associated with risk of ER+/PR+ tumors.
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- Larsson, Susanna C., et al.
(författare)
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Conjugated linoleic acid intake and breast cancer risk in a prospective cohort of Swedish women
- 2009
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 90:3, s. 556-560
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Tidskriftsartikel (refereegranskat)abstract
- Background: Studies in animals and in vitro suggest that conjugated linoleic acids (CLAs), a group of fatty acids found mainly in dairy products and in the meat of ruminants, have protective effects against mammary carcinogenesis. However, findings from epidemiologic studies on CLA intake in relation to breast cancer risk are sparse and inconsistent. Objective: The objective was to examine prospectively the association between CLA intake and the incidence of invasive breast cancer in the Swedish Mammography Cohort. Design: In 1987-1990, 61,433 cancer-free women completed a food-frequency questionnaire from which we estimated each woman's CLA intake. Cox proportional hazards models were used to estimate relative risks, adjusted for breast cancer risk factors. Results: During a mean follow-up of 17.4 y, 2952 incident cases of breast cancer were ascertained. In multivariate analyses, no significant association was observed between dietary CLA intake and risk of breast cancer, overall or by estrogen receptor (ER) and progesterone receptor (PR) status. The multivariate relative risks (95% CI) for the highest quintile of CLA intake (>= 155.7 mg/d) compared with the lowest quintile (<78.1 mg/d) were 1.04 (0.92, 1.17) for overall breast cancer, 1.09 (0.90, 1.31) for ER+/PR+ tumors, 1.09 (0.78, 1.53) for ER+/PR- tumors, and 0.84 (0.57, 1.24) for ER-/PR-tumors. Conclusion: The results provide no evidence of a protective effect of CLA against breast cancer development in women.
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- Larsson, Susanna C., et al.
(författare)
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Consumption of sugar and sugar-sweetened foods and the risk of pancreatic cancer in a prospective study
- 2006
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 84:5, s. 1171-1176
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Tidskriftsartikel (refereegranskat)abstract
- Background: Emerging evidence indicates that hyperglycemia and hyperinsulinemia may be implicated in the development of pancreatic cancer. Frequent consumption of sugar and high-sugar foods may increase the risk of pancreatic cancer by inducing frequent postprandial hyperglycemia, increasing insulin demand, and decreasing insulin sensitivity.Objective: The objective of the study was to examine prospectively the association of the consumption of added sugar (ie, sugar added to coffee, tea, cereals, etc) and of high-sugar foods with the risk of pancreatic cancer in a population-based cohort study of Swedish women and men.Design: A food-frequency questionnaire was completed in 1997 by 77 797 women and men aged 45-83 y who had no previous diagnosis of cancer or history of diabetes. The participants were followed through June 2005.Results: During a mean follow-up of 7.2 y, we identified 131 incident cases of pancreatic cancer. The consumption of added sugar, soft drinks, and sweetened fruit soups or stewed fruit was positively associated with the risk of pancreatic cancer. The multivariate hazard ratios for the highest compared with the lowest consumption categories were 1.69 (95% CI: 0.99, 2.89; P for trend = 0.06) for sugar, 1.93 (1.18, 3.14; P for trend = 0.02) for soft drinks, and 1.51 (0.97, 2.36; P for trend 0.05) for sweetened fruit soups or stewed fruit.Conclusion: High consumption of sugar and high-sugar foods may be associated with a greater risk of pancreatic cancer.
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- Larsson, Susanna C., et al.
(författare)
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Dietary acrylamide intake and risk of colorectal cancer in a prospective cohort of men
- 2009
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 45:4, s. 513-516
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Tidskriftsartikel (refereegranskat)abstract
- Acrylamide is a probable human carcinogen that causes cancer at multiple sites in animal models. However, whether dietary acrylamide intake increases the risk of colorectal cancer in humans is unclear. We examined the association between dietary acrylamide intake and colorectal cancer incidence in the Cohort of Swedish Men, a population-based prospective cohort of 45 306 men who completed a food-freuency questionnaire at enrolment in 1997. During a mean follow-up of 9.3 years, we ascertained 676 incident colorectal cancer cases. Compared with the lowest quartile of acrylamide intake (<29.6 mu g/d), the multivariate rate ratios for the highest quartile (>= 41.7 mu g/d) were 0.95 (95% confidence interval (CI) 0.74-1.20) for colorectal cancer, 0.97 (95% CI 0.71-1.31) for colon cancer and 0.91 (95% CI 0.62-1.34) for rectal cancer. in conclusion, this study provides no evidence that dietary acrylamide in amounts typically consumed by Swedish men is associated with risk of colorectal cancer.
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- Larsson, Susanna C., et al.
(författare)
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Dietary carotenoids and risk of hormone receptor-defined breast cancer in a prospective cohort of Swedish women
- 2010
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Ingår i: European Journal of Cancer. - : Elsevier BV. - 0959-8049 .- 1879-0852. ; 46:6, s. 1079-1085
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Tidskriftsartikel (refereegranskat)abstract
- Carotenoids have antioxidant and antiproliferative properties and may reduce the risk of breast cancer. We examined the association between dietary carotenoids and risk of invasive breast cancer in the Swedish Mammography Cohort, a population-based cohort of 36,664 women who completed a questionnaire in 1997. During a mean follow-up of 9.4 years, 1008 women were diagnosed with incident breast cancer. Dietary carotenoids were not significantly associated with the risk of breast cancer overall or with any subtype defined by oestrogen receptor (ER) and progesterone receptor (PR) status. However, dietary alpha-carotene and beta-carotene were inversely associated with the risk of ER-PR-breast cancer among ever smokers. Among ever smokers, the multivariable relative risks of ER-PR-breast cancer comparing the highest with the lowest quintile of intake were 0.32 (95% confidence interval (CI): 0.11-0.94; P-trend = 0.01) for alpha-carotene and 0.35 (95% Cl: 0.12-0.99; P-trend = 0.03) for beta-carotene. The risk of breast cancer also decreased with increasing intakes of alpha-carotene (P-trend = 0.02) and beta-carotene (P-trend = 0.01) among women who did not use dietary supplements. These findings suggest that dietary alpha-carotene and beta-carotene are inversely associated with the risk of breast cancer among smokers and among women who do not use dietary supplements.
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- Larsson, Susanna C., et al.
(författare)
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Folate Intake and Risk of Breast Cancer by Estrogen and Progesterone Receptor Status in a Swedish Cohort
- 2008
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 17:12, s. 3444-3449
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Tidskriftsartikel (refereegranskat)abstract
- Background: Folate is a B vitamin involved in one-carbon metabolism and has been postulated to influence the risk of breast cancer. However, epidemiologic studies of folate intake in relation to breast cancer risk are inconclusive. We examined the association between dietary folate intake and the risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumor in the Swedish Mammography Cohort. Methods: Our study population consisted of 61,433 women who completed a food frequency questionnaire at baseline (1987-1990) and again in 1997. Cox proportional hazards models were used to estimate rate ratios (RR) with 95% confidence intervals (95% CI). Results: During an average of 17.4 years of follow-up, 2,952 incident cases of invasive breast cancer were ascertained. We observed no association between dietary folate intake and risk of total breast cancer or ER+/PR+ or ER-/PR- tumors. The multivariate RR of total breast cancer comparing extreme quintiles of folate intake was 1.01 (95%a CI, 0.90-1.13; P-trend = 0.84). However, folate intake was inversely associated with risk of ER+/PR- breast cancer (n = 417 cases; RR for highest versus lowest quintile, 0.79; 95% CI, 0.59-1.07; Ptrend = 0.01). Results did not vary by alcohol intake or menopausal status. Conclusions: These findings do not support an overall association between folate intake and risk of breast cancer but suggest that folate intake may be inversely associated with ER+/PR- tumors.
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- Larsson, Susanna C., et al.
(författare)
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Fruit and vegetable consumption and incidence of gastric cancer : a prospective study
- 2006
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 15:10, s. 1998-2001
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Tidskriftsartikel (refereegranskat)abstract
- Background: Whether fruit and vegetable consumption may confer protection from gastric cancer remains controversial.Methods: We prospectively investigated the association between consumption of fruits and vegetables and the incidence of gastric cancer among participants from two population-based cohort studies: 36,664 women in the Swedish Mammography Cohort and 45,338 men in the Cohort of Swedish Men. Participants completed a food-frequency questionnaire in 1997 and were followed up for cancer incidence through June 2005. Cox proportional hazards models were used to estimate multivariate hazard ratios (HR) and 95% confidence intervals (95% CI).Results: During a mean follow-up of 7.2 years, we ascertained 139 incident cases of gastric cancer. Vegetable consumption was inversely associated with risk of gastric cancer, whereas no significant association was observed for fruit consumption. After controlling for age and other risk factors, women and men who consumed >= 2.5 servings/d of vegetables had a HR of 0.56 (95% CI, 0.34-0.93) for developing gastric cancer compared with those who consumed < 1 serving/d. The respective HR for fruit consumption was 0.86 (95% CI, 0.52-1.43). Among specific subgroups of vegetables, consumption of green leafy vegetables and root vegetables was inversely associated with risk of gastric cancer, the multivariate HRs comparing >= 3 servings/wk with < 0.5 serving/wk were 0.64 (95% CI, 0.42-0.99) for green leafy vegetables and 0.43 (95% CI, 0.27-0.69) for root vegetables.Conclusions: Frequent consumption of vegetables may reduce the risk of gastric cancer.
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