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Breast cancer in sy...
Breast cancer in systemic lupus erythematosus (SLE) : receptor status and treatment
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- Chan, K. (author)
- McGill University
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- Clarke, A. E. (author)
- University of Calgary
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- Ramsey-Goldman, R. (author)
- Northwestern University Feinberg School of Medicine
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- Foulkes, W. (author)
- McGill University
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- Tessier Cloutier, B. (author)
- British Columbia Cancer Agency
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- Urowitz, M. B. (author)
- University of Toronto
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- Gladman, D. (author)
- University of Toronto
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- Nived, O. (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Romero-Diaz, J. (author)
- Instituto Nacional de Ciencias Médicas y Nutrición
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- Petri, M. (author)
- Johns Hopkins University School of Medicine
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Ginzler, E. (author)
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- Fortin, P. R. (author)
- Laval University
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- Bae, S. C. (author)
- Hanyang University
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- Wallace, D. J. (author)
- Jonsson Comprehensive Cancer Center
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- Yelin, E. H. (author)
- University of Texas Health Science Centre
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- Bernatsky, Sasha (author)
- McGill University Health Center
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(creator_code:org_t)
- 2017-06-08
- 2018
- English 4 s.
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In: Lupus. - : SAGE Publications. - 0961-2033 .- 1477-0962. ; 27:1, s. 120-123
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: There is a decreased risk of breast cancer in systemic lupus erythematosus (SLE) versus the general population; little is known regarding the receptor status of breast cancers in SLE, or treatment. Methods: Breast cancer cases occurring after SLE diagnosis were ascertained through linkage with tumor registries. We determined breast cancer positivity for estrogen receptors (ER), progesterone receptors (PR), and/or Human Epidermal Growth Factor Receptor 2 (HER2), as well as cancer treatment. Results: We obtained information on ER, PR, and/or HER2 status for 63 SLE patients with breast cancer. Fifty-three had information on ER and/or PR status; 36 of these (69%) were ER positive. Thirty-six of the 63 had information on HER2 status; of these, 26 had complete information on all three receptors. Twenty-one of these 26 (81%) were HER2 negative; seven of 26(27%) were triple negative. All but one patient underwent surgery; 11.5% received both non-tamoxifen chemotherapy and radiotherapy, 16.4% radiotherapy without non-tamoxifen chemotherapy, and 14.7% received non-tamoxifen chemotherapy without radiotherapy. Conclusion: ER positivity was similar to historical general population figures, with a trend toward a higher proportion of triple-negative breast cancers in SLE (possibly reflecting the relatively young age of our SLE patients).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast cancer
- estrogen
- progesterone
- receptor
- systemic lupus erythematosus
Publication and Content Type
- art (subject category)
- ref (subject category)
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Lupus
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- By the author/editor
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Chan, K.
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Clarke, A. E.
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Ramsey-Goldman, ...
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Foulkes, W.
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Tessier Cloutier ...
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Urowitz, M. B.
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Gladman, D.
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Nived, O.
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Romero-Diaz, J.
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Petri, M.
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Ginzler, E.
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Fortin, P. R.
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Bae, S. C.
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Wallace, D. J.
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Yelin, E. H.
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Bernatsky, Sasha
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Lupus
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Lund University