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Sökning: WFRF:(Beuers Ulrich) > Trauner Michael

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1.
  • Fickert, Peter, et al. (författare)
  • Characterization of animal models for primary sclerosing cholangitis (PSC).
  • 2014
  • Ingår i: Journal of hepatology. - : Elsevier BV. - 1600-0641 .- 0168-8278. ; 60:6, s. 1290-1303
  • Forskningsöversikt (refereegranskat)abstract
    • Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.
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2.
  • Nevens, Frederik, et al. (författare)
  • A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.
  • 2016
  • Ingår i: The New England journal of medicine. - 1533-4406. ; 375:7, s. 631-43
  • Tidskriftsartikel (refereegranskat)abstract
    • Primary biliary cholangitis (formerly called primary biliary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase and bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients with this disease.
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