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1.	Greve, Anders M., et al. (author) Contrasting Hemodynamic Mechanisms of Losartan- vs. Atenolol-Based Antihypertensive Treatment : A LIFE Study 2012 In: American Journal of Hypertension. - : Oxford University Press (OUP). - 0895-7061 .- 1941-7225. ; 25:9, s. 1017-1023 Journal article (peer-reviewed)abstract BACKGROUND Pharmaceutical differences in central hemodynamics might influence cardiac response to antihypertensive treatment despite similar lowering of brachial blood pressure (BP). METHODS Data from all patients with at least two echocardiographic examinations in the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) echocardiographic substudy (n = 801); high-risk patients on losartan- vs. atenolol-based antihypertensive therapy. Echocardiography was performed annually for 4 years to measure stroke index (SI), heart rate, cardiac index (CI), conduit artery stiffness assessed as pulse pressure/stroke index (PP/SI) and total peripheral resistance index (TPRI). RESULTS Atenolol- and losartan-based therapy reduced BP similarly (cumulative difference in mean brachial blood pressure 0.3 mm Hg, P = 0.65). After 4 years the cumulative means of SI and heart rate were 1.8 ml/m(2) higher and 5.7 beats/min lower on atenolol-based treatment, respectively (both P < 0.001). This kept CI below baseline in atenolol-treated patients, whereas in the losartan group CI was unchanged from baseline throughout the study. TPRI was decreased more and remained lower in the losartan group (cumulative difference in mean TPRI 287 dynes/sec(-5)/cm/m(2), P < 0.001). These findings partly explained univariate differences in systolic- and diastolic function indices between the two treatments; fully adjusted losartan was only associated with a smaller left atrial diameter (cumulative mean difference 0.07 cm; 95% confidence intervals, -0.13 to -0.01, P = 0.03). CONCLUSIONS Contrasting hemodynamics impacted cardiac response to similar reductions in brachial BP on losartan- vs. atenolol-based therapy. The similar reduction of PP/SI suggests that the antihypertensive regimens used in the LIFE study had comparable effects on arterial stiffness (LIFE study; NCT00338260)
2.	Wachtell, Kristian, et al. (author) In-treatment midwall and endocardial fractional shortening predict cardiovascular outcome in hypertensive patients with preserved baseline systolic ventricular function : the Losartan intervention for endpoint reduction study 2010 In: Journal of Hypertension. - 0263-6352 .- 1473-5598. ; 28:7, s. 1541-1546 Journal article (peer-reviewed)abstract These results support a prognostic role for left ventricular myocardial function, as estimated by stress-corrected MWS, during aggressive BP lowering in hypertensive patients with preserved ejection fraction at baseline evaluation.
3.	Wachtell, Kristian, et al. (author) In-treatment reduced left atrial diameter during antihypertensive treatment is associated with reduced new-onset atrial fibrillation in hypertensive patients with left ventricular hypertrophy : the LIFE study 2010 In: Blood Pressure. - : Informa UK Limited. - 0803-7051 .- 1651-1999. ; 19:3, s. 169-175 Journal article (peer-reviewed)abstract LA diameter at baseline and during antihypertensive treatment were equally strong predictors of new-onset AF independent of the level of arterial pressure, LV mass and other covariates. Prevention of AF during antihypertensive treatment may be improved by antihypertensive therapy that reduces LA size in addition to controlling blood pressure.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Boman, Kurt (3); Devereux, Richard B. (3); Wachtell, Kristian (3); Gerdts, Eva (3); Nieminen, Markku S. (3); Palmieri, Vittor... (3)Undo refine; show more...; Okin, Peter M. (2); Aurigemma, Gerard P. (2); Olsen, Michael H. (2); Dahlöf, Björn (2); Rokkedal, Jens E (2); Greve, Anders M. (1); Dahlof, Bjorn (1); Papademetriou, Vasil ... (1); Omvik, Per (1); Bella, Jonathan N. (1); Lonnebakken, Mai T. (1); Olsen, Michael Hecht (1); show less...

University: Umeå University (3)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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