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- Geser, F, et al.
(författare)
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The European Multiple System Atrophy-Study Group (EMSA-SG)
- 2005
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Ingår i: Journal of Neural Transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 112:12, s. 1677-1686
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Tidskriftsartikel (refereegranskat)abstract
- Introduction. The European Multiple System Atrophy-Study Group (EMSA-SG) is an academic network comprising 23 centers across Europe and Israel that has constituted itself already in January 1999. This international forum of established experts under the guidance of the University Hospital of Innsbruck as coordinating center is supported by the 5th framework program of the European Union since March 2001 (QLK6-CT-2000-00661). Objectives. Primary goals of the network include (1) a central Registry for European multiple system atrophy (MSA) patients, (2) a decentralized DNA Bank, (3) the development and validation of the novel Unified MSA Rating Scale (UMSARS), (4) the conduction of a Natural History Study (NHS), and (5) the planning or implementation of interventional therapeutic trials. Methods. The EMSA-SG Registry is a computerized data bank localized at the coordinating centre in Innsbruck collecting diagnostic and therapeutic data of MSA patients. Blood samples of patients and controls are recruited into the DNA Bank. The UMSARS is a novel specific rating instrument that has been developed and validated by the EMSA-SG. The NHS comprises assessments of basic anthropometric data as well as a range of scales including the UMSARS, Unified Parkinson's Disease Rating Scale (UPDRS), measures of global disability, Red Flag list, MMSE (Mini Mental State Examination), quality of live measures, i.e. EuroQoL 5D (EQ-5D) and Medical Outcome Study Short Form (SF-36) as well as the Beck Depression Inventory (BDI). In a subgroup of patients dysautonomic features are recorded in detail using the Queen Square Cardiovascular Autonomic Function Test Battery, the Composite Autonomic Symptom Scale (COMPASS) and measurements of residual urinary volume. Most of these measures are repeated at 6-monthly follow up visits for a total study period of 24 months. Surrogate markers of the disease progression are identified by the EMSA-SG using magnetic resonance and diffusion weighted imaging (MRI and DWI, respectively). Results. 412 patients have been recruited into the Registry so far. Probable MSA-P was the most common diagnosis (49% of cases). 507 patients donated DNA for research. 131 patients have been recruited into the NHS. There was a rapid deterioration of the motor disorder (in particular akinesia) by 26.1% of the UMSARS II, and - to a lesser degree - of activities of daily living by 16.8% of the UMSARS I in relation to the respective baseline scores. Motor progression was associated with low motor or global disability as well as low akinesia or cerebellar subscores at baseline. Mental function did not deteriorate during this short follow up period. Conclusion. For the first time, prospective data concerning disease progression are available. Such data about the natural history and prognosis of MSA as well as surrogate markers of disease process allow planning and implementation of multi-centre phase II/III neuroprotective intervention trials within the next years more effectively. Indeed, a trial on growth hormone in MSA has just been completed, and another on minocycline will be completed by the end of this year.
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- Carmelo, J. M. P., et al.
(författare)
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Correlation effects in one-dimensional systems
- 2007
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Ingår i: Strongly Correlated Systems, Coherence and Entanglement. - Hackensack, N.J. : World Scientific. - 9789812705723 ; , s. 3-27
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- We review developments concerning the effect of correlations on the electronic properties of one-dimensional systems, focusing our analysis on the one-dimensional Hubbard model. We consider methods used to describe the exotic properties of these systems, ranging from bosonization associated with the Tomonaga and Luttinger liquid behavior, to the Bethe ansatz solution, referring to all energy scales of solvable quantum problems and the pseudoparticle description. We use that description to study the model energy spectrum and the low-energy quantities. In the ensuing companion chapter we discuss the relation of the electronic operators to these quantum objects.
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- Carmelo, J. M. P., et al.
(författare)
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Dynamical and spectral properties of low dimensional materials
- 2007
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Ingår i: Strongly Correlated Systems, Coherence and Entanglement. - Hackensack, N.J. : World Scientific. - 9789812705723 ; , s. 29-59
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter follows its companion, chapter 1. Here we review different methods based on the Bethe ansatz solution of the one-dimensional Hubbard model, in order to study quantities related to charge transport and the momentum dependent conductivity. Moreover, we report recent developments on finite-energy dynamical properties. This is achieved by introducing new entities called pseudofermions which are basically free, in the sense that their energies are additive, and where the effect of the interactions appears through phase shifts that are absorbed by their discrete momentum values. The resulting pseudofermion dynamical theory enables the evaluation of matrix elements between energy eigen-states and hence the derivation of finite energy expressions for the one- and two-electron correlation and spectral functions. Comparison with experimental results is also discussed.
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