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Prevalence and rele...
Prevalence and relevance of abnormal glucose metabolism in acute coronary syndromes : insights from the PLATelet inhibition and patient Outcomes (PLATO) trial
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- Åkerblom, Axel, 1977- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27708 USA;Uppsala Clin Res Ctr, Hammarskjolds Vag 38, S-75185 Uppsala, Sweden
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- Wojdyla, Daniel (författare)
- Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27708 USA
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- Steg, Philippe Gabriel (författare)
- INSERM, U1148, Paris, France;Hop Bichat Claude Bernard, AP HP, Dept Hosp Univ FIRE, Paris, France;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France;Imperial Coll, NHLI, ICMS, Royal Brompton Hosp, London, England
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- Wallentin, Lars, 1943- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- James, Stefan, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Budaj, Andrzej (författare)
- Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland
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- Katus, Hugo A. (författare)
- Univ Klinikum Heidelberg, Med Klin, Heidelberg, Germany
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- Himmelmann, Anders (författare)
- AstraZeneca Res & Dev, Molndal, Sweden
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- Huber, Kurt (författare)
- Wilhelminen Hosp, Dept Cardiol & Intens Care Med, Vienna, Austria;Sigmund Freud Univ, Sch Med, Vienna, Austria
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- Siegbahn, Agneta, 1947- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi
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- Storey, Robert F. (författare)
- Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England
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- Becker, Richard C. (författare)
- Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27708 USA;Acad Hlth Ctr, Div Cardiovasc Hlth & Dis, Heart Lung & Vasc Inst, Cincinnati, OH USA
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(creator_code:org_t)
- 2019-09-11
- 2019
- Engelska.
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Ingår i: Journal of Thrombosis and Thrombolysis. - : Springer. - 0929-5305 .- 1573-742X. ; 48:4, s. 563-569
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Diabetes mellitus (DM) and abnormal glucose metabolism are associated with cardiovascular (CV) disease. We investigated the prevalence and prognostic importance of dysglycaemia in patients with acute coronary syndromes (ACS) in the PLATelet inhibition and patient Outcomes (PLATO) trial. Diabetes was defined as known diabetes or HbA1c >= 6.5% or non-fasting glucose >= 11.1 mmol/L on admission, prediabetes as HbA1c >= 5.7% but < 6.5%, and no diabetes as HbA1c < 5.7%. The primary endpoint was the composite of CV death, spontaneous myocardial infarction type 1 (sMI) or stroke at 12 months. Multivariable Cox regression models, adjusting for baseline characteristics, and biomarkers NT-proBNP and troponin I, were used to explore the association between glycaemia and outcome. On admission, 16,007 (86.1%) patients had HbA1c and/or glucose levels available and were subdivided into DM 38.5% (6160) (1501 patients had no previous DM diagnosis), prediabetes 38.8% (6210), and no DM 22.7% (3637). Kaplan Meier event rates at 12 months for CV death, sMI or stroke per subgroups were 14.5% (832), 9.0% (522), and 8.5% (293), respectively with multivariable adjusted HRs, versus no diabetes, for diabetes: 1.71 (1.50-1.95) and for prediabetes 1.03 (0.90-1.19). Corresponding event rates for CV death were 6.9% (391), 3.4% (195) and 3.0% (102), respectively, with adjusted HRs for patients with DM of: 1.92 (1.42-2.60) and for prediabetes 1.02 (0.79-1.32). Abnormal glucose metabolism is common in ACS patients, but only patients with definite DM have an increased CV risk, indicating that prediabetes is not immediately associated with worse CV outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Diabetes
- Pre-diabetes
- Hemoglobin A1C
- Acute coronary syndromes
- Myocardial infarction
- Risk prediction
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Åkerblom, Axel, ...
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Wojdyla, Daniel
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James, Stefan, 1 ...
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Budaj, Andrzej
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Katus, Hugo A.
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Huber, Kurt
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Storey, Robert F ...
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Becker, Richard ...
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