| 1. |
- Aaltonen, T., et al.
(författare)
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Combination of Tevatron Searches for the Standard Model Higgs Boson in the W+W- Decay Mode
- 2010
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 104:6, s. 061802-
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Tidskriftsartikel (refereegranskat)abstract
- We combine searches by the CDF and D0 Collaborations for a Higgs boson decaying to W+W-. The data correspond to an integrated total luminosity of 4.8 (CDF) and 5.4 (D0) fb(-1) of p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron collider. No excess is observed above background expectation, and resulting limits on Higgs boson production exclude a standard model Higgs boson in the mass range 162-166 GeV at the 95% C.L.
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| 2. |
- Fenstermacher, M.E., et al.
(författare)
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DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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| 3. |
- Brownstein, Catherine A., et al.
(författare)
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An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge
- 2014
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Ingår i: Genome Biology. - : Springer Science and Business Media LLC. - 1465-6906 .- 1474-760X. ; 15:3, s. R53-
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challenge was designed to spur convergence in methods for diagnosing genetic disease starting from clinical case history and genome sequencing data. DNA samples were obtained from three families with heritable genetic disorders and genomic sequence data were donated by sequencing platform vendors. The challenge was to analyze and interpret these data with the goals of identifying disease-causing variants and reporting the findings in a clinically useful format. Participating contestant groups were solicited broadly, and an independent panel of judges evaluated their performance. Results: A total of 30 international groups were engaged. The entries reveal a general convergence of practices on most elements of the analysis and interpretation process. However, even given this commonality of approach, only two groups identified the consensus candidate variants in all disease cases, demonstrating a need for consistent fine-tuning of the generally accepted methods. There was greater diversity of the final clinical report content and in the patient consenting process, demonstrating that these areas require additional exploration and standardization. Conclusions: The CLARITY Challenge provides a comprehensive assessment of current practices for using genome sequencing to diagnose and report genetic diseases. There is remarkable convergence in bioinformatic techniques, but medical interpretation and reporting are areas that require further development by many groups.
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| 4. |
- Regev, A, et al.
(författare)
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The Human Cell Atlas
- 2017
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Ingår i: eLife. - : ELIFE SCIENCES PUBLICATIONS LTD. - 2050-084X. ; 6
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Tuskan, G A, et al.
(författare)
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The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 313:5793, s. 1596-604
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Tidskriftsartikel (refereegranskat)abstract
- We report the draft genome of the black cottonwood tree, Populus trichocarpa. Integration of shotgun sequence assembly with genetic mapping enabled chromosome-scale reconstruction of the genome. More than 45,000 putative protein-coding genes were identified. Analysis of the assembled genome revealed a whole-genome duplication event; about 8000 pairs of duplicated genes from that event survived in the Populus genome. A second, older duplication event is indistinguishably coincident with the divergence of the Populus and Arabidopsis lineages. Nucleotide substitution, tandem gene duplication, and gross chromosomal rearrangement appear to proceed substantially more slowly in Populus than in Arabidopsis. Populus has more protein-coding genes than Arabidopsis, ranging on average from 1.4 to 1.6 putative Populus homologs for each Arabidopsis gene. However, the relative frequency of protein domains in the two genomes is similar. Overrepresented exceptions in Populus include genes associated with lignocellulosic wall biosynthesis, meristem development, disease resistance, and metabolite transport.
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| 6. |
- Campbell, I. A., et al.
(författare)
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Extended scaling analysis of the S=1/2 Ising ferromagnet on the simple cubic lattice
- 2011
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 83:1
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Tidskriftsartikel (refereegranskat)abstract
- It is often assumed that for treating numerical (or experimental) data on continuous transitions the formal analysis derived from the renormalization-group theory can only be applied over a narrow temperature range, the "critical region"; outside this region correction terms proliferate rendering attempts to apply the formalism hopeless. This pessimistic conclusion follows largely from a choice of scaling variables and scaling expressions, which is traditional but very inefficient for data covering wide temperature ranges. An alternative "extended scaling" approach can be made where the choice of scaling variables and scaling expressions is rationalized in the light of well established high-temperature series expansion developments. We present the extended scaling approach in detail, and outline the numerical technique used to study the three-dimensional (3D) Ising model. After a discussion of the exact expressions for the historic 1D Ising spin chain model as an illustration, an exhaustive analysis of high quality numerical data on the canonical simple cubic lattice 3D Ising model is given. It is shown that in both models, with appropriate scaling variables and scaling expressions (in which leading correction terms are taken into account where necessary), critical behavior extends from T-c up to infinite temperature.
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| 7. |
- Conrad, Jan, et al.
(författare)
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Beam test performance and simulation of prototypes for the ALICE silicon pixel detector
- 2007
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 573:1-2, s. 1-3
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Tidskriftsartikel (refereegranskat)abstract
- The silicon pixel detector (SPD) of the ALICE experiment in preparation at the Large Hadron Collider (LHC) at CERN is designed to provide the precise vertex reconstruction needed for measuring heavy flavor production in heavy ion collisions at very high energies and high multiplicity. The SPD forms the innermost part of the Inner Tracking System (ITS) which also includes silicon drift and silicon strip detectors. Single assembly prototypes of the ALICE,SPD have been tested at the CERN SPS using high energy proton/pion beams in 2002 and 2003. We report on the experimental determination of the spatial precision. We also report on the first combined beam test with prototypes of the other ITS silicon detector technologies at the CERN SPS in November 2004. The issue of SPD simulation is briefly discussed.
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| 8. |
- Lundow, Per Håkan, et al.
(författare)
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Alternative phenomenological coupling parameter for finite-size analysis of numerical data at criticality
- 2010
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 82:2
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Tidskriftsartikel (refereegranskat)abstract
- We introduce a parameter W(beta,L) =(pi (2)/< m(2)>- 2/(pi-2) which like the kurtosis (Binder cumulant) is a phenomenological coupling characteristic of the shape of the distribution p(m) of the order parameter m. To demonstrate the use of the parameter we analyze extensive numerical data obtained from density-of-states measurements on the canonical simple-cubic spin-1/2 Ising ferromagnet, for sizes L=4 to L=256. Using the W parameter accurate estimates are obtained for the critical inverse temperature beta(c)=0.2216541(2), and for the thermal exponent nu=0.6308(4). In this system at least, corrections to finite-size scaling are significantly weaker for the W parameter than for the Binder cumulant.
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| 9. |
- Lundow, Per Håkan, et al.
(författare)
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Critical scaling to infinite temperature
- 2011
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Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 83:18
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Tidskriftsartikel (refereegranskat)abstract
- Three-dimensional Ising model ferromagnets on different lattices with nearest-neighbor interactions, and on simple-cubic lattices with equivalent interactions out to further neighbors, are studied numerically. The susceptibility data for all these systems are analyzed using the critical renormalization-group theory formalism over the entire temperature range above T-c with an appropriate choice of scaling variable and scaling expressions. Representative experimental data on a metallic ferromagnet (Ni) and an elementary fluid (Xe) are interpreted in the same manner so as to estimate effective coordination numbers.
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| 10. |
- Lundow, Per Håkan, et al.
(författare)
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Fortuin-Kasteleyn and damage-spreading transitions in random-bond Ising lattices
- 2012
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Ingår i: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics. - 1539-3755 .- 1550-2376. ; 86:4
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Tidskriftsartikel (refereegranskat)abstract
- The Fortuin-Kasteleyn and heat-bath damage-spreading temperatures T FK(p) and T DS(p) are studied on random-bond Ising models of dimensions 2-5 and as functions of the ferromagnetic interaction probability p; the conjecture that T DS(p)∼T FK(p) is tested. It follows from a statement by Nishimori that in any such system, exact coordinates can be given for the intersection point between the Fortuin-Kasteleyn T FK(p) transition line and the Nishimori line [p NL,FK, T NL,FK]. There are no finite-size corrections for this intersection point. In dimension 3, at the intersection concentration [p NL,FK], the damage spreading T DS(p) is found to be equal to T FK(p) to within 0.1%. For the other dimensions, however, T DS(p) is observed to be systematically a few percent lower than T FK(p).
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