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Search: WFRF:(Cao Liqiang) > Journal article

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  • Marcotte, Harold, et al. (author)
  • Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents Infection of Omicron lineages
  • 2024
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : NATL ACAD SCIENCES. - 0027-8424 .- 1091-6490. ; 121:3
  • Journal article (peer-reviewed)abstract
    • The emergence of Omicron lineages and descendent subvariants continues to present a severe threat to the effectiveness of vaccines and therapeutic antibodies. We have previ- ously suggested that an insufficient mucosal immunoglobulin A (IgA) response induced by the mRNA vaccines is associated with a surge in breakthrough infections. Here, we further show that the intramuscular mRNA and/or inactivated vaccines cannot suffi- ciently boost the mucosal secretory IgA response in uninfected individuals, particu- larly against the Omicron variant. We thus engineered and characterized recombinant monomeric, dimeric, and secretory IgAl antibodies derived from four neutralizing IgG monoclonal antibodies (mAbs 01A05, rmAb23, DXP-604, and XG014) targeting the receptor-binding domain of the spike protein. Compared to their parental IgG antibod- ies, dimeric and secretory IgAl antibodies showed a higher neutralizing activity against different variants of concern (VOCs), in part due to an increased avidity. Importantly, the dimeric or secretory IgAl form of the DXP-604 antibody significantly outperformed its parental IgG antibody, and neutralized the Omicron lineages BA.1, BA.2, and BA.4/5 with a 25- to 75-fold increase in potency. In human angiotensin converting enzyme 2 (ACE2) transgenic mice, a single intranasal dose of the dimeric IgA DXP-604 conferred prophylactic and therapeutic protection against Omicron BA.5. Thus, dimeric or secre- tory IgA delivered by nasal administration may potentially be exploited for the treatment Iand prevention of Omicron infection, thereby providing an alternative tool for combating immune evasion by the current circulating subvariants and, potentially, future VOCs.
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  • Zhang, Chenghang, et al. (author)
  • Characterizations of microstructure, crystallographic texture and mechanical properties of dissimilar friction stir welding joints for AA2024 and AA7075 under different tool shoulder end profiles
  • 2020
  • In: Materials Today Communications. - : Elsevier Ltd. - 2352-4928. ; 25, s. 101435-
  • Journal article (peer-reviewed)abstract
    • In this investigation, the influence of tool shoulder end profiles (concentric circle shoulder-CCS and three-helix shoulder-THS) and rotational speed (ROSP, 800, 1100, 1400 rpm) on microstructure and mechanical performance of the dissimilar FSW AA2024/7075 joints was analyzed in detail. The results indicated that the width of thermos-mechanical affected zone and the average grain size of nugget zone (NZ) in the CCS joints are lower than those in the THS joints, and they all increase with increasing the ROSP. There is a difference on the shear texture types generated in the different positions of the NZ in the CCS and THS joints. Tensile properties of the joints fabricated by employing the CCS tool are excellent compared to the THS tool. The maximum welding efficiency about 90.8 % can be obtained in the CCS joint at 1000 rpm. The fracture mode of the CCS and THS joints is ductile and brittle failure, respectively.
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  • Result 1-7 of 7

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