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Deciphering early h...
Deciphering early human pancreas development at the single-cell level
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- Ma, Zhuo (author)
- Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
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- Zhang, Xiaofei (author)
- Chinese Acad Sci, Peoples R China; Huazhong Univ Sci & Technol, Peoples R China; Hainan Med Univ, Peoples R China
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- Zhong, Wen (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Karolinska Inst, Sweden,Science for Life Laboratory
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- Yi, Hongyan (author)
- Hainan Med Univ, Peoples R China
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- Chen, Xiaowei (author)
- Chinese Acad Sci, Peoples R China
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- Zhao, Yinsuo (author)
- Chinese Acad Sci, Peoples R China
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- Ma, Yanlin (author)
- Hainan Med Univ, Peoples R China
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- Song, Eli (author)
- Chinese Acad Sci, Peoples R China
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- Xu, Tao (author)
- Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China; Guangzhou Lab, Peoples R China; Shandong First Med Univ, Peoples R China; Shandong First Med Univ, Peoples R China; Shandong Acad Med Sci, Peoples R China
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(creator_code:org_t)
- NATURE PORTFOLIO, 2023
- 2023
- English.
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In: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 14:1
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Understanding pancreas development can provide clues for better treatments of pancreatic diseases. However, the molecular heterogeneity and developmental trajectory of the early human pancreas are poorly explored. Here, we performed large-scale single-cell RNA sequencing and single-cell assay for transposase accessible chromatin sequencing of human embryonic pancreas tissue obtained from first-trimester embryos. We unraveled the molecular heterogeneity, developmental trajectories and regulatory networks of the major cell types. The results reveal that dorsal pancreatic multipotent cells in humans exhibit different gene expression patterns than ventral multipotent cells. Pancreato-biliary progenitors that generate ventral multipotent cells in humans were identified. Notch and MAPK signals from mesenchymal cells regulate the differentiation of multipotent cells into trunk and duct cells. Notably, we identified endocrine progenitor subclusters with different differentiation potentials. Although the developmental trajectories are largely conserved between humans and mice, some distinct gene expression patterns have also been identified. Overall, we provide a comprehensive landscape of early human pancreas development to understand its lineage transitions and molecular complexity. Here, the authors revealed molecular heterogeneity, developmental trajectory and regulatory network of early human pancreas development, and depict the whole progression of pancreatic organogenesis during the first trimester at the single-cell level.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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