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- Cristofer, Englund, 1977-, et al.
(författare)
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Future Applications of VANETs
- 2015
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Ingår i: Vehicular Ad Hoc Networks. - Cham : Springer Publishing Company. - 9783319154961 - 9783319154978 ; , s. 525-544
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Bokkapitel (refereegranskat)abstract
- Current transportation systems face great challenges due to the increasing mobility. Traffic accidents, congestion, air pollution, etc., are all calling for new methods to improve the transportation system. With the US legislation in progress over vehicle communications and EU’s finalization of the basic set of standards over cooperative intelligent transportation systems (C-ITS), vehicular ad hoc network (VANET) based applications are expected to address those challenges and provide solutions for a safer, more efficient and sustainable future intelligent transportation systems (ITS). In this chapter, transportation challenges are firstly summarized in respect of safety, efficiency, environmental threat, etc. A brief introduction of the VANET is discussed along with state of the art of VANET-based applications. Based on the current progress and the development trend of VANET, a number of new features of future VANET are identified, together with a set of potential future ITS applications. The on-going research and field operational test projects, which are the major enabling efforts for the future VANET-based C-ITS, are presented. The chapter is of great interest to readers working within ITS for current development status and future trend within the C-ITS area. It is also of interest to general public for an overview of the VANET enabled future transportation system. © Springer International Publishing Switzerland 2015.
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| 2. |
- Huang, Hongyun, et al.
(författare)
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Clinical neurorestorative cell therapies for stroke
- 2021
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Ingår i: NANOMEDICINE AND NEUROPROTECTION IN BRAIN DISEASES. - : ELSEVIER ACADEMIC PRESS INC. - 9780323901628 ; , s. 231-247
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Bokkapitel (refereegranskat)abstract
- Clinical neurorestorative cell therapies for stroke have been explored for over 20 years. Majority cell therapies have shown neurorestorative effects for stroke on non-double-blind studies. In this review, we summarize types of cell transplantation, transplanted routes, therapeutic time windows, dosage, results of exploring trials or clinical studies, results of multicenter, double-blind or observing-blind, randomized, placebo-controlled clinical trials. The clinical application prospects of majority cell therapies for stroke need to prove their neurorestorative effects through trials with higher-level evidence-based medical evidence. Currently olfactory ensheathing cell is only one kind of cell to show neurorestorative effects through multicenter, double-blind, randomized, placebo-controlled clinical trials, which should be explored to optimize themselves effects and combination with others.
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| 3. |
- Li, Cong, et al.
(författare)
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Network pharmacological mechanism of Cinobufotalin against glioma
- 2021
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Ingår i: NANOMEDICINE AND NEUROPROTECTION IN BRAIN DISEASES. - : ELSEVIER ACADEMIC PRESS INC. - 9780323901628 ; , s. 119-137
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Bokkapitel (refereegranskat)abstract
- Objective: Cinobufotalin was extracted from the skin of Chinese giant salamander or black sable with good clinical effect against tumor. This study aims to explore the mechanism of Cinobufotalin components and predict the target of action of Cinobufotalin on glioma. Methods: The active components of Cinobufotalin were screened by the Chinese medicine pharmacology database and analysis platform (TCMSP), PubChem database, etc. The potential molecular components and targets were identified and enrichment analysis was conducted through the construction of related networks and analysis of their characteristics. Relevant targets of glioma were searched through TTD, DRUGBANK, and other databases, and the intersection was found and the key targets were found too. Results: A total of 21 active components and 184 target genes of Cinobufotalin were found. According to the enrichment analysis results, the pharmacological mechanism of Cinobufotalin mainly includes inhibition of the cell cycle, promotion of cell apoptosis, and regulation of immunity. On this basis, RAC1, FOS, and NOS3 can be preliminarily predicted as potential targets of Cinobufotalin in the treatment of glioma. Conclusions: The screening of active ingredients and target prediction based on network pharmacology can provide a new research idea for the multi-target treatment of glioma with Cinobufotalin.
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| 4. |
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| 5. |
- Sun, Zhenxing, et al.
(författare)
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Fluorescein-guided surgery for spinal gliomas : Analysis of 220 consecutive cases
- 2020
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Ingår i: NOVEL THERAPEUTIC ADVANCES IN GLIOBLASTOMA. - LONDON ENGLAND : Elsevier. - 9780128211144 ; , s. 139-154
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Bokkapitel (refereegranskat)abstract
- Objective: Sodium fluorescein (FL) is widely used as a fluorescent tracer for brain tumor resection. However, FL-guided resection of spinal gliomas has been reported only occasionally. To evaluate the safety, characteristics, and usefulness of FL-guided surgery in the resection of spinal glioma. Methods: Between January 2015 and December 2018, 220 consecutive patients with 227 spinal gliomas underwent FL-guided resection using the Zeiss Pentero 900 surgical microscope with an integrated YELLOW 560 filter. FL evaluation and clinical outcomes were analyzed. Results: No FL-related complications occurred in this series. Entire tumor fluorescence was observed in 161 (70.93%) gliomas, nodular fluorescence in 46 (20.26%) tumors, and no fluorescence in 20 (8.81%) tumors. The intraoperative fluorescence of 217 (95.59%) gliomas was highly correlated with preoperative contrast-enhancing magnetic resonance imaging, except in eight ependymomas, one pilocytic astrocytoma, and one diffuse midline glioma. Gross-total resection was achieved in 78.85% (179/227) of spinal gliomas, including 94.30% (149/158) ependymal tumors and 43.48% (30/69) astrocytic and oligodendroglial tumors. At the final clinical follow-up, the spinal function of 75 (33.04%) patients showed significant improvement, 105 (46.26%) showed stabilization, and 47 (20.70%) showed deterioration. Conclusion: FL is a safe and useful real-time tool that could enhance tumor borders or residual tumors and hence increase the gross-total resection rate in cases with contrast-enhanced tumors.
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